FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2129778899> ?p ?o ?g. }

• W2129778899 endingPage "2196" @default.
• W2129778899 startingPage "2187" @default.
• W2129778899 abstract "Epidemiological, clinical or animal studies have suggested an inverse association between the consumption of polyphenol and polyphenol-rich foods or beverages and the prevention of diseases. Previously, the following effects have been shown on flavonoids from the black elderberry, Sambucus nigra, on cells. Quercetin: apoptosis induction, antioxidant, protein kinase inhibitor, interaction with type II oestrogen-binding site. Chrysin: aromatase inhibitor and apoptosis-induction affect PPAR alpha and synthetic analogue: dihydroxy-8-nitrochrysin (NOC) = apoptosis-induction. Kaempferol: induction of apoptosis, cell proliferation, and reduction in ER-alpha mRNA. Naringenin: cell proliferation. Hesperidin: cell proliferation. The question now arises as to whether the flavonoids, quercetin, chrysin, kaempferol, naringenin and hesperidin are candidates for primary and secondary cancer prevention. The effect of crude extracts of elderflower and elderberries and the aforementioned flavonoids at concentrations of 5, 10, 20 and 50 µg/ml on vitality parameters of the breast cancer cell lines MCF-7 (ER α +, ER β +) and BT20 (ER α-, ER β-) was demonstrated. Cell proliferation (BrdU assay), mitochondrial activity (MTT assay) and cytotoxicity (LDH assay) were examined. Elderflower crude extract inhibits cell proliferation of MCF-7 (62%) and BT20 (10%) cells. Elderberry crude extract inhibits cell proliferation in MCF-7 (50%) cells and proliferation in BT20 (20%) cells. Quercetin, chrysin, kaempferol, naringenin and hesperidin inhibit proliferation in MCF-7 (quercetin, 50 µg/ml (22%); chrysin, 50 µg/ml (30%); kaempferol, 5 µg/ml (36%); naringenin, 5 µg/ml (25%); hesperidin, 5 and 10 µg/ml (21%) and BT20 (quercetin, 5 µg/ml (18%); chrysin, 10 and 50 µg/ml (8%); kaempferol, 20 µg/ml (15%); naringenin, 5 and 50 µg/ml (20%); hesperidin, 5 and 10 µg/ml (14%)) cells, no cytotoxicity, and little effect on mitochondrial activity.   Key words: Sambucus nigra, polyphenols, breast cancer, LC-MS analysis." @default.
• W2129778899 created "2016-06-24" @default.
• W2129778899 creator A5001494583 @default.
• W2129778899 creator A5027244753 @default.
• W2129778899 creator A5037850892 @default.
• W2129778899 creator A5038172594 @default.
• W2129778899 creator A5041267529 @default.
• W2129778899 date "2013-08-03" @default.
• W2129778899 modified "2023-09-30" @default.
• W2129778899 title "Polyphenol compounds with anti-carcinogenic qualities: Effects of quercetin (flavonol), chrysin (flavon), kaempferol (flavanol), naringenin (flavanon) and hesperidin (flavanoid) on in vitro breast cancer" @default.
• W2129778899 cites W1965496422 @default.
• W2129778899 cites W1979529425 @default.
• W2129778899 cites W1980414939 @default.
• W2129778899 cites W1982472213 @default.
• W2129778899 cites W1983606163 @default.
• W2129778899 cites W1984294349 @default.
• W2129778899 cites W2025655864 @default.
• W2129778899 cites W2026555821 @default.
• W2129778899 cites W2029433783 @default.
• W2129778899 cites W2040288406 @default.
• W2129778899 cites W2050477291 @default.
• W2129778899 cites W2051376250 @default.
• W2129778899 cites W2051861797 @default.
• W2129778899 cites W2052443776 @default.
• W2129778899 cites W2069192207 @default.
• W2129778899 cites W2069858164 @default.
• W2129778899 cites W2082812540 @default.
• W2129778899 cites W2085083111 @default.
• W2129778899 cites W2090102281 @default.
• W2129778899 cites W2106788905 @default.
