FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2129724870> ?p ?o ?g. }

• W2129724870 endingPage "483" @default.
• W2129724870 startingPage "476" @default.
• W2129724870 abstract "Fermentation of dietary fiber within the colonic lumen yields short chain fatty acids (SCFA) such as butyrate, which may modulate colonic mucosal biology and inhibit the development of a malignant phenotype. However, different fibers yield varying proportions of various SCFA. We studied the effects of the three most common SCFA, acetate, butyrate, and propionate, on the proliferation, adhesion, and motility of the human intestinal Caco-2 cell line, as well as the effects of these SCFA on alkaline phosphatase and dipeptidyl dipeptidase specific activity (common laboratory markers of differentiation). In addition, we examined the modulation of c-myc protein and the tyrosine phosphorylation of cellular proteins by these SCFA in order to determine whether the variations in the potency of these three SCFA for phenotypic change extended to variations in effects on intracellular signaling and protooncogene expression. All three SCFA tended to slow proliferation, promote brush border enzyme activity, and inhibit both adhesion to and motility across a type I collagen matrix substrate. However, we observed substantial differences in the potency of these three SCFA with regard to these effects. In particular, butyrate was uniformly more potent than an equimolar concentration of acetate whereas equimolar propionate achieved comparable effects with regard to proliferation and brush border enzyme activity but was intermediate between butyrate and acetate with regard to modulation of cell-matrix interactions. Similarly, the SCFA downregulated c-myc protein levels and modulated the phosphorylation of several intracellular tyrosine phosphoproteins, but the effects of the three SCFA varied substantially for these parameters. These results suggest that the common short chain fatty acids are not equipotent in their effects on human Caco-2 colon cancer cell biology. Such differences in potency could contribute to the observed differences in effects of different dietary fibers in vivo." @default.
• W2129724870 created "2016-06-24" @default.
• W2129724870 creator A5013951018 @default.
• W2129724870 creator A5019529285 @default.
• W2129724870 creator A5032399192 @default.
• W2129724870 date "1998-04-01" @default.
• W2129724870 modified "2023-10-18" @default.
• W2129724870 title "Differential Modulation of Human (Caco-2) Colon Cancer Cell Line Phenotype by Short Chain Fatty Acids" @default.
• W2129724870 cites W1536544150 @default.
• W2129724870 cites W156558474 @default.
• W2129724870 cites W1586750917 @default.
• W2129724870 cites W1826133046 @default.
• W2129724870 cites W1865863549 @default.
• W2129724870 cites W1911488345 @default.
• W2129724870 cites W1928067122 @default.
• W2129724870 cites W1974651994 @default.
• W2129724870 cites W197645179 @default.
• W2129724870 cites W1984889921 @default.
• W2129724870 cites W1985952392 @default.
• W2129724870 cites W1988786053 @default.
• W2129724870 cites W1991283020 @default.
• W2129724870 cites W1992002324 @default.
• W2129724870 cites W1995133050 @default.
• W2129724870 cites W2007194872 @default.
• W2129724870 cites W2009440060 @default.
• W2129724870 cites W2011885649 @default.
• W2129724870 cites W2025029890 @default.
• W2129724870 cites W2025536728 @default.
• W2129724870 cites W2029750671 @default.
• W2129724870 cites W2030565228 @default.
• W2129724870 cites W2036103104 @default.
• W2129724870 cites W2044306909 @default.
• W2129724870 cites W2058669904 @default.
• W2129724870 cites W2070998214 @default.
• W2129724870 cites W2071395559 @default.
• W2129724870 cites W2072069101 @default.
• W2129724870 cites W2077101501 @default.
• W2129724870 cites W2082285399 @default.
• W2129724870 cites W2088890372 @default.
• W2129724870 cites W2096990907 @default.
• W2129724870 cites W2130089260 @default.
• W2129724870 cites W2144009842 @default.
• W2129724870 cites W2155714796 @default.
• W2129724870 cites W2163431702 @default.
• W2129724870 cites W2167097542 @default.
• W2129724870 cites W2167223199 @default.
• W2129724870 cites W2229800306 @default.
• W2129724870 cites W2267133899 @default.
• W2129724870 cites W2409816850 @default.
• W2129724870 cites W2466025021 @default.
• W2129724870 cites W272177094 @default.
• W2129724870 cites W332112146 @default.
• W2129724870 cites W597047104 @default.
• W2129724870 doi "https://doi.org/10.3181/00379727-217-44261" @default.
• W2129724870 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9521097" @default.
• W2129724870 hasPublicationYear "1998" @default.
• W2129724870 type Work @default.
• W2129724870 sameAs 2129724870 @default.
• W2129724870 citedByCount "39" @default.
• W2129724870 countsByYear W21297248702012 @default.
• W2129724870 countsByYear W21297248702013 @default.
• W2129724870 countsByYear W21297248702014 @default.
• W2129724870 countsByYear W21297248702015 @default.
• W2129724870 countsByYear W21297248702016 @default.
• W2129724870 countsByYear W21297248702017 @default.
• W2129724870 countsByYear W21297248702018 @default.
• W2129724870 countsByYear W21297248702019 @default.
• W2129724870 countsByYear W21297248702021 @default.
• W2129724870 countsByYear W21297248702022 @default.
• W2129724870 crossrefType "journal-article" @default.
• W2129724870 hasAuthorship W2129724870A5013951018 @default.
• W2129724870 hasAuthorship W2129724870A5019529285 @default.
• W2129724870 hasAuthorship W2129724870A5032399192 @default.
• W2129724870 hasConcept C100544194 @default.
• W2129724870 hasConcept C11960822 @default.
• W2129724870 hasConcept C130316041 @default.
• W2129724870 hasConcept C1491633281 @default.
• W2129724870 hasConcept C185592680 @default.
• W2129724870 hasConcept C193176779 @default.
• W2129724870 hasConcept C2776165026 @default.
• W2129724870 hasConcept C2776979534 @default.
• W2129724870 hasConcept C2777553839 @default.
• W2129724870 hasConcept C2780014933 @default.
• W2129724870 hasConcept C41625074 @default.
• W2129724870 hasConcept C5426402 @default.
• W2129724870 hasConcept C55493867 @default.
• W2129724870 hasConcept C58207958 @default.
• W2129724870 hasConcept C79879829 @default.
• W2129724870 hasConcept C85528070 @default.
• W2129724870 hasConcept C86803240 @default.
• W2129724870 hasConcept C95444343 @default.
• W2129724870 hasConceptScore W2129724870C100544194 @default.
• W2129724870 hasConceptScore W2129724870C11960822 @default.
• W2129724870 hasConceptScore W2129724870C130316041 @default.
• W2129724870 hasConceptScore W2129724870C1491633281 @default.
• W2129724870 hasConceptScore W2129724870C185592680 @default.
• W2129724870 hasConceptScore W2129724870C193176779 @default.
• W2129724870 hasConceptScore W2129724870C2776165026 @default.

• next