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• W2129781246 abstract "The aim of this study was to evaluate the effect of vitamin C towards N-nitrosopyrrolidine (NPYR)- and N-nitrosodimethylamine (NDMA)-induced apoptosis in human hepatoma (HepG2) and leukemia (HL-60) cell lines using flow cytometry analysis and the terminal deoxynucleotidyl transferase-mediated dUTP nick end labelling assay (TUNEL). None of the vitamin C concentrations tested (1–100 µm) caused cytotoxicity in HepG2 cells. However, there were significant losses of HL-60 cells viability, measured by MTT assay, 72 h after treatment with 50 and 100 µm vitamin C (29 and 46%, respectively). Moreover, an increase of lactate dehydrogenase release was significant with 50 µm at 72 h (28%) and with 100 µm of vitamin C at 48 and 72 h (27 and 36%, respectively). Also, the percentage of apoptotic HL-60 cells found in TUNEL assay increased to 21% when they were treated with 100 µm vitamin C for 72 h. Thus, in subsequent simultaneous treatments with NPYR (30 and 50 mm) or NDMA (27 and 68 mm) and vitamin C, concentrations of 5–50 µm vitamin C were used. Our results revealed that vitamin C, at all concentrations and times tested, reduced the apoptosis induced by NPYR and NDMA in both cell lines, showing a similar effect in HepG2 and HL-60 cells towards NPYR (50 mm) — 65 and 63% of reduction, respectively — whereas towards NDMA (27 mm) the inhibition was higher in HL-60 than in HepG2 cells — 75 and 57%, respectively. Therefore, our findings suggest that inhibition of apoptosis may be one of the mechanisms by which vitamin C exerts its protective effect. Copyright © 2008 John Wiley & Sons, Ltd." @default.
• W2129781246 created "2016-06-24" @default.
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• W2129781246 date "2008-08-01" @default.
• W2129781246 modified "2023-10-17" @default.
• W2129781246 title "Inhibition by vitamin C of apoptosis induced by<i>N</i>-nitrosamines in HepG2 and HL-60 cells" @default.
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• W2129781246 cites W1967510771 @default.
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• W2129781246 cites W1972780893 @default.
• W2129781246 cites W1973349116 @default.
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• W2129781246 cites W2026602611 @default.
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• W2129781246 cites W2059008019 @default.
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• W2129781246 cites W2060909573 @default.
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• W2129781246 doi "https://doi.org/10.1002/jat.1340" @default.
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• W2129781246 hasPublicationYear "2008" @default.
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