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• W2129607648 abstract "Response to systemic antifungal therapy alone remains disproportionately less satisfactory in immunosuppressed transplant and oncology patients. As insight in fungal immunopathogenesis forges ahead, interventions for boosting immune functions along with antimicrobial drugs has shown promise in preclinical experiments. The clinical experience with immunotherapy for invasive mold disease is limited. Most studies have involved small numbers of patients at a single institution or data collected retrospectively. An overview of various facts of immune modulatory drug intervention is presented, including major considerations in antifungal immunotherapy in immunosuppressed patients. Patients in whom immunotherapy is being considered must be critically evaluated to identify the underlying immune defects, including treatment-induced immunosuppression. Antifungal immunotherapy is appealing; however, before routine clinical use is recommended, well-designed prospective comparative clinical trials are urgently needed." @default.
• W2129607648 created "2016-06-24" @default.
• W2129607648 creator A5022843347 @default.
• W2129607648 date "2013-03-26" @default.
• W2129607648 modified "2023-10-04" @default.
• W2129607648 title "Immunotherapy for Invasive Mold Disease in Severely Immunosuppressed Patients" @default.
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• W2129607648 doi "https://doi.org/10.1093/cid/cit187" @default.
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