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• W2129664159 abstract "Objective: Transluminal resection of the aortic valve was already successfully carried out by our group. The aim of this study was the analysis of the gross anatomy and the histology of the surrounding tissue after resection. Methods: Aortic valve resection was performed in postmortem human hearts (endoluminal (EL) n = 9, transapical (TA) n = 4). After deployment of the aortic valve isolation chamber, the leaflets were resected with a Thullium:YAG laser scalpel (cw, 20 W). After resection, the hearts were analyzed to check for lesions caused by resectioning the associated tools. Therefore, gross anatomy and histological analysis were performed (H&E staining). Results: Lesions of the aortic annulus were seen in 3/9 (EL) (depth: 583 ± 186 μm) and 2/4 (TA) (120 μm and one complete perforation), lesions of the aorta (ascending-arch-descending) in 4-9-0/9 (EL) and 0-0-0/4 (TA), lesions of the mitral valve in 0/9 (EL) and 0/4 (TA), lesions of the papillary muscle in 0/9 (EL) and 2/4 (TA) (depth: 400 μm and 450 μm), lesions of the endomyocardium in 0/9 (EL) and 4/4 (TA) (depth: 258 ± 102 μm). The coronary ostia remained unaffected. Conclusions: This study shows fewer severe lesions in the aorta after transapical antegrade access compared to the transluminal retrograde approach. Especially noteworthy is that the aortic arch remains unaffected by the transapical procedure. These data demonstrate the transapical approach as less hazardous." @default.
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• W2129664159 date "2009-07-01" @default.
• W2129664159 modified "2023-10-14" @default.
• W2129664159 title "Percutaneous aortic valve replacement: gross anatomy and histological findings after transapical and endoluminal resection of human aortic valves in situ☆☆☆" @default.
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• W2129664159 doi "https://doi.org/10.1016/j.ejcts.2009.03.031" @default.
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