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- W2129675250 abstract "Abstract Cytotoxic T lymphocytes (CTLs) specific for an HLA-A2–presented peptide epitope of the Wilms tumor antigen-1 (WT1) can selectively kill immature human leukemia progenitor and stem cells in vitro. In this study we have used retroviral gene transfer to introduce a WT1-specific T-cell receptor (TCR) into T lymphocytes obtained from patients with leukemia and from healthy donors. TCR-transduced T cells kill leukemia cells in vitro and display WT1-specific cytokine production. Intravenous injection of TCR-transduced T cells into nonobese diabetic–severe combined immunodeficiency (NOD/SCID) mice harboring human leukemia cells resulted in leukemia elimination, whereas transfer of control T cells transduced with an irrelevant TCR was ineffective. The data suggest that adoptive immunotherapy with WT1-TCR gene–modified patient T cells should be considered for the treatment of leukemia." @default.
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- W2129675250 date "2005-11-01" @default.
- W2129675250 modified "2023-10-18" @default.
- W2129675250 title "Elimination of human leukemia cells in NOD/SCID mice by WT1-TCR gene–transduced human T cells" @default.
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- W2129675250 doi "https://doi.org/10.1182/blood-2005-01-0146" @default.
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