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- W2129712840 endingPage "95" @default.
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- W2129712840 abstract "Abstract Past autism research has often been dedicated to tracing the causes of the disorder to a localized neurological abnormality, a single functional network, or a single cognitive‐behavioral domain. In this review, I argue that autism is a “distributed disorder” on various levels of study (genetic, neuroanatomical, neurofunctional, behavioral). “Localizing” models are therefore not promising. The large array of potential genetic risk factors suggests that multiple (or all) emerging functional brain networks are affected during early development. This is supported by widespread growth abnormalities throughout the brain. Interactions during development between affected functional networks and atypical experiential effects (associated with atypical behavior) in children with autism further complicate the neurological bases of the disorder, resulting in an “exponentially distributed” profile. Promising approaches to a better characterization of neural endophenotypes in autism are provided by techniques investigating white matter and connectivity, such as MR spectroscopy, diffusion‐tensor imaging (DTI), and functional connectivity MRI. According to a recent hypothesis, the autistic brain is generally characterized by “underconnectivity.” However, not all findings are consistent with this view. The concepts and methodology of functional connectivity need to be refined and results need to be corroborated by anatomical studies (such as DTI tractography) before definitive conclusions can be drawn. © 2007 Wiley‐Liss, Inc. MRDD Research Reviews 2007;13:85–95." @default.
- W2129712840 created "2016-06-24" @default.
- W2129712840 creator A5000269904 @default.
- W2129712840 date "2007-01-01" @default.
- W2129712840 modified "2023-10-07" @default.
- W2129712840 title "The study of autism as a distributed disorder" @default.
- W2129712840 cites W1540505936 @default.
- W2129712840 cites W1579305661 @default.
- W2129712840 cites W17694978 @default.
- W2129712840 cites W1821241690 @default.
- W2129712840 cites W1886029756 @default.
- W2129712840 cites W1968557007 @default.
- W2129712840 cites W1973759448 @default.
- W2129712840 cites W1973875834 @default.
- W2129712840 cites W1974400004 @default.
- W2129712840 cites W1976933908 @default.
- W2129712840 cites W1977082044 @default.
- W2129712840 cites W1987662636 @default.
- W2129712840 cites W1988370154 @default.
- W2129712840 cites W1988473644 @default.
- W2129712840 cites W1993621007 @default.
- W2129712840 cites W1995454866 @default.
- W2129712840 cites W1996634693 @default.
- W2129712840 cites W1996849853 @default.
- W2129712840 cites W1996859891 @default.
- W2129712840 cites W1999061147 @default.
- W2129712840 cites W1999077602 @default.
- W2129712840 cites W1999843868 @default.
- W2129712840 cites W2000454722 @default.
- W2129712840 cites W2000619876 @default.
- W2129712840 cites W2005149292 @default.
- W2129712840 cites W2007787462 @default.
- W2129712840 cites W2009011497 @default.
- W2129712840 cites W2009494091 @default.
- W2129712840 cites W2018786179 @default.
- W2129712840 cites W2021241248 @default.
- W2129712840 cites W2023965963 @default.
- W2129712840 cites W2025319978 @default.
- W2129712840 cites W2025512612 @default.
- W2129712840 cites W2025550217 @default.
- W2129712840 cites W2025551837 @default.
- W2129712840 cites W2026452816 @default.
- W2129712840 cites W2034853194 @default.
- W2129712840 cites W2035541936 @default.
- W2129712840 cites W2040739567 @default.
- W2129712840 cites W2042526117 @default.
- W2129712840 cites W2043038397 @default.
- W2129712840 cites W2044349722 @default.
- W2129712840 cites W2044709288 @default.
- W2129712840 cites W2046345553 @default.
- W2129712840 cites W2053829454 @default.
- W2129712840 cites W2054610619 @default.
- W2129712840 cites W2054612084 @default.
- W2129712840 cites W2059564226 @default.
- W2129712840 cites W2061231162 @default.
- W2129712840 cites W2064364338 @default.
- W2129712840 cites W2064755515 @default.
- W2129712840 cites W2066042950 @default.
- W2129712840 cites W2070039055 @default.
- W2129712840 cites W2070083499 @default.
- W2129712840 cites W2074457840 @default.
- W2129712840 cites W2075402838 @default.
- W2129712840 cites W2076600981 @default.
- W2129712840 cites W2080859877 @default.
- W2129712840 cites W2081014794 @default.
- W2129712840 cites W2083302393 @default.
- W2129712840 cites W2087838692 @default.
- W2129712840 cites W2092120221 @default.
- W2129712840 cites W2096704400 @default.
- W2129712840 cites W2097072002 @default.
- W2129712840 cites W2097833812 @default.
- W2129712840 cites W2100022067 @default.
- W2129712840 cites W2103078809 @default.
- W2129712840 cites W2105251885 @default.
- W2129712840 cites W2108019777 @default.
- W2129712840 cites W2111813237 @default.
- W2129712840 cites W2114116770 @default.
- W2129712840 cites W2114418526 @default.
- W2129712840 cites W2116974110 @default.
- W2129712840 cites W2118201036 @default.
- W2129712840 cites W2120574495 @default.
- W2129712840 cites W2125446880 @default.
- W2129712840 cites W2126866445 @default.
- W2129712840 cites W2127810520 @default.
- W2129712840 cites W2128359078 @default.
- W2129712840 cites W2128592952 @default.
- W2129712840 cites W2130113542 @default.
- W2129712840 cites W2130166597 @default.
- W2129712840 cites W2131007620 @default.
- W2129712840 cites W2134175099 @default.
- W2129712840 cites W2139399313 @default.
- W2129712840 cites W2141805926 @default.
- W2129712840 cites W2143865775 @default.
- W2129712840 cites W2144696231 @default.
- W2129712840 cites W2146437136 @default.
- W2129712840 cites W2147785803 @default.
- W2129712840 cites W2148620450 @default.
- W2129712840 cites W2150873111 @default.