FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2129588731> ?p ?o ?g. }

• W2129588731 endingPage "869" @default.
• W2129588731 startingPage "859" @default.
• W2129588731 abstract "In bacterial chromosomes, the position of a gene relative to the single origin of replication generally reflects its replication timing, how often it is expressed, and consequently, its rate of evolution. However, because some archaeal genomes contain multiple origins of replication, bias in gene dosage caused by delayed replication should be minimized and hence the substitution rate of genes should associate less with chromosome position. To test this hypothesis, six archaeal genomes from the genus Sulfolobus containing three origins of replication were selected, conserved orthologs were identified, and the evolutionary rates (dN and dS) of these orthologs were quantified. Ortholog families were grouped by their consensus position and designated by their proximity to one of the three origins (O1, O2, O3). Conserved orthologs were concentrated near the origins and most variation in genome content occurred distant from the origins. Linear regressions of both synonymous and nonsynonymous substitution rates on distance from replication origins were significantly positive, the rates being greatest in the region furthest from any of the origins and slowest among genes near the origins. Genes near O1 also evolved faster than those near O2 and O3, which suggest that this origin may fire later in the cell cycle. Increased evolutionary rates and gene dispensability are strongly associated with reduced gene expression caused in part by reduced gene dosage during the cell cycle. Therefore, in this genus of Archaea as well as in many Bacteria, evolutionary rates and variation in genome content associate with replication timing." @default.
• W2129588731 created "2016-06-24" @default.
• W2129588731 creator A5005586133 @default.
• W2129588731 creator A5011908818 @default.
• W2129588731 creator A5059848332 @default.
• W2129588731 creator A5086405994 @default.
• W2129588731 date "2010-01-01" @default.
• W2129588731 modified "2023-10-14" @default.
• W2129588731 title "Evolutionary Rates and Gene Dispensability Associate with Replication Timing in the Archaeon Sulfolobus islandicus" @default.
• W2129588731 cites W123172567 @default.
• W2129588731 cites W1510523291 @default.
• W2129588731 cites W1966978997 @default.
• W2129588731 cites W1967656821 @default.
• W2129588731 cites W1980602152 @default.
• W2129588731 cites W1984542261 @default.
• W2129588731 cites W1985598198 @default.
• W2129588731 cites W1988035696 @default.
• W2129588731 cites W1988822278 @default.
• W2129588731 cites W1989563297 @default.
• W2129588731 cites W1989743311 @default.
• W2129588731 cites W1993713389 @default.
• W2129588731 cites W1994277771 @default.
• W2129588731 cites W1994946291 @default.
• W2129588731 cites W1998269721 @default.
• W2129588731 cites W2006077118 @default.
• W2129588731 cites W2009463705 @default.
• W2129588731 cites W2016430241 @default.
• W2129588731 cites W2017500947 @default.
• W2129588731 cites W2017968890 @default.
• W2129588731 cites W2027138957 @default.
• W2129588731 cites W2031542779 @default.
• W2129588731 cites W2031954637 @default.
• W2129588731 cites W2039790548 @default.
• W2129588731 cites W2042013229 @default.
• W2129588731 cites W2046082575 @default.
• W2129588731 cites W2051406384 @default.
• W2129588731 cites W2056690276 @default.
• W2129588731 cites W2062550534 @default.
• W2129588731 cites W2081746271 @default.
• W2129588731 cites W2086484371 @default.
• W2129588731 cites W2087909839 @default.
• W2129588731 cites W2091192919 @default.
• W2129588731 cites W2100002703 @default.
• W2129588731 cites W2100228967 @default.
• W2129588731 cites W2108462810 @default.
• W2129588731 cites W2110335151 @default.
• W2129588731 cites W2113938590 @default.
• W2129588731 cites W2114806178 @default.
• W2129588731 cites W2121206587 @default.
• W2129588731 cites W2127791130 @default.
• W2129588731 cites W2137015675 @default.
• W2129588731 cites W2147163870 @default.
• W2129588731 cites W2149633455 @default.
• W2129588731 cites W2155734003 @default.
• W2129588731 cites W2157358322 @default.
• W2129588731 cites W2167126318 @default.
• W2129588731 doi "https://doi.org/10.1093/gbe/evq068" @default.
• W2129588731 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3000693" @default.
• W2129588731 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20978102" @default.
• W2129588731 hasPublicationYear "2010" @default.
• W2129588731 type Work @default.
• W2129588731 sameAs 2129588731 @default.
• W2129588731 citedByCount "31" @default.
• W2129588731 countsByYear W21295887312012 @default.
• W2129588731 countsByYear W21295887312013 @default.
• W2129588731 countsByYear W21295887312014 @default.
• W2129588731 countsByYear W21295887312015 @default.
• W2129588731 countsByYear W21295887312016 @default.
• W2129588731 countsByYear W21295887312017 @default.
• W2129588731 countsByYear W21295887312018 @default.
• W2129588731 countsByYear W21295887312019 @default.
• W2129588731 countsByYear W21295887312020 @default.
• W2129588731 countsByYear W21295887312021 @default.
• W2129588731 countsByYear W21295887312022 @default.
• W2129588731 crossrefType "journal-article" @default.
• W2129588731 hasAuthorship W2129588731A5005586133 @default.
• W2129588731 hasAuthorship W2129588731A5011908818 @default.
• W2129588731 hasAuthorship W2129588731A5059848332 @default.
• W2129588731 hasAuthorship W2129588731A5086405994 @default.
• W2129588731 hasBestOaLocation W21295887311 @default.
• W2129588731 hasConcept C104317684 @default.
• W2129588731 hasConcept C141231307 @default.
• W2129588731 hasConcept C149904235 @default.
• W2129588731 hasConcept C174600577 @default.
• W2129588731 hasConcept C2777949028 @default.
• W2129588731 hasConcept C2778512757 @default.
• W2129588731 hasConcept C2778644216 @default.
• W2129588731 hasConcept C30481170 @default.
• W2129588731 hasConcept C54355233 @default.
• W2129588731 hasConcept C550995028 @default.
• W2129588731 hasConcept C58337764 @default.
• W2129588731 hasConcept C78458016 @default.
• W2129588731 hasConcept C86803240 @default.
• W2129588731 hasConcept C90132467 @default.
• W2129588731 hasConceptScore W2129588731C104317684 @default.
• W2129588731 hasConceptScore W2129588731C141231307 @default.
• W2129588731 hasConceptScore W2129588731C149904235 @default.
• W2129588731 hasConceptScore W2129588731C174600577 @default.

• next