FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2129593751> ?p ?o ?g. }

• W2129593751 endingPage "2414" @default.
• W2129593751 startingPage "2414" @default.
• W2129593751 abstract "Thrombolytic therapy may be beneficial in the treatment of some patients with pulmonary embolism. To date, no analysis has had adequate statistical power to determine whether thrombolytic therapy is associated with improved survival, compared with conventional anticoagulation.To determine mortality benefits and bleeding risks associated with thrombolytic therapy compared with anticoagulation in acute pulmonary embolism, including the subset of hemodynamically stable patients with right ventricular dysfunction (intermediate-risk pulmonary embolism).PubMed, the Cochrane Library, EMBASE, EBSCO, Web of Science, and CINAHL databases from inception through April 10, 2014.Eligible studies were randomized clinical trials comparing thrombolytic therapy vs anticoagulant therapy in pulmonary embolism patients. Sixteen trials comprising 2115 individuals were identified. Eight trials comprising 1775 patients specified inclusion of patients with intermediate-risk pulmonary embolism.Two reviewers independently extracted trial-level data including number of patients, patient characteristics, duration of follow-up, and outcomes.The primary outcomes were all-cause mortality and major bleeding. Secondary outcomes were risk of recurrent embolism and intracranial hemorrhage (ICH). Peto odds ratio (OR) estimates and associated 95% CIs were calculated using a fixed-effects model.Use of thrombolytics was associated with lower all-cause mortality (OR, 0.53; 95% CI, 0.32-0.88; 2.17% [23/1061] vs 3.89% [41/1054] with anticoagulants; number needed to treat [NNT] = 59) and greater risks of major bleeding (OR, 2.73; 95% CI, 1.91-3.91; 9.24% [98/1061] vs 3.42% [36/1054]; number needed to harm [NNH] = 18) and ICH (OR, 4.63; 95% CI, 1.78-12.04; 1.46% [15/1024] vs 0.19% [2/1019]; NNH = 78). Major bleeding was not significantly increased in patients 65 years and younger (OR, 1.25; 95% CI, 0.50-3.14). Thrombolysis was associated with a lower risk of recurrent pulmonary embolism (OR, 0.40; 95% CI, 0.22-0.74; 1.17% [12/1024] vs 3.04% [31/1019]; NNT = 54). In intermediate-risk pulmonary embolism trials, thrombolysis was associated with lower mortality (OR, 0.48; 95% CI, 0.25-0.92) and more major bleeding events (OR, 3.19; 95% CI, 2.07-4.92).Among patients with pulmonary embolism, including those who were hemodynamically stable with right ventricular dysfunction, thrombolytic therapy was associated with lower rates of all-cause mortality and increased risks of major bleeding and ICH. However, findings may not apply to patients with pulmonary embolism who are hemodynamically stable without right ventricular dysfunction." @default.
• W2129593751 created "2016-06-24" @default.
• W2129593751 creator A5000203028 @default.
• W2129593751 creator A5002582638 @default.
• W2129593751 creator A5014968374 @default.
• W2129593751 creator A5018370604 @default.
• W2129593751 creator A5022327267 @default.
• W2129593751 creator A5047001360 @default.
• W2129593751 creator A5065985671 @default.
• W2129593751 creator A5067717447 @default.
• W2129593751 creator A5081190137 @default.
• W2129593751 creator A5084192381 @default.
• W2129593751 date "2014-06-18" @default.
• W2129593751 modified "2023-10-15" @default.
• W2129593751 title "Thrombolysis for Pulmonary Embolism and Risk of All-Cause Mortality, Major Bleeding, and Intracranial Hemorrhage" @default.
• W2129593751 cites W106352447 @default.
• W2129593751 cites W1924089711 @default.
• W2129593751 cites W1964644585 @default.
• W2129593751 cites W1966953116 @default.
• W2129593751 cites W1971441597 @default.
• W2129593751 cites W1978243757 @default.
• W2129593751 cites W1993443958 @default.
• W2129593751 cites W2001027084 @default.
• W2129593751 cites W2009344499 @default.
