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• W2129786180 endingPage "571" @default.
• W2129786180 startingPage "561" @default.
• W2129786180 abstract "The recent availability of specific inhibin assays has demonstrated that inhibin B is the relevant circulating inhibin form in the human male. Inhibin B is a dimer of an alpha and a betaB subunit. It is produced exclusively by the testis, predominantly by the Sertoli cells in the prepubertal testis, while the site of production in the adult is still controversial. Inhibin B controls FSH secretion via a negative feedback mechanism. In the adult, inhibin B production depends both on FSH and on spermatogenic status, but it is not known in which way germ cells contribute to inhibin B production. The regulation of inhibin B production changes during life. There is an inhibin B peak in serum shortly after birth only partly correlated with an increase in serum FSH, probably reflecting the proliferating activity of the Sertoli cells during this phase of life. Afterwards, inhibin B levels decrease and remain low until puberty, when they rise again, first as a consequence of FSH stimulation and then as a result of the combined regulation by FSH and the ongoing spermatogenesis. In the adult, serum inhibin B shows a clear diurnal variation closely related to that of testosterone. The administration of FSH increases the secretion of inhibin B in normal men, but is much more pronounced in males with secondary hypogonadism. The treatment of infertile men with FSH, however, does not result in an unequivocal inhibin B increase. There is a clear inverse relationship between serum inhibin B and FSH in the adult. Serum inhibin B levels are strongly positively correlated with testicular volume and sperm counts. In infertile patients, inhibin B decreases and FSH increases. In general, there is very good correlation with the degree of spermatogenetic damage, with the arrest at the earlier stages having the lowest inhibin B levels. However, for unknown reasons, there are cases of Sertoli-cell-only syndrome with normal inhibin B levels. Inhibin B and FSH together are a more sensitive and specific marker for spermatogenesis than either one alone. However, the inhibin B concentrations are not a reliable predictor of the presence of sperm in biopsy samples for testicular sperm extraction. Suppression of spermatogenesis with testosterone and gestagens leads to a partial reduction of inhibin B in serum but it is never completely suppressed. In contrast, testicular irradiation in monkeys or humans leads to a rapid and dramatic decrease of inhibin B, which becomes undetectable when germ cells are completely absent. In summary, although inhibin B is a valuable index of spermatogenesis, the measurement of serum inhibin B levels is still of limited clinical relevance for individual patients." @default.
• W2129786180 created "2016-06-24" @default.
• W2129786180 creator A5016538424 @default.
• W2129786180 creator A5067390119 @default.
• W2129786180 creator A5089212670 @default.
• W2129786180 date "2001-11-01" @default.
• W2129786180 modified "2023-09-30" @default.
• W2129786180 title "Inhibin B in male reproduction: pathophysiology and clinical relevance" @default.
• W2129786180 cites W1506411834 @default.
• W2129786180 cites W1541928038 @default.
• W2129786180 cites W1563936679 @default.
• W2129786180 cites W1952016525 @default.
• W2129786180 cites W1966438764 @default.
• W2129786180 cites W1967165126 @default.
• W2129786180 cites W1967199568 @default.
• W2129786180 cites W1968773008 @default.
• W2129786180 cites W1968993020 @default.
• W2129786180 cites W1974281007 @default.
• W2129786180 cites W1974407225 @default.
• W2129786180 cites W1975355193 @default.
• W2129786180 cites W1977165893 @default.
• W2129786180 cites W1978779704 @default.
• W2129786180 cites W1985334749 @default.
• W2129786180 cites W1988232752 @default.
• W2129786180 cites W1991561219 @default.
• W2129786180 cites W1991618066 @default.
• W2129786180 cites W1991651188 @default.
• W2129786180 cites W1996202698 @default.
• W2129786180 cites W1996709504 @default.
• W2129786180 cites W2002049550 @default.
• W2129786180 cites W2006773703 @default.
• W2129786180 cites W2012044438 @default.
• W2129786180 cites W2013581704 @default.
• W2129786180 cites W2017094054 @default.
• W2129786180 cites W2017629282 @default.
• W2129786180 cites W2019096168 @default.
• W2129786180 cites W2021140704 @default.
• W2129786180 cites W2024137700 @default.
• W2129786180 cites W2025198675 @default.
• W2129786180 cites W2025395169 @default.
• W2129786180 cites W2026981868 @default.
• W2129786180 cites W2027522939 @default.
• W2129786180 cites W2029499458 @default.
• W2129786180 cites W2029514922 @default.
• W2129786180 cites W2033858443 @default.
• W2129786180 cites W2034427531 @default.
• W2129786180 cites W2034438484 @default.
• W2129786180 cites W2036509369 @default.
• W2129786180 cites W2043739959 @default.
• W2129786180 cites W2044463952 @default.
• W2129786180 cites W2045206957 @default.
• W2129786180 cites W2046037958 @default.
• W2129786180 cites W2047119340 @default.
• W2129786180 cites W2047244262 @default.
• W2129786180 cites W2050616828 @default.
• W2129786180 cites W2051312404 @default.
• W2129786180 cites W2051771413 @default.
• W2129786180 cites W2060111268 @default.
• W2129786180 cites W2061489813 @default.
• W2129786180 cites W2063443812 @default.
• W2129786180 cites W2064293533 @default.
• W2129786180 cites W2065237785 @default.
• W2129786180 cites W2065599061 @default.
• W2129786180 cites W2066062275 @default.
• W2129786180 cites W2066524070 @default.
• W2129786180 cites W2072656953 @default.
• W2129786180 cites W2079465697 @default.
• W2129786180 cites W2085828113 @default.
• W2129786180 cites W2087200050 @default.
• W2129786180 cites W2087864326 @default.
• W2129786180 cites W2090227492 @default.
• W2129786180 cites W2093943347 @default.
• W2129786180 cites W2094945489 @default.
• W2129786180 cites W2100400397 @default.
• W2129786180 cites W2100996498 @default.
• W2129786180 cites W2104642917 @default.
• W2129786180 cites W2104680997 @default.
• W2129786180 cites W2109974307 @default.
• W2129786180 cites W2117533526 @default.
• W2129786180 cites W2117542108 @default.
• W2129786180 cites W2118098792 @default.
• W2129786180 cites W2121754658 @default.
• W2129786180 cites W2121970442 @default.
• W2129786180 cites W2123707906 @default.
• W2129786180 cites W2125237869 @default.
• W2129786180 cites W2128012413 @default.
• W2129786180 cites W2131670695 @default.
• W2129786180 cites W2132392207 @default.
• W2129786180 cites W2137404188 @default.
• W2129786180 cites W2140401236 @default.
• W2129786180 cites W2151801226 @default.
• W2129786180 cites W2154330686 @default.
• W2129786180 cites W2154600285 @default.
• W2129786180 cites W2155492518 @default.
• W2129786180 cites W2157294911 @default.
• W2129786180 cites W2165301454 @default.
• W2129786180 cites W2165909254 @default.
• W2129786180 cites W2166403740 @default.

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