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• W2129701484 abstract "Back-propagating action potentials (bAPs) are involved in associative synaptic plasticity and the modulation of dendritic excitability. We have used high-speed confocal and two-photon imaging to measure calcium and voltage signals associated with action potential propagation into oblique branches of CA1 pyramidal neurons in adult hippocampal slices. The spatial profile of the bAP-associated Ca2+ influx was biphasic, with an initial increase in the proximity of the branch point followed by a progressive decrease. Voltage imaging in the branches showed that bAP amplitude was initially constant and then steadily declined with distance from the soma. To determine the role of transient K+ channels in this profile, we used external Ba2+ (150 μm) as a channel blocker, after characterizing its effect on A-type K+ channels in the apical trunk. Bath application of Ba2+ significantly reduced the A-type K+ current in outside-out patches and nearly eliminated the distance-dependent decrease in bAP amplitude and its associated Ca2+ signal. Finally, small amplitude bAPs at more distal oblique branch locations could be boosted by simultaneous branch depolarization, such that the paired Ca2+ signal became nearly the same for proximal and distal oblique dendrites. These data suggest that dendritic K+ channels regulate the amplitude of bAPs to create a dendritic Ca2+ signal whose magnitude is inversely related to the electrotonic distance from the soma when bAPs are not associated with a significant amount of localized synaptic input. This distance-dependent Ca2+ signal from bAPs, however, can be amplified and a strong associative signal is produced once the proper correlation between synaptic activation and AP output is achieved. We hypothesize that these two signals may be involved in the regulation of the expression and activity of dendritic voltage- and ligand-gated ion channels." @default.
• W2129701484 created "2016-06-24" @default.
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• W2129701484 date "2007-04-16" @default.
• W2129701484 modified "2023-09-27" @default.
• W2129701484 title "Associative pairing enhances action potential back-propagation in radial oblique branches of CA1 pyramidal neurons" @default.
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• W2129701484 doi "https://doi.org/10.1113/jphysiol.2006.121343" @default.
• W2129701484 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2075451" @default.
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