FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2129778857> ?p ?o ?g. }

• W2129778857 endingPage "785" @default.
• W2129778857 startingPage "779" @default.
• W2129778857 abstract "The SmD1(83-119) peptide is a major target of the B cell response in patients with systemic lupus erythematosus (SLE).To investigate the T cell response directed against this peptide, its disease specificity, and possible impact on SLE pathogenesis.Peripheral blood mononuclear cells derived from 28 patients with SLE and 29 healthy and disease controls were stimulated by the SmD1(83-119) and the recombinant (r)SmD1 protein, and [3H]thymidine incorporation was measured. Patients with SLE were simultaneously tested for autoantibodies, disease activity, clinical symptoms, and medical treatments.T cell reactivity against the SmD1(83-119) peptide was detected in 11/28 (39%) patients with SLE and against the rSmD1 protein in 10/28 (36%) patients. In contrast, only 2/29 (7%) controls exhibited SmD1 reactivity. An analysis of proliferation kinetics showed that SmD1 reactive T cells are activated in vivo, as additionally confirmed by cytometric analysis. Addition of mammalian dsDNA to rSmD1 enhanced the rSmD1-specific T cell response. SmD1(83-119)-specific T cell reactivity was significantly more common in patients with cardiac and pulmonary symptoms. No correlation between T and B cell responses and disease activity was seen.SmD1(83-119) is a major T cell epitope of SmD1, commonly recognised by T cells from patients with SLE and much less commonly found by healthy or disease controls. This strong T cell reactivity as well as the high frequency and specificity of anti-SmD1(83-119) antibodies in SLE suggest a possible role in SLE pathogenesis, at least in a subset of patients." @default.
• W2129778857 created "2016-06-24" @default.
• W2129778857 creator A5014912299 @default.
• W2129778857 creator A5017467815 @default.
• W2129778857 creator A5019819777 @default.
• W2129778857 creator A5021701563 @default.
• W2129778857 creator A5044082622 @default.
• W2129778857 creator A5044174191 @default.
• W2129778857 creator A5048156942 @default.
• W2129778857 creator A5050645185 @default.
• W2129778857 creator A5053515753 @default.
• W2129778857 date "2002-09-01" @default.
• W2129778857 modified "2023-10-12" @default.
• W2129778857 title "T cell reactivity against the SmD183-119 C terminal peptide in patients with systemic lupus erythematosus" @default.
• W2129778857 cites W1552738427 @default.
• W2129778857 cites W1564770796 @default.
• W2129778857 cites W1590473665 @default.
• W2129778857 cites W1596927028 @default.
• W2129778857 cites W190325642 @default.
• W2129778857 cites W1991882299 @default.
• W2129778857 cites W2000293943 @default.
• W2129778857 cites W2011486018 @default.
• W2129778857 cites W2013061583 @default.
• W2129778857 cites W2018100047 @default.
• W2129778857 cites W2025973568 @default.
• W2129778857 cites W2029567705 @default.
• W2129778857 cites W2043499471 @default.
• W2129778857 cites W2043675278 @default.
• W2129778857 cites W2044572322 @default.
• W2129778857 cites W2045832905 @default.
• W2129778857 cites W2054678965 @default.
• W2129778857 cites W2060467993 @default.
• W2129778857 cites W2062372816 @default.
• W2129778857 cites W2064999867 @default.
• W2129778857 cites W2067030201 @default.
• W2129778857 cites W2072618576 @default.
• W2129778857 cites W2073559712 @default.
• W2129778857 cites W2092604360 @default.
• W2129778857 cites W2117806308 @default.
• W2129778857 cites W2121359611 @default.
• W2129778857 cites W2146203649 @default.
• W2129778857 cites W2151655504 @default.
• W2129778857 cites W2152348310 @default.
• W2129778857 cites W2163251224 @default.
• W2129778857 cites W2167941738 @default.
• W2129778857 cites W2279295758 @default.
• W2129778857 cites W2413954831 @default.
• W2129778857 cites W65590908 @default.
• W2129778857 doi "https://doi.org/10.1136/ard.61.9.779" @default.
• W2129778857 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1754211" @default.
• W2129778857 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12176801" @default.
• W2129778857 hasPublicationYear "2002" @default.
• W2129778857 type Work @default.
• W2129778857 sameAs 2129778857 @default.
• W2129778857 citedByCount "21" @default.
• W2129778857 countsByYear W21297788572020 @default.
• W2129778857 countsByYear W21297788572021 @default.
• W2129778857 countsByYear W21297788572022 @default.
• W2129778857 crossrefType "journal-article" @default.
• W2129778857 hasAuthorship W2129778857A5014912299 @default.
• W2129778857 hasAuthorship W2129778857A5017467815 @default.
• W2129778857 hasAuthorship W2129778857A5019819777 @default.
• W2129778857 hasAuthorship W2129778857A5021701563 @default.
• W2129778857 hasAuthorship W2129778857A5044082622 @default.
• W2129778857 hasAuthorship W2129778857A5044174191 @default.
• W2129778857 hasAuthorship W2129778857A5048156942 @default.
• W2129778857 hasAuthorship W2129778857A5050645185 @default.
• W2129778857 hasAuthorship W2129778857A5053515753 @default.
• W2129778857 hasBestOaLocation W21297788571 @default.
• W2129778857 hasConcept C137061746 @default.
• W2129778857 hasConcept C1491633281 @default.
• W2129778857 hasConcept C159654299 @default.
• W2129778857 hasConcept C163764329 @default.
• W2129778857 hasConcept C195616568 @default.
• W2129778857 hasConcept C202751555 @default.
• W2129778857 hasConcept C203014093 @default.
• W2129778857 hasConcept C2775915377 @default.
• W2129778857 hasConcept C2776090121 @default.
• W2129778857 hasConcept C2780130043 @default.
• W2129778857 hasConcept C2780380361 @default.
• W2129778857 hasConcept C2780942790 @default.
• W2129778857 hasConcept C55493867 @default.
• W2129778857 hasConcept C71924100 @default.
• W2129778857 hasConcept C86803240 @default.
• W2129778857 hasConcept C8891405 @default.
• W2129778857 hasConceptScore W2129778857C137061746 @default.
• W2129778857 hasConceptScore W2129778857C1491633281 @default.
• W2129778857 hasConceptScore W2129778857C159654299 @default.
• W2129778857 hasConceptScore W2129778857C163764329 @default.
• W2129778857 hasConceptScore W2129778857C195616568 @default.
• W2129778857 hasConceptScore W2129778857C202751555 @default.
• W2129778857 hasConceptScore W2129778857C203014093 @default.
• W2129778857 hasConceptScore W2129778857C2775915377 @default.
• W2129778857 hasConceptScore W2129778857C2776090121 @default.
• W2129778857 hasConceptScore W2129778857C2780130043 @default.
• W2129778857 hasConceptScore W2129778857C2780380361 @default.
• W2129778857 hasConceptScore W2129778857C2780942790 @default.
• W2129778857 hasConceptScore W2129778857C55493867 @default.

• next