Matches in SemOpenAlex for { <https://semopenalex.org/work/W2129746518> ?p ?o ?g. }
- W2129746518 endingPage "1212" @default.
- W2129746518 startingPage "1204" @default.
- W2129746518 abstract "Background: Hispanic children have both a higher incidence and a poorer outcome in acute lymphoblastic leukemia (ALL). Moreover, a higher incidence for therapy-related acute myeloid leukemia with 11q23 translocations after treatment with topoisomerase II (topo II) inhibitors has been observed in Hispanic children with ALL. We sought to determine the potential role of genetic variants within the topoisomerase IIα gene (TOP2A), within the mixed lineage leukemia gene (MLL) and two of its translocation partners, cyclin AMP response element-binding protein gene (CREBBP) and E1A binding protein gene (EP300) in the increased sensitivity of Hispanic children with ALL to topo II inhibitors.Methods: Fifty-two tagged single nucleotide polymorphisms (SNP) covering the four genes were genotyped in 241 samples (66 children with ALL and 175 age matched controls) of self-identified Hispanic origin.Results: Two SNPs within MLL (rs525549 and rs6589664) and three SNPs within EP300 (rs5758222, rs7286979, and rs20551) were significantly associated with ALL (P = 0.001–0.04). A significant gene-dosage effect for increasing numbers of potential high-risk genotypes (OR = 16.66; P = 2 × 10−5) and a major haplotype significantly associated with ALL (OR = 5.68; P = 2 × 10−6) were found. Replication in a sample of 137 affected White children and 239 controls showed that only rs6589664 (MLL) was significantly associated in this ethnic group.Conclusions: Our findings indicate that the association between ALL and common genetic variants within MLL and EP300 is population specific.Impact: Replication of our findings in independent Hispanic populations is warranted to elucidate the role of these variants in ALL susceptibility and define their importance in the ethnic specific differences in ALL risk. Cancer Epidemiol Biomarkers Prev; 20(6); 1204–12. ©2011 AACR." @default.
- W2129746518 created "2016-06-24" @default.
- W2129746518 creator A5002213309 @default.
- W2129746518 creator A5024582072 @default.
- W2129746518 creator A5030514536 @default.
- W2129746518 creator A5048513986 @default.
- W2129746518 creator A5053203924 @default.
- W2129746518 creator A5055519116 @default.
- W2129746518 creator A5056916024 @default.
- W2129746518 creator A5064741369 @default.
- W2129746518 creator A5069039346 @default.
- W2129746518 creator A5069736362 @default.
- W2129746518 date "2011-04-14" @default.
- W2129746518 modified "2023-09-23" @default.
- W2129746518 title "Multilocus Association of Genetic Variants in MLL, CREBBP, EP300, and TOP2A with Childhood Acute Lymphoblastic Leukemia in Hispanics from Texas" @default.
- W2129746518 cites W1843960791 @default.
- W2129746518 cites W1919590537 @default.
- W2129746518 cites W1964895626 @default.
- W2129746518 cites W1969504098 @default.
- W2129746518 cites W1981069958 @default.
- W2129746518 cites W1982315838 @default.
- W2129746518 cites W1983393070 @default.
- W2129746518 cites W1989493752 @default.
- W2129746518 cites W1992020987 @default.
- W2129746518 cites W1994299156 @default.
- W2129746518 cites W1995799142 @default.
- W2129746518 cites W1997033094 @default.
- W2129746518 cites W1998823290 @default.
- W2129746518 cites W2008799566 @default.
- W2129746518 cites W2009575015 @default.
- W2129746518 cites W2012114257 @default.
- W2129746518 cites W2015323124 @default.
- W2129746518 cites W2030796899 @default.
- W2129746518 cites W2034552567 @default.
- W2129746518 cites W2040804373 @default.
- W2129746518 cites W2048960972 @default.
- W2129746518 cites W2050980503 @default.
- W2129746518 cites W2056176185 @default.
- W2129746518 cites W2077921697 @default.
- W2129746518 cites W2079764524 @default.
- W2129746518 cites W2088018702 @default.
- W2129746518 cites W2093075205 @default.
- W2129746518 cites W2096450527 @default.
- W2129746518 cites W2116967011 @default.
- W2129746518 cites W2117521409 @default.
- W2129746518 cites W2118931743 @default.
- W2129746518 cites W2120412844 @default.
- W2129746518 cites W2124285724 @default.
- W2129746518 cites W2133339791 @default.
- W2129746518 cites W2135663247 @default.
- W2129746518 cites W2140379683 @default.
- W2129746518 cites W2147704921 @default.
- W2129746518 cites W2153142568 @default.
- W2129746518 cites W2154215238 @default.
- W2129746518 cites W2166907165 @default.
- W2129746518 cites W2171360917 @default.
- W2129746518 cites W2210090508 @default.
- W2129746518 cites W2217532849 @default.
- W2129746518 cites W2242790540 @default.
- W2129746518 cites W2245871225 @default.
- W2129746518 cites W2271460576 @default.
- W2129746518 cites W2463771178 @default.
- W2129746518 cites W279116378 @default.
- W2129746518 cites W51523625 @default.
- W2129746518 doi "https://doi.org/10.1158/1055-9965.epi-11-0059" @default.
- W2129746518 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21493871" @default.
- W2129746518 hasPublicationYear "2011" @default.
- W2129746518 type Work @default.
- W2129746518 sameAs 2129746518 @default.
- W2129746518 citedByCount "13" @default.
- W2129746518 countsByYear W21297465182012 @default.
- W2129746518 countsByYear W21297465182013 @default.
- W2129746518 countsByYear W21297465182015 @default.
- W2129746518 countsByYear W21297465182016 @default.
- W2129746518 countsByYear W21297465182017 @default.
- W2129746518 countsByYear W21297465182019 @default.
- W2129746518 crossrefType "journal-article" @default.
- W2129746518 hasAuthorship W2129746518A5002213309 @default.
- W2129746518 hasAuthorship W2129746518A5024582072 @default.
- W2129746518 hasAuthorship W2129746518A5030514536 @default.
- W2129746518 hasAuthorship W2129746518A5048513986 @default.
- W2129746518 hasAuthorship W2129746518A5053203924 @default.
- W2129746518 hasAuthorship W2129746518A5055519116 @default.
- W2129746518 hasAuthorship W2129746518A5056916024 @default.
- W2129746518 hasAuthorship W2129746518A5064741369 @default.
- W2129746518 hasAuthorship W2129746518A5069039346 @default.
- W2129746518 hasAuthorship W2129746518A5069736362 @default.
- W2129746518 hasBestOaLocation W21297465181 @default.
- W2129746518 hasConcept C104317684 @default.
- W2129746518 hasConcept C135763542 @default.
- W2129746518 hasConcept C139275648 @default.
- W2129746518 hasConcept C143998085 @default.
- W2129746518 hasConcept C153209595 @default.
- W2129746518 hasConcept C180754005 @default.
- W2129746518 hasConcept C197754878 @default.
- W2129746518 hasConcept C2778729363 @default.
- W2129746518 hasConcept C502942594 @default.
- W2129746518 hasConcept C54355233 @default.