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- W2129671174 abstract "Isoelectric focusing on ultra-thin polyacryl amide gels was employed to study alterations in the distribution patterns of soluble β and γ-crystallins during the development of cataract in the Emory (EM) mouse. These alterations were compared with corresponding changes occurring in clear control lenses of the same age from the cataract-resistant (CR) strain.At two months of age both strains gave similar patterns. At four and fourteen months the EM lens showed depressed β peaks compared to the CR lens. At fourteen months the EM lens had reduced γ2 and γ5 compared with the CR lens. At twenty-four months the EM lens had all γ's markedly reduced, especially γ5, with the complete disappearance of γ4 which was however still present in the CR lens at twenty-six months. At twenty-four months the EM lens had a relatively large amount of β5 but no β5a or β5b; the latter two were present in the CR Tens surrounding β5 which was less prominent than in the EM lens. The decrease in γ's in the twenty-four months EM lens was approximately equalled by an apparent increase in β's. Of the above changes only the decrease in β's at four months can be considered precataractous and perhaps a primary change in cataractogenesis. The later changes in both β and γ may be secondary although they are certainly at least associated with cataractogenesis. The invariable decrease in γ with age is noticeably accelerated in cataractogenesis." @default.
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- W2129671174 date "1984-01-01" @default.
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- W2129671174 title "The Emory mouse cataract: Changes in the β and γ-crystallins during aging and cataractogenesis as revealed by isoelectric focusing of the native soluble proteins" @default.
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- W2129671174 doi "https://doi.org/10.3109/02713688409000831" @default.
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