FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2129609416> ?p ?o ?g. }

• W2129609416 endingPage "455" @default.
• W2129609416 startingPage "448" @default.
• W2129609416 abstract "Secretion of 27-hydroxycholesterol (27OHC) from macrophages is considered as an alternative to HDL-mediated reverse transport of excess cholesterol. We investigated 27OHC-concentrations in plasma of humans and mice with monogenic disorders of HDL metabolism. As compared to family controls mutations in the genes for apolipoprotein A-I, ATP binding cassette transporter (ABC) A1 and lecithin:cholesterol acylstransferase (LCAT) were associated with reduced concentrations of both HDL-cholesterol and HDL-27OHC whereas mutations in the genes for cholesterylester transfer protein (CETP), scavenger receptor type BI and hepatic lipase were associated with elevated HDL concentrations of either sterol. Compared to family controls and relative to the concentrations of total 27OHC and cholesterol, lower 27OHC-ester but normal cholesterylester levels were found in HDL of heterozygous LCAT mutation carriers and nonHDL of heterozygous CETP mutation carriers. In family controls, LCAT activity and CETP mass were more strongly correlated with 27OHC-ester than cholesterylester concentrations in HDL and nonHDL, respectively. These findings suggest that the formation and transfer of 27OHC-esters are more sensitive to reduced activities of LCAT and CETP, respectively, than the formation and transfer of cholesterylesters. 27OHC plasma levels were also decreased in apoA-I-, ABCA1- or LCAT-knockout mice but increased in SR-BI-knockout mice. Transplantation of ABCA1- and/or ABCG1-deficient bone marrow into LDL receptor deficient mice decreased plasma levels of 27OHC. In conclusion, mutations or absence of HDL genes lead to distinct alterations in the quantity, esterification or lipoprotein distribution of 27OHC. These findings argue against the earlier suggestion that 27OHC-metabolism in plasma occurs independently of HDL." @default.
• W2129609416 created "2016-06-24" @default.
• W2129609416 creator A5013598309 @default.
• W2129609416 creator A5022615366 @default.
• W2129609416 creator A5023192558 @default.
• W2129609416 creator A5024733637 @default.
• W2129609416 creator A5027046285 @default.
• W2129609416 creator A5039652605 @default.
• W2129609416 creator A5048849311 @default.
• W2129609416 creator A5062618621 @default.
• W2129609416 creator A5073506012 @default.
• W2129609416 creator A5081108450 @default.
• W2129609416 creator A5083750961 @default.
• W2129609416 date "2011-02-01" @default.
• W2129609416 modified "2023-10-16" @default.
• W2129609416 title "Plasma levels of 27-hydroxycholesterol in humans and mice with monogenic disturbances of high density lipoprotein metabolism" @default.
• W2129609416 cites W1860487341 @default.
• W2129609416 cites W1861462909 @default.
• W2129609416 cites W1964082209 @default.
• W2129609416 cites W1979624565 @default.
• W2129609416 cites W1983435041 @default.
• W2129609416 cites W1990501023 @default.
• W2129609416 cites W1991835243 @default.
• W2129609416 cites W1998129355 @default.
• W2129609416 cites W2022320294 @default.
• W2129609416 cites W2024529248 @default.
• W2129609416 cites W2026393575 @default.
• W2129609416 cites W2028960395 @default.
• W2129609416 cites W2029841039 @default.
• W2129609416 cites W2036972869 @default.
• W2129609416 cites W2046821878 @default.
• W2129609416 cites W2048958063 @default.
• W2129609416 cites W2079080809 @default.
• W2129609416 cites W2103681867 @default.
• W2129609416 cites W2110895977 @default.
• W2129609416 cites W2111733232 @default.
• W2129609416 cites W2111920850 @default.
• W2129609416 cites W2115220026 @default.
• W2129609416 cites W2115914704 @default.
• W2129609416 cites W2115935785 @default.
• W2129609416 cites W2123630829 @default.
• W2129609416 cites W2125411529 @default.
• W2129609416 cites W2157277441 @default.
• W2129609416 cites W2167634890 @default.
• W2129609416 cites W2186878728 @default.
• W2129609416 cites W4232009782 @default.
• W2129609416 doi "https://doi.org/10.1016/j.atherosclerosis.2010.10.042" @default.
• W2129609416 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21130455" @default.
• W2129609416 hasPublicationYear "2011" @default.
• W2129609416 type Work @default.
• W2129609416 sameAs 2129609416 @default.
• W2129609416 citedByCount "54" @default.
• W2129609416 countsByYear W21296094162013 @default.
• W2129609416 countsByYear W21296094162014 @default.
• W2129609416 countsByYear W21296094162015 @default.
• W2129609416 countsByYear W21296094162016 @default.
• W2129609416 countsByYear W21296094162017 @default.
• W2129609416 countsByYear W21296094162018 @default.
• W2129609416 countsByYear W21296094162019 @default.
• W2129609416 countsByYear W21296094162020 @default.
• W2129609416 countsByYear W21296094162021 @default.
• W2129609416 countsByYear W21296094162022 @default.
• W2129609416 countsByYear W21296094162023 @default.
• W2129609416 crossrefType "journal-article" @default.
• W2129609416 hasAuthorship W2129609416A5013598309 @default.
• W2129609416 hasAuthorship W2129609416A5022615366 @default.
• W2129609416 hasAuthorship W2129609416A5023192558 @default.
• W2129609416 hasAuthorship W2129609416A5024733637 @default.
• W2129609416 hasAuthorship W2129609416A5027046285 @default.
• W2129609416 hasAuthorship W2129609416A5039652605 @default.
• W2129609416 hasAuthorship W2129609416A5048849311 @default.
• W2129609416 hasAuthorship W2129609416A5062618621 @default.
• W2129609416 hasAuthorship W2129609416A5073506012 @default.
• W2129609416 hasAuthorship W2129609416A5081108450 @default.
• W2129609416 hasAuthorship W2129609416A5083750961 @default.
• W2129609416 hasBestOaLocation W21296094161 @default.
• W2129609416 hasConcept C104317684 @default.
• W2129609416 hasConcept C110459506 @default.
• W2129609416 hasConcept C126322002 @default.
• W2129609416 hasConcept C134018914 @default.
• W2129609416 hasConcept C149011108 @default.
• W2129609416 hasConcept C185592680 @default.
• W2129609416 hasConcept C2776330080 @default.
• W2129609416 hasConcept C2777704780 @default.
• W2129609416 hasConcept C2778163477 @default.
• W2129609416 hasConcept C2779134260 @default.
• W2129609416 hasConcept C2779564620 @default.
• W2129609416 hasConcept C2780072125 @default.
• W2129609416 hasConcept C2780541478 @default.
• W2129609416 hasConcept C41443022 @default.
• W2129609416 hasConcept C45505151 @default.
• W2129609416 hasConcept C55493867 @default.
• W2129609416 hasConcept C57089818 @default.
• W2129609416 hasConcept C62231903 @default.
• W2129609416 hasConcept C62746215 @default.
• W2129609416 hasConcept C71924100 @default.
• W2129609416 hasConcept C86803240 @default.
• W2129609416 hasConceptScore W2129609416C104317684 @default.

• next