FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2129696543> ?p ?o ?g. }

• W2129696543 endingPage "1338" @default.
• W2129696543 startingPage "1330" @default.
• W2129696543 abstract "Telomerase is an RNA-protein complex responsible for extending one strand of the telomere terminal repeats. Analysis of the telomerase complex in budding yeasts has revealed the presence of one catalytic protein subunit (Est2p/TERT) and at least two noncatalytic components (Est1p and Est3p). The TERT subunit is essential for telomerase catalysis, while the functions of Est1p and Est3p have not been precisely elucidated. In an earlier study, we showed that telomerase derived from a Candida est1-null mutant is defective in primer utilization in vitro; it exhibits reduced initiation and processivity on primers that terminate in two regions of the telomere repeat. Here we show that telomerase derived from a Candida est3-null mutant has nearly identical defects in primer utilization and processivity. Further analysis revealed an unexpected mutual dependence of Est1p and Est3p in their assembly into the full telomerase complex, which accounts for the similarity between the mutant enzymes. We also developed an affinity isolation and an in vitro reconstitution protocol for the telomerase complex that will facilitate future mechanistic studies." @default.
• W2129696543 created "2016-06-24" @default.
• W2129696543 creator A5022617866 @default.
• W2129696543 creator A5052295581 @default.
• W2129696543 creator A5053361953 @default.
• W2129696543 creator A5065552028 @default.
• W2129696543 date "2007-08-01" @default.
• W2129696543 modified "2023-09-26" @default.
• W2129696543 title "Mutual Dependence of <i>Candida albicans</i> Est1p and Est3p in Telomerase Assembly and Activation" @default.
• W2129696543 cites W1575542444 @default.
• W2129696543 cites W1943069336 @default.
• W2129696543 cites W1965213816 @default.
• W2129696543 cites W1965303630 @default.
• W2129696543 cites W1983823417 @default.
• W2129696543 cites W1985623818 @default.
• W2129696543 cites W1995287099 @default.
• W2129696543 cites W1997141870 @default.
• W2129696543 cites W2031936092 @default.
• W2129696543 cites W2032149581 @default.
• W2129696543 cites W2039574035 @default.
• W2129696543 cites W2040204581 @default.
• W2129696543 cites W2045571168 @default.
• W2129696543 cites W2052786131 @default.
• W2129696543 cites W2057356532 @default.
• W2129696543 cites W2080045652 @default.
• W2129696543 cites W2083968461 @default.
• W2129696543 cites W2099590298 @default.
• W2129696543 cites W2111458920 @default.
• W2129696543 cites W2112393026 @default.
• W2129696543 cites W2119507799 @default.
• W2129696543 cites W2129920504 @default.
• W2129696543 cites W2130283365 @default.
• W2129696543 cites W2130525093 @default.
• W2129696543 cites W2138101634 @default.
• W2129696543 cites W2144417959 @default.
• W2129696543 cites W2145554588 @default.
• W2129696543 cites W2165003754 @default.
• W2129696543 cites W2165580070 @default.
• W2129696543 cites W4295934140 @default.
• W2129696543 doi "https://doi.org/10.1128/ec.00069-07" @default.
• W2129696543 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1951134" @default.
• W2129696543 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17545315" @default.
• W2129696543 hasPublicationYear "2007" @default.
• W2129696543 type Work @default.
• W2129696543 sameAs 2129696543 @default.
• W2129696543 citedByCount "39" @default.
• W2129696543 countsByYear W21296965432012 @default.
• W2129696543 countsByYear W21296965432013 @default.
• W2129696543 countsByYear W21296965432015 @default.
• W2129696543 countsByYear W21296965432017 @default.
• W2129696543 countsByYear W21296965432020 @default.
• W2129696543 countsByYear W21296965432021 @default.
• W2129696543 countsByYear W21296965432022 @default.
• W2129696543 countsByYear W21296965432023 @default.
• W2129696543 crossrefType "journal-article" @default.
• W2129696543 hasAuthorship W2129696543A5022617866 @default.
• W2129696543 hasAuthorship W2129696543A5052295581 @default.
• W2129696543 hasAuthorship W2129696543A5053361953 @default.
• W2129696543 hasAuthorship W2129696543A5065552028 @default.
• W2129696543 hasBestOaLocation W21296965431 @default.
• W2129696543 hasConcept C104292427 @default.
• W2129696543 hasConcept C104317684 @default.
• W2129696543 hasConcept C125593758 @default.
• W2129696543 hasConcept C131140672 @default.
• W2129696543 hasConcept C143065580 @default.
• W2129696543 hasConcept C153911025 @default.
• W2129696543 hasConcept C177336024 @default.
• W2129696543 hasConcept C178790620 @default.
• W2129696543 hasConcept C185592680 @default.
• W2129696543 hasConcept C2777563447 @default.
• W2129696543 hasConcept C2780917455 @default.
• W2129696543 hasConcept C34558173 @default.
• W2129696543 hasConcept C54355233 @default.
• W2129696543 hasConcept C552990157 @default.
• W2129696543 hasConcept C67705224 @default.
• W2129696543 hasConcept C82381507 @default.
• W2129696543 hasConcept C86803240 @default.
• W2129696543 hasConcept C94581717 @default.
• W2129696543 hasConcept C95444343 @default.
• W2129696543 hasConceptScore W2129696543C104292427 @default.
• W2129696543 hasConceptScore W2129696543C104317684 @default.
• W2129696543 hasConceptScore W2129696543C125593758 @default.
• W2129696543 hasConceptScore W2129696543C131140672 @default.
• W2129696543 hasConceptScore W2129696543C143065580 @default.
• W2129696543 hasConceptScore W2129696543C153911025 @default.
• W2129696543 hasConceptScore W2129696543C177336024 @default.
• W2129696543 hasConceptScore W2129696543C178790620 @default.
• W2129696543 hasConceptScore W2129696543C185592680 @default.
• W2129696543 hasConceptScore W2129696543C2777563447 @default.
• W2129696543 hasConceptScore W2129696543C2780917455 @default.
• W2129696543 hasConceptScore W2129696543C34558173 @default.
• W2129696543 hasConceptScore W2129696543C54355233 @default.
• W2129696543 hasConceptScore W2129696543C552990157 @default.
• W2129696543 hasConceptScore W2129696543C67705224 @default.
• W2129696543 hasConceptScore W2129696543C82381507 @default.
• W2129696543 hasConceptScore W2129696543C86803240 @default.
• W2129696543 hasConceptScore W2129696543C94581717 @default.
• W2129696543 hasConceptScore W2129696543C95444343 @default.

• next