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• W2129761208 abstract "The objectives of this study were to compare the pharmacokinetics and COX selectivity of three commercially available formulations of firocoxib in the horse. Six healthy adult horses were administered a single dose of 57 mg intravenous, oral paste or oral tablet firocoxib in a three‐way, randomized, crossover design. Blood was collected at predetermined times for PGE 2 and TXB 2 concentrations, as well as plasma drug concentrations. Similar to other reports, firocoxib exhibited a long elimination half‐life (31.07 ± 10.64 h), a large volume of distribution (1.81 ± 0.59L/kg), and a slow clearance (42.61 ± 11.28 mL/h/kg). Comparison of the oral formulations revealed a higher C max , shorter T max , and greater AUC for the paste compared to the tablet. Bioavailability was 112% and 88% for the paste and tablet, respectively. Maximum inhibition of PGE 2 was 83.76% for the I.V. formulation, 52.95% for the oral paste formulation, and 46.22% for the oral tablet formulation. Pharmacodynamic modeling suggests an IC 50 of approximately 27 ng/mL and an IC 80 of 108 ng/ mL for COX2 inhibition. Inhibition of TXB 2 production was not detected. This study indicates a lack of bioequivalence between the oral formulations of firocoxib when administered as a single dose to healthy horses." @default.
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• W2129761208 date "2014-11-05" @default.
• W2129761208 modified "2023-10-03" @default.
• W2129761208 title "Pharmacokinetics and pharmacodynamics of three formulations of firocoxib in healthy horses" @default.
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• W2129761208 doi "https://doi.org/10.1111/jvp.12177" @default.
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