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• W2129762272 abstract "Controversy continues regarding the effects of administration of digitalis upon the exercise electrocardiogram. Thus, maximal treadmill exercise tests were performed before and two weeks after administration of 0.25 mg of digoxin daily in 15 normal subjects (documented by cardiac catheterization and coronary arteriographic studies). Administration of digitalis induced abnormal findings on exercise tests in all 14 subjects with serum levels of digoxin greater than or equal to 0.5 ng/ml; however, at workloads greater than 75 to 90 percent of maximal predicted heart rate, the changes in the ST segment reverted to a normal configuration in all subjects, thereby providing differentiation of digitalis-induced ST-segment alterations from those due to myocardial ischemia at maximal treadmill stress. Controversy continues regarding the effects of administration of digitalis upon the exercise electrocardiogram. Thus, maximal treadmill exercise tests were performed before and two weeks after administration of 0.25 mg of digoxin daily in 15 normal subjects (documented by cardiac catheterization and coronary arteriographic studies). Administration of digitalis induced abnormal findings on exercise tests in all 14 subjects with serum levels of digoxin greater than or equal to 0.5 ng/ml; however, at workloads greater than 75 to 90 percent of maximal predicted heart rate, the changes in the ST segment reverted to a normal configuration in all subjects, thereby providing differentiation of digitalis-induced ST-segment alterations from those due to myocardial ischemia at maximal treadmill stress. Effects of Digitalis on the Exercise ElectrocardiogramCHESTVol. 72Issue 6PreviewTonkon and his colleagues (see page 714 ) have partially clarified the analysis of exercise testing in patients who are receiving digoxin. This was done by showing that certain depressions of the J junction, sometimes accompanied by flat or upward-sloping ST-segment depressions, are not associated with any current abnormality of the coronary arteries. The ST-segment changes in these subjects were modest. More pronounced ST-segment depressions may be a source of confusion for clinicians. Full-Text PDF" @default.
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• W2129762272 title "Effects of Digitalis on the Exercise Electrocardiogram in Normal Adult Subjects" @default.
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• W2129762272 doi "https://doi.org/10.1378/chest.72.6.714" @default.
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