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• W2129688081 abstract "Aging and degeneration of human intervertebral disc (IVD) are associated with biochemical changes, including racemization and glycation. These changes can only be counteracted by protein turnover. Little is known about the longevity of IVD elastin in health or disease. Yet, such knowledge is important for a quantitative understanding of tissue synthesis and degradation. We have measured the accumulation of d-Asp and pentosidine in IVD elastin. Samples representing a broad range of ages (28–82 years) and degeneration grades (1–5) were analyzed. d/l-Asp for elastin increased linearly with age from 3.2% (early 30s) to 14.8% (early 80s) for normal tissue (grades 1–2) and from 1.7% (late 20s) to 6.0% (until the mid 50s) for degenerate tissue (grades 3–5) with accumulation rates of 16.2 ± 3.1 × 10− 4 and 11.7 ± 3.8 × 10− 4 year− 1, respectively; no significant difference was found between these values (p < 0.05). Above the mid 50s, a decrease in d-Asp accumulation was recorded in the degenerate tissue. d-Asp accumulation correlated well with pentosidine content for elastin from healthy and degenerate tissues combined. We conclude that IVD elastin is metabolically‐stable and long‐lived in both healthy and degenerate human IVDs, with signs of new synthesis in the latter. The correlation of d‐Asp with pentosidine content suggests that both these agents may be used as markers in the overall aging process of IVD. Accumulation of modified IVD elastin argues for its longevity and may have a negative impact on its role in disc function. Weak signs of newly synthesized molecules may act to counteract this effect in degenerate tissue." @default.
• W2129688081 created "2016-06-24" @default.
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• W2129688081 date "2012-10-01" @default.
• W2129688081 modified "2023-10-14" @default.
• W2129688081 title "Longevity of elastin in human intervertebral disc as probed by the racemization of aspartic acid" @default.
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• W2129688081 cites W1557253076 @default.
• W2129688081 cites W1841004874 @default.
• W2129688081 cites W1898812238 @default.
• W2129688081 cites W1944789189 @default.
• W2129688081 cites W1966188170 @default.
• W2129688081 cites W1966527137 @default.
• W2129688081 cites W1967699392 @default.
• W2129688081 cites W1971474467 @default.
• W2129688081 cites W1975437978 @default.
• W2129688081 cites W1977597990 @default.
• W2129688081 cites W1983672742 @default.
• W2129688081 cites W1985268990 @default.
• W2129688081 cites W1986207703 @default.
• W2129688081 cites W1986416713 @default.
• W2129688081 cites W1989383397 @default.
• W2129688081 cites W1994344250 @default.
• W2129688081 cites W2000349942 @default.
• W2129688081 cites W2003134048 @default.
• W2129688081 cites W2006613142 @default.
• W2129688081 cites W2007413067 @default.
• W2129688081 cites W2008348227 @default.
• W2129688081 cites W2010766679 @default.
• W2129688081 cites W2011269182 @default.
• W2129688081 cites W2014768906 @default.
• W2129688081 cites W2015127183 @default.
• W2129688081 cites W2016497865 @default.
• W2129688081 cites W2017528738 @default.
• W2129688081 cites W2020418396 @default.
• W2129688081 cites W2023311117 @default.
• W2129688081 cites W2024942482 @default.
• W2129688081 cites W2030025221 @default.
• W2129688081 cites W2030453203 @default.
• W2129688081 cites W2032971072 @default.
• W2129688081 cites W2033369217 @default.
• W2129688081 cites W2034335685 @default.
• W2129688081 cites W2035789174 @default.
• W2129688081 cites W2042871183 @default.
• W2129688081 cites W2048443971 @default.
• W2129688081 cites W2048659410 @default.
• W2129688081 cites W2048877651 @default.
• W2129688081 cites W2049081530 @default.
• W2129688081 cites W2049954179 @default.
• W2129688081 cites W2051613001 @default.
• W2129688081 cites W2054221638 @default.
• W2129688081 cites W2060448151 @default.
• W2129688081 cites W2061269546 @default.
• W2129688081 cites W2065502996 @default.
• W2129688081 cites W2067805144 @default.
• W2129688081 cites W2069136488 @default.
• W2129688081 cites W2069648064 @default.
• W2129688081 cites W2071668615 @default.
• W2129688081 cites W2073813597 @default.
• W2129688081 cites W2076211550 @default.
• W2129688081 cites W2079935767 @default.
• W2129688081 cites W2080602313 @default.
• W2129688081 cites W2080803003 @default.
• W2129688081 cites W2089315626 @default.
• W2129688081 cites W2097483735 @default.
• W2129688081 cites W2104248063 @default.
• W2129688081 cites W2108689038 @default.
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• W2129688081 cites W2128431867 @default.
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• W2129688081 cites W4211019851 @default.
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• W2129688081 doi "https://doi.org/10.1016/j.bbagen.2012.06.010" @default.
• W2129688081 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22728886" @default.
• W2129688081 hasPublicationYear "2012" @default.
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