FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2129699904> ?p ?o ?g. }

• W2129699904 endingPage "355" @default.
• W2129699904 startingPage "348" @default.
• W2129699904 abstract "The G protein-coupled formylpeptide receptor (FPR), known to mediate phagocytic leucocyte chemotaxis in reponse to bacterial- and host-derived agonists, was expressed by tumor cells in specimens of surgically removed more highly malignant human gliomas. In human glioblastoma cell lines, FPR activation increased cell motility, tumorigenicity and production of angiogenic factors. In studies of the mechanistic basis for the selective expression of FPR in more highly malignant gliomas, we found that the DNA methyltransferase inhibitor 5-Aza-2′-deoxycytidine (Aza), while promoting the differentiation of human glioblastoma cells, downregulated FPR expression. Aza also reduced the global methylation levels in glioblastoma cells and activated the pathway of p53 tumor suppressor. Methylation-specific polymerase chain reaction revealed that Aza treatment of tumor cells reduced the methylation of p53 promoter, which was accompanied by increased expression of p53 gene and protein. In addition, overexpression of p53 in glioblastoma cells mimicked the effect of Aza treatment as shown by increased cell differentiation but reduction in FPR expression, the capacity of tumor sphere formation in soft agar and tumorigenesis in nude mice. Furthermore, Aza treatment or overexpression of the wild-type p53 in glioblastoma cells increased the binding of p53 to FPR promoter region shown by chromatin immunoprecipitation. These results indicate that increased methylation of p53 gene retains human glioblastoma cells at a more poorly differentiated phase associated with the aberrant expression of FPR as a tumor-promoting cell surface receptor." @default.
• W2129699904 created "2016-06-24" @default.
• W2129699904 creator A5000716419 @default.
• W2129699904 creator A5011981086 @default.
• W2129699904 creator A5015235892 @default.
• W2129699904 creator A5033074884 @default.
• W2129699904 creator A5039403729 @default.
• W2129699904 creator A5040885646 @default.
• W2129699904 creator A5052056212 @default.
• W2129699904 creator A5075003658 @default.
• W2129699904 creator A5076535039 @default.
• W2129699904 date "2008-11-26" @default.
• W2129699904 modified "2023-09-27" @default.
• W2129699904 title "Regulation of the leucocyte chemoattractant receptor FPR in glioblastoma cells by cell differentiation" @default.
• W2129699904 cites W1484293540 @default.
• W2129699904 cites W1497854809 @default.
• W2129699904 cites W1519411905 @default.
• W2129699904 cites W1538285087 @default.
• W2129699904 cites W1580870868 @default.
• W2129699904 cites W1588811519 @default.
• W2129699904 cites W1656339735 @default.
• W2129699904 cites W1966474816 @default.
• W2129699904 cites W1974713792 @default.
• W2129699904 cites W1997576503 @default.
• W2129699904 cites W2001286841 @default.
• W2129699904 cites W2003772519 @default.
• W2129699904 cites W2003982318 @default.
• W2129699904 cites W2009187090 @default.
• W2129699904 cites W2010732143 @default.
• W2129699904 cites W2012024423 @default.
• W2129699904 cites W2014775748 @default.
• W2129699904 cites W2029026381 @default.
• W2129699904 cites W2036193202 @default.
• W2129699904 cites W2053119119 @default.
• W2129699904 cites W2053146787 @default.
• W2129699904 cites W2054799738 @default.
• W2129699904 cites W2055722183 @default.
• W2129699904 cites W2059311738 @default.
• W2129699904 cites W2079168625 @default.
• W2129699904 cites W2080310122 @default.
• W2129699904 cites W2088539970 @default.
• W2129699904 cites W2097361537 @default.
• W2129699904 cites W2108966286 @default.
• W2129699904 cites W2125663263 @default.
• W2129699904 cites W2126679630 @default.
• W2129699904 cites W2134542375 @default.
• W2129699904 cites W2146939134 @default.
• W2129699904 cites W2153529101 @default.
• W2129699904 cites W2154621334 @default.
• W2129699904 cites W2156134411 @default.
• W2129699904 cites W2164280001 @default.
• W2129699904 cites W2169229217 @default.
• W2129699904 cites W2180595540 @default.
• W2129699904 cites W226104906 @default.
• W2129699904 cites W2315386492 @default.
• W2129699904 cites W2322343992 @default.
• W2129699904 cites W92445173 @default.
• W2129699904 doi "https://doi.org/10.1093/carcin/bgn266" @default.
• W2129699904 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2639049" @default.
• W2129699904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19037090" @default.
• W2129699904 hasPublicationYear "2008" @default.
• W2129699904 type Work @default.
• W2129699904 sameAs 2129699904 @default.
• W2129699904 citedByCount "21" @default.
• W2129699904 countsByYear W21296999042012 @default.
• W2129699904 countsByYear W21296999042013 @default.
• W2129699904 countsByYear W21296999042014 @default.
• W2129699904 countsByYear W21296999042015 @default.
• W2129699904 countsByYear W21296999042016 @default.
• W2129699904 countsByYear W21296999042017 @default.
• W2129699904 countsByYear W21296999042019 @default.
• W2129699904 countsByYear W21296999042020 @default.
• W2129699904 countsByYear W21296999042021 @default.
• W2129699904 countsByYear W21296999042022 @default.
• W2129699904 crossrefType "journal-article" @default.
• W2129699904 hasAuthorship W2129699904A5000716419 @default.
• W2129699904 hasAuthorship W2129699904A5011981086 @default.
• W2129699904 hasAuthorship W2129699904A5015235892 @default.
• W2129699904 hasAuthorship W2129699904A5033074884 @default.
• W2129699904 hasAuthorship W2129699904A5039403729 @default.
• W2129699904 hasAuthorship W2129699904A5040885646 @default.
• W2129699904 hasAuthorship W2129699904A5052056212 @default.
• W2129699904 hasAuthorship W2129699904A5075003658 @default.
• W2129699904 hasAuthorship W2129699904A5076535039 @default.
• W2129699904 hasBestOaLocation W21296999041 @default.
• W2129699904 hasConcept C101762097 @default.
• W2129699904 hasConcept C104317684 @default.
• W2129699904 hasConcept C134320426 @default.
• W2129699904 hasConcept C148738053 @default.
• W2129699904 hasConcept C1491633281 @default.
• W2129699904 hasConcept C150194340 @default.
• W2129699904 hasConcept C153911025 @default.
• W2129699904 hasConcept C170493617 @default.
• W2129699904 hasConcept C190727270 @default.
• W2129699904 hasConcept C2778227246 @default.
• W2129699904 hasConcept C33288867 @default.
• W2129699904 hasConcept C502942594 @default.
• W2129699904 hasConcept C54166955 @default.

• next