• W2129593751 cites W2011351675 @default.
• W2129593751 cites W2011503394 @default.
• W2129593751 cites W2011611174 @default.
• W2129593751 cites W2012932483 @default.
• W2129593751 cites W2024687690 @default.
• W2129593751 cites W2026971812 @default.
• W2129593751 cites W2032284721 @default.
• W2129593751 cites W2036684303 @default.
• W2129593751 cites W2041176958 @default.
• W2129593751 cites W2043477426 @default.
• W2129593751 cites W2049852456 @default.
• W2129593751 cites W2055469806 @default.
• W2129593751 cites W2078414845 @default.
• W2129593751 cites W2081071955 @default.
• W2129593751 cites W2085984247 @default.
• W2129593751 cites W2090782984 @default.
• W2129593751 cites W2100024898 @default.
• W2129593751 cites W2100487920 @default.
• W2129593751 cites W2100964332 @default.
• W2129593751 cites W2104634108 @default.
• W2129593751 cites W2105077761 @default.
• W2129593751 cites W2107941853 @default.
• W2129593751 cites W2125435699 @default.
• W2129593751 cites W2130199362 @default.
• W2129593751 cites W2131099415 @default.
• W2129593751 cites W2140819416 @default.
• W2129593751 cites W2159007980 @default.
• W2129593751 cites W2164268628 @default.
• W2129593751 cites W2165618335 @default.
• W2129593751 cites W2314342429 @default.
• W2129593751 cites W3022903699 @default.
• W2129593751 cites W3140717836 @default.
• W2129593751 doi "https://doi.org/10.1001/jama.2014.5990" @default.
• W2129593751 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24938564" @default.
• W2129593751 hasPublicationYear "2014" @default.
• W2129593751 type Work @default.
• W2129593751 sameAs 2129593751 @default.
• W2129593751 citedByCount "577" @default.
• W2129593751 countsByYear W21295937512014 @default.
• W2129593751 countsByYear W21295937512015 @default.
• W2129593751 countsByYear W21295937512016 @default.
• W2129593751 countsByYear W21295937512017 @default.
• W2129593751 countsByYear W21295937512018 @default.
• W2129593751 countsByYear W21295937512019 @default.
• W2129593751 countsByYear W21295937512020 @default.
• W2129593751 countsByYear W21295937512021 @default.
• W2129593751 countsByYear W21295937512022 @default.
• W2129593751 countsByYear W21295937512023 @default.
• W2129593751 crossrefType "journal-article" @default.
• W2129593751 hasAuthorship W2129593751A5000203028 @default.
• W2129593751 hasAuthorship W2129593751A5002582638 @default.
• W2129593751 hasAuthorship W2129593751A5014968374 @default.
• W2129593751 hasAuthorship W2129593751A5018370604 @default.
• W2129593751 hasAuthorship W2129593751A5022327267 @default.
• W2129593751 hasAuthorship W2129593751A5047001360 @default.
• W2129593751 hasAuthorship W2129593751A5065985671 @default.
• W2129593751 hasAuthorship W2129593751A5067717447 @default.
• W2129593751 hasAuthorship W2129593751A5081190137 @default.
• W2129593751 hasAuthorship W2129593751A5084192381 @default.
• W2129593751 hasBestOaLocation W21295937511 @default.
• W2129593751 hasConcept C126322002 @default.
• W2129593751 hasConcept C141071460 @default.
• W2129593751 hasConcept C142454548 @default.
• W2129593751 hasConcept C156957248 @default.
• W2129593751 hasConcept C168563851 @default.
• W2129593751 hasConcept C2776265017 @default.
• W2129593751 hasConcept C2776478404 @default.
• W2129593751 hasConcept C2779581417 @default.
• W2129593751 hasConcept C44249647 @default.
• W2129593751 hasConcept C500558357 @default.
• W2129593751 hasConcept C67774102 @default.
• W2129593751 hasConcept C71924100 @default.
• W2129593751 hasConcept C82789193 @default.
• W2129593751 hasConceptScore W2129593751C126322002 @default.

• next