• W2129778899 cites W2112916870 @default.
• W2129778899 cites W2116252316 @default.
• W2129778899 cites W2128530258 @default.
• W2129778899 cites W2131753291 @default.
• W2129778899 cites W2136506025 @default.
• W2129778899 cites W2137143396 @default.
• W2129778899 cites W2145545413 @default.
• W2129778899 cites W2145560864 @default.
• W2129778899 cites W2530618749 @default.
• W2129778899 doi "https://doi.org/10.5897/jmpr12.5126" @default.
• W2129778899 hasPublicationYear "2013" @default.
• W2129778899 type Work @default.
• W2129778899 sameAs 2129778899 @default.
• W2129778899 citedByCount "10" @default.
• W2129778899 countsByYear W21297788992013 @default.
• W2129778899 countsByYear W21297788992014 @default.
• W2129778899 countsByYear W21297788992015 @default.
• W2129778899 countsByYear W21297788992016 @default.
• W2129778899 countsByYear W21297788992017 @default.
• W2129778899 countsByYear W21297788992018 @default.
• W2129778899 countsByYear W21297788992020 @default.
• W2129778899 countsByYear W21297788992021 @default.
• W2129778899 crossrefType "journal-article" @default.
• W2129778899 hasAuthorship W2129778899A5001494583 @default.
• W2129778899 hasAuthorship W2129778899A5027244753 @default.
• W2129778899 hasAuthorship W2129778899A5037850892 @default.
• W2129778899 hasAuthorship W2129778899A5038172594 @default.
• W2129778899 hasAuthorship W2129778899A5041267529 @default.
• W2129778899 hasBestOaLocation W21297788991 @default.
• W2129778899 hasConcept C134018914 @default.
• W2129778899 hasConcept C142724271 @default.
• W2129778899 hasConcept C185592680 @default.
• W2129778899 hasConcept C190283241 @default.
• W2129778899 hasConcept C204787440 @default.
• W2129778899 hasConcept C2776128092 @default.
• W2129778899 hasConcept C2776848411 @default.
• W2129778899 hasConcept C2777810353 @default.
• W2129778899 hasConcept C2778004101 @default.
• W2129778899 hasConcept C2778298627 @default.
• W2129778899 hasConcept C2779054382 @default.
• W2129778899 hasConcept C2779478871 @default.
• W2129778899 hasConcept C2780783641 @default.
• W2129778899 hasConcept C2781263971 @default.
• W2129778899 hasConcept C55493867 @default.
• W2129778899 hasConcept C62112901 @default.
• W2129778899 hasConcept C71924100 @default.
• W2129778899 hasConcept C86803240 @default.
• W2129778899 hasConcept C98274493 @default.
• W2129778899 hasConceptScore W2129778899C134018914 @default.
• W2129778899 hasConceptScore W2129778899C142724271 @default.
• W2129778899 hasConceptScore W2129778899C185592680 @default.
• W2129778899 hasConceptScore W2129778899C190283241 @default.
• W2129778899 hasConceptScore W2129778899C204787440 @default.
• W2129778899 hasConceptScore W2129778899C2776128092 @default.
• W2129778899 hasConceptScore W2129778899C2776848411 @default.
• W2129778899 hasConceptScore W2129778899C2777810353 @default.
• W2129778899 hasConceptScore W2129778899C2778004101 @default.
• W2129778899 hasConceptScore W2129778899C2778298627 @default.
• W2129778899 hasConceptScore W2129778899C2779054382 @default.
• W2129778899 hasConceptScore W2129778899C2779478871 @default.
• W2129778899 hasConceptScore W2129778899C2780783641 @default.
• W2129778899 hasConceptScore W2129778899C2781263971 @default.
• W2129778899 hasConceptScore W2129778899C55493867 @default.
• W2129778899 hasConceptScore W2129778899C62112901 @default.
• W2129778899 hasConceptScore W2129778899C71924100 @default.
• W2129778899 hasConceptScore W2129778899C86803240 @default.
• W2129778899 hasConceptScore W2129778899C98274493 @default.
• W2129778899 hasIssue "29" @default.

• next