Matches in SemOpenAlex for { <https://semopenalex.org/work/W2129647927> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2129647927 abstract "The number of cardiac beta-adrenergic receptors and the activity of isoproterenol-stimulated adenylate cyclase are lower in spontaneously hypertensive rats (SHRs) and may account for diminished inotropic responsiveness to beta-agonists. Differences in isoproterenol-induced desensitization of the cardiac adenylate cyclase system between 14- to 16-week-old SHRs and Wistar-Kyoto (WKY) controls were studied using cardiac membranes, isolated cardiac myocytes, and intact animals. In both animal strains, the isoproterenol-induced loss of beta-adrenergic receptors in the cardiac membranes required adenosine triphosphate (ATP), magnesium (Mg2+), and guanosine 5'-triphosphate (GTP). The ATP and Mg2+ requirement may reflect a crucial role for a phosphorylation step, since desensitization was prevented by cordycepin, a nonspecific phosphorylation inhibitor. In both isolated myocytes and intact animals, isoproterenol induced a redistribution of the beta-adrenergic receptors (but not of adenylate cyclase) from the cell membrane to the cytosol. Internalization of the receptors was not secondary to the loss of membrane fragments to the cytosol, since the receptors sequestered in a fraction devoid of cell surface markers. In all three preparations, the extent of isoproterenol-induced loss of beta-receptors and isoproterenol-stimulated adenylate cyclase was considerably lower in SHRs than WKYs. This difference appeared to be due to a reduced capacity of isoproterenol to induce translocation of beta-receptors from the membranes to the cytosol of SHRs, because of a change in the physical properties of either the beta-receptors themselves or the membranes into which they were embedded." @default.
- W2129647927 created "2016-06-24" @default.
- W2129647927 creator A5062909601 @default.
- W2129647927 creator A5000015443 @default.
- W2129647927 date "1984-03-01" @default.
- W2129647927 modified "2023-10-18" @default.
- W2129647927 title "Decreased isoproterenol-induced down-regulation of beta-adrenergic receptors in the myocardium of SHR." @default.
- W2129647927 doi "https://doi.org/10.1161/01.hyp.6.2_pt_2.i31" @default.
- W2129647927 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6327523" @default.
- W2129647927 hasPublicationYear "1984" @default.
- W2129647927 type Work @default.
- W2129647927 sameAs 2129647927 @default.
- W2129647927 citedByCount "17" @default.
- W2129647927 crossrefType "journal-article" @default.
- W2129647927 hasAuthorship W2129647927A5000015443 @default.
- W2129647927 hasAuthorship W2129647927A5062909601 @default.
- W2129647927 hasConcept C118716 @default.
- W2129647927 hasConcept C126322002 @default.
- W2129647927 hasConcept C134018914 @default.
- W2129647927 hasConcept C135285700 @default.
- W2129647927 hasConcept C170493617 @default.
- W2129647927 hasConcept C180526460 @default.
- W2129647927 hasConcept C181199279 @default.
- W2129647927 hasConcept C185592680 @default.
- W2129647927 hasConcept C24998067 @default.
- W2129647927 hasConcept C2776090920 @default.
- W2129647927 hasConcept C2777995097 @default.
- W2129647927 hasConcept C2780069284 @default.
- W2129647927 hasConcept C40465926 @default.
- W2129647927 hasConcept C55493867 @default.
- W2129647927 hasConcept C71924100 @default.
- W2129647927 hasConcept C78976303 @default.
- W2129647927 hasConcept C86803240 @default.
- W2129647927 hasConcept C98539663 @default.
- W2129647927 hasConceptScore W2129647927C118716 @default.
- W2129647927 hasConceptScore W2129647927C126322002 @default.
- W2129647927 hasConceptScore W2129647927C134018914 @default.
- W2129647927 hasConceptScore W2129647927C135285700 @default.
- W2129647927 hasConceptScore W2129647927C170493617 @default.
- W2129647927 hasConceptScore W2129647927C180526460 @default.
- W2129647927 hasConceptScore W2129647927C181199279 @default.
- W2129647927 hasConceptScore W2129647927C185592680 @default.
- W2129647927 hasConceptScore W2129647927C24998067 @default.
- W2129647927 hasConceptScore W2129647927C2776090920 @default.
- W2129647927 hasConceptScore W2129647927C2777995097 @default.
- W2129647927 hasConceptScore W2129647927C2780069284 @default.
- W2129647927 hasConceptScore W2129647927C40465926 @default.
- W2129647927 hasConceptScore W2129647927C55493867 @default.
- W2129647927 hasConceptScore W2129647927C71924100 @default.
- W2129647927 hasConceptScore W2129647927C78976303 @default.
- W2129647927 hasConceptScore W2129647927C86803240 @default.
- W2129647927 hasConceptScore W2129647927C98539663 @default.
- W2129647927 hasIssue "2_pt_2" @default.
- W2129647927 hasLocation W21296479271 @default.
- W2129647927 hasLocation W21296479272 @default.
- W2129647927 hasOpenAccess W2129647927 @default.
- W2129647927 hasPrimaryLocation W21296479271 @default.
- W2129647927 hasRelatedWork W143387945 @default.
- W2129647927 hasRelatedWork W1993508801 @default.
- W2129647927 hasRelatedWork W2029329258 @default.
- W2129647927 hasRelatedWork W2042164169 @default.
- W2129647927 hasRelatedWork W2129647927 @default.
- W2129647927 hasRelatedWork W2166602181 @default.
- W2129647927 hasRelatedWork W2169909436 @default.
- W2129647927 hasRelatedWork W2170858177 @default.
- W2129647927 hasRelatedWork W2271157540 @default.
- W2129647927 hasRelatedWork W2416266855 @default.
- W2129647927 hasVolume "6" @default.
- W2129647927 isParatext "false" @default.
- W2129647927 isRetracted "false" @default.
- W2129647927 magId "2129647927" @default.
- W2129647927 workType "article" @default.