Matches in SemOpenAlex for { <https://semopenalex.org/work/W2129647444> ?p ?o ?g. }
- W2129647444 endingPage "480" @default.
- W2129647444 startingPage "471" @default.
- W2129647444 abstract "Abstract Acetylation of C-terminal lysine residues in the p53 tumor suppressor is associated with increased stability and transcription factor activity. The function, protein level, and acetylation of p53 are downregulated by mdm2, which in its turn is inhibited by the p14ARF tumor suppressor. Here, we show that p14ARF increases the level of p53 acetylated at lysine 382 in a nuclear chromatin-rich fraction. Unexpectedly, this accumulation of p53AcK382 is dramatically enhanced in the presence of ectopic mdm2. In light of these observations, we propose that p14ARF increases the binding of p53–mdm2 complexes to chromatin, thereby limiting the access of protein deacetylases to p53. Supporting this notion, we show that p53AcK382 can be deacetylated in the cytoplasm and that sirtuin SirT2 catalyzes this reaction. These results help understand why inhibition of both SirT1 and SirT2 is needed to achieve effective activation of p53 by small-molecule sirtuin inhibitors. Mol Cancer Ther; 12(4); 471–80. ©2013 AACR." @default.
- W2129647444 created "2016-06-24" @default.
- W2129647444 creator A5023781365 @default.
- W2129647444 creator A5031751539 @default.
- W2129647444 creator A5038531653 @default.
- W2129647444 creator A5042113951 @default.
- W2129647444 creator A5052715161 @default.
- W2129647444 creator A5077376192 @default.
- W2129647444 creator A5078127727 @default.
- W2129647444 date "2013-04-01" @default.
- W2129647444 modified "2023-10-16" @default.
- W2129647444 title "Modulation of p53 C-Terminal Acetylation by mdm2, p14ARF, and Cytoplasmic SirT2" @default.
- W2129647444 cites W1485459479 @default.
- W2129647444 cites W1560780012 @default.
- W2129647444 cites W1571200845 @default.
- W2129647444 cites W1606024367 @default.
- W2129647444 cites W1947531295 @default.
- W2129647444 cites W1971565911 @default.
- W2129647444 cites W1975004085 @default.
- W2129647444 cites W1978827662 @default.
- W2129647444 cites W1981706109 @default.
- W2129647444 cites W1983660125 @default.
- W2129647444 cites W1989168159 @default.
- W2129647444 cites W1998943082 @default.
- W2129647444 cites W2000501612 @default.
- W2129647444 cites W2004706142 @default.
- W2129647444 cites W2007249806 @default.
- W2129647444 cites W2014749419 @default.
- W2129647444 cites W2022329480 @default.
- W2129647444 cites W2022888698 @default.
- W2129647444 cites W2025722611 @default.
- W2129647444 cites W2028608234 @default.
- W2129647444 cites W2029343580 @default.
- W2129647444 cites W2041959419 @default.
- W2129647444 cites W2049763628 @default.
- W2129647444 cites W2050259175 @default.
- W2129647444 cites W2050745715 @default.
- W2129647444 cites W2051303456 @default.
- W2129647444 cites W2051821952 @default.
- W2129647444 cites W2065646551 @default.
- W2129647444 cites W2068753140 @default.
- W2129647444 cites W2076053308 @default.
- W2129647444 cites W2078361436 @default.
- W2129647444 cites W2091041925 @default.
- W2129647444 cites W2093141524 @default.
- W2129647444 cites W2093775600 @default.
- W2129647444 cites W2095424116 @default.
- W2129647444 cites W2096882254 @default.
- W2129647444 cites W2097933346 @default.
- W2129647444 cites W2099907467 @default.
- W2129647444 cites W2103237568 @default.
- W2129647444 cites W2104787082 @default.
- W2129647444 cites W2110048031 @default.
- W2129647444 cites W2110118637 @default.
- W2129647444 cites W2114803943 @default.
- W2129647444 cites W2120956575 @default.
- W2129647444 cites W2134354168 @default.
- W2129647444 cites W2137893910 @default.
- W2129647444 cites W2140513990 @default.
- W2129647444 cites W2154986076 @default.
- W2129647444 cites W2165179185 @default.
- W2129647444 cites W2166213130 @default.
- W2129647444 cites W2170819844 @default.
- W2129647444 doi "https://doi.org/10.1158/1535-7163.mct-12-0904" @default.
- W2129647444 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23416275" @default.
- W2129647444 hasPublicationYear "2013" @default.
- W2129647444 type Work @default.
- W2129647444 sameAs 2129647444 @default.
- W2129647444 citedByCount "35" @default.
- W2129647444 countsByYear W21296474442014 @default.
- W2129647444 countsByYear W21296474442015 @default.
- W2129647444 countsByYear W21296474442016 @default.
- W2129647444 countsByYear W21296474442017 @default.
- W2129647444 countsByYear W21296474442018 @default.
- W2129647444 countsByYear W21296474442019 @default.
- W2129647444 countsByYear W21296474442020 @default.
- W2129647444 countsByYear W21296474442021 @default.
- W2129647444 countsByYear W21296474442023 @default.
- W2129647444 crossrefType "journal-article" @default.
- W2129647444 hasAuthorship W2129647444A5023781365 @default.
- W2129647444 hasAuthorship W2129647444A5031751539 @default.
- W2129647444 hasAuthorship W2129647444A5038531653 @default.
- W2129647444 hasAuthorship W2129647444A5042113951 @default.
- W2129647444 hasAuthorship W2129647444A5052715161 @default.
- W2129647444 hasAuthorship W2129647444A5077376192 @default.
- W2129647444 hasAuthorship W2129647444A5078127727 @default.
- W2129647444 hasBestOaLocation W21296474441 @default.
- W2129647444 hasConcept C104317684 @default.
- W2129647444 hasConcept C119157956 @default.
- W2129647444 hasConcept C127561419 @default.
- W2129647444 hasConcept C185592680 @default.
- W2129647444 hasConcept C199848840 @default.
- W2129647444 hasConcept C2776016237 @default.
- W2129647444 hasConcept C2776192174 @default.
- W2129647444 hasConcept C2776536020 @default.
- W2129647444 hasConcept C2776750431 @default.
- W2129647444 hasConcept C2778264664 @default.
- W2129647444 hasConcept C2780561631 @default.