FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2129758889> ?p ?o ?g. }

• W2129758889 endingPage "e1004818" @default.
• W2129758889 startingPage "e1004818" @default.
• W2129758889 abstract "A large fraction of human genes are regulated by genetic variation near the transcribed sequence (cis-eQTL, expression quantitative trait locus), and many cis-eQTLs have implications for human disease. Less is known regarding the effects of genetic variation on expression of distant genes (trans-eQTLs) and their biological mechanisms. In this work, we use genome-wide data on SNPs and array-based expression measures from mononuclear cells obtained from a population-based cohort of 1,799 Bangladeshi individuals to characterize cis- and trans-eQTLs and determine if observed trans-eQTL associations are mediated by expression of transcripts in cis with the SNPs showing trans-association, using Sobel tests of mediation. We observed 434 independent trans-eQTL associations at a false-discovery rate of 0.05, and 189 of these trans-eQTLs were also cis-eQTLs (enrichment P<0.0001). Among these 189 trans-eQTL associations, 39 were significantly attenuated after adjusting for a cis-mediator based on Sobel P<10-5. We attempted to replicate 21 of these mediation signals in two European cohorts, and while only 7 trans-eQTL associations were present in one or both cohorts, 6 showed evidence of cis-mediation. Analyses of simulated data show that complete mediation will be observed as partial mediation in the presence of mediator measurement error or imperfect LD between measured and causal variants. Our data demonstrates that trans-associations can become significantly stronger or switch directions after adjusting for a potential mediator. Using simulated data, we demonstrate that this phenomenon is expected in the presence of strong cis-trans confounding and when the measured cis-transcript is correlated with the true (unmeasured) mediator. In conclusion, by applying mediation analysis to eQTL data, we show that a substantial fraction of observed trans-eQTL associations can be explained by cis-mediation. Future studies should focus on understanding the mechanisms underlying widespread cis-mediation and their relevance to disease biology, as well as using mediation analysis to improve eQTL discovery." @default.
• W2129758889 created "2016-06-24" @default.
• W2129758889 creator A5003374278 @default.
• W2129758889 creator A5015182161 @default.
• W2129758889 creator A5029020734 @default.
• W2129758889 creator A5032097085 @default.
• W2129758889 creator A5036373801 @default.
• W2129758889 creator A5038382717 @default.
• W2129758889 creator A5039008277 @default.
• W2129758889 creator A5049036974 @default.
• W2129758889 creator A5054577204 @default.
• W2129758889 creator A5065566745 @default.
• W2129758889 creator A5072005435 @default.
• W2129758889 creator A5075350184 @default.
• W2129758889 creator A5081425275 @default.
• W2129758889 creator A5083530167 @default.
• W2129758889 creator A5085571988 @default.
• W2129758889 creator A5088404253 @default.
• W2129758889 creator A5088912437 @default.
• W2129758889 date "2014-12-04" @default.
• W2129758889 modified "2023-10-16" @default.
• W2129758889 title "Mediation Analysis Demonstrates That Trans-eQTLs Are Often Explained by Cis-Mediation: A Genome-Wide Analysis among 1,800 South Asians" @default.
• W2129758889 cites W1977089938 @default.
• W2129758889 cites W1984939442 @default.
• W2129758889 cites W2001320379 @default.
• W2129758889 cites W2008957118 @default.
• W2129758889 cites W2015690645 @default.
• W2129758889 cites W2019983262 @default.
• W2129758889 cites W2024108088 @default.
• W2129758889 cites W2025207912 @default.
• W2129758889 cites W2035451872 @default.
• W2129758889 cites W2039708283 @default.
• W2129758889 cites W2043842514 @default.
• W2129758889 cites W2055750498 @default.
• W2129758889 cites W2069496935 @default.
• W2129758889 cites W2085459418 @default.
• W2129758889 cites W2100697281 @default.
• W2129758889 cites W2107665951 @default.
• W2129758889 cites W2112087830 @default.
• W2129758889 cites W2117007075 @default.
• W2129758889 cites W2122698311 @default.
• W2129758889 cites W2123706805 @default.
• W2129758889 cites W2127925738 @default.
• W2129758889 cites W2135199713 @default.
• W2129758889 cites W2136091734 @default.
• W2129758889 cites W2141231045 @default.
• W2129758889 cites W2144961623 @default.
• W2129758889 cites W2152816554 @default.
• W2129758889 cites W2154998360 @default.
• W2129758889 cites W2161056048 @default.
• W2129758889 cites W2166501262 @default.
• W2129758889 cites W2167016530 @default.
• W2129758889 cites W4292811746 @default.
• W2129758889 doi "https://doi.org/10.1371/journal.pgen.1004818" @default.
• W2129758889 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4256471" @default.
• W2129758889 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25474530" @default.
• W2129758889 hasPublicationYear "2014" @default.
• W2129758889 type Work @default.
• W2129758889 sameAs 2129758889 @default.
• W2129758889 citedByCount "79" @default.
• W2129758889 countsByYear W21297588892015 @default.
• W2129758889 countsByYear W21297588892016 @default.
• W2129758889 countsByYear W21297588892017 @default.
• W2129758889 countsByYear W21297588892018 @default.
• W2129758889 countsByYear W21297588892019 @default.
• W2129758889 countsByYear W21297588892020 @default.
• W2129758889 countsByYear W21297588892021 @default.
• W2129758889 countsByYear W21297588892022 @default.
• W2129758889 countsByYear W21297588892023 @default.
• W2129758889 crossrefType "journal-article" @default.
• W2129758889 hasAuthorship W2129758889A5003374278 @default.
• W2129758889 hasAuthorship W2129758889A5015182161 @default.
• W2129758889 hasAuthorship W2129758889A5029020734 @default.
• W2129758889 hasAuthorship W2129758889A5032097085 @default.
• W2129758889 hasAuthorship W2129758889A5036373801 @default.
• W2129758889 hasAuthorship W2129758889A5038382717 @default.
• W2129758889 hasAuthorship W2129758889A5039008277 @default.
• W2129758889 hasAuthorship W2129758889A5049036974 @default.
• W2129758889 hasAuthorship W2129758889A5054577204 @default.
• W2129758889 hasAuthorship W2129758889A5065566745 @default.
• W2129758889 hasAuthorship W2129758889A5072005435 @default.
• W2129758889 hasAuthorship W2129758889A5075350184 @default.
• W2129758889 hasAuthorship W2129758889A5081425275 @default.
• W2129758889 hasAuthorship W2129758889A5083530167 @default.
• W2129758889 hasAuthorship W2129758889A5085571988 @default.
• W2129758889 hasAuthorship W2129758889A5088404253 @default.
• W2129758889 hasAuthorship W2129758889A5088912437 @default.
• W2129758889 hasBestOaLocation W21297588891 @default.
• W2129758889 hasConcept C104317684 @default.
• W2129758889 hasConcept C106208931 @default.
• W2129758889 hasConcept C135763542 @default.
• W2129758889 hasConcept C153209595 @default.
• W2129758889 hasConcept C168393362 @default.
• W2129758889 hasConcept C17744445 @default.
• W2129758889 hasConcept C179420905 @default.
• W2129758889 hasConcept C186413461 @default.
• W2129758889 hasConcept C199539241 @default.
• W2129758889 hasConcept C2908647359 @default.

• next