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• W2129587007 startingPage "2858S" @default.
• W2129587007 abstract "Ornithine α-ketoglutarate (OKG) is a salt formed of 2 molecules of ornithine and 1 α-ketoglutarate. Its administration improves nutritional status in chronically malnourished (e.g., elderly) and acutely malnourished patients (especially burn and trauma patients). There is evidence that OKG activity is not the simple addition of the effects of ornithine (Orn) and α-ketoglutarate (αKG), because the presence of both moieties is required to induce the generation of key metabolites such as glutamine, proline, and arginine (Arg), whereas this does not occur when one or the other is given separately. This observation is related to the fact that the main feature of Orn at the whole-body level is to be metabolized through the Orn aminotransferase-dependent pathway, whereas the simultaneous administration of Orn and αKG saturates this pathway, diverting Orn toward metabolism into Arg. For years, OKG activity has been associated with its ability to induce the secretion of anabolic hormones, such as insulin and growth hormone, and to increase glutamine and polyamine synthesis. Recent studies using chemical inhibitors of nitric oxide synthase (NOS) suggest that nitric oxide derived from Arg could be partly involved in OKG activity. The use of genetically modified animals (i.e., knockout for NOS expression) is required to confirm this hypothesis." @default.
• W2129587007 created "2016-06-24" @default.
• W2129587007 creator A5029875699 @default.
• W2129587007 date "2004-10-01" @default.
• W2129587007 modified "2023-10-18" @default.
• W2129587007 title "Ornithine α-Ketoglutarate as a Potent Precursor of Arginine and Nitric Oxide: A New Job for an Old Friend" @default.
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• W2129587007 doi "https://doi.org/10.1093/jn/134.10.2858s" @default.
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