FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2129789808> ?p ?o ?g. }

• W2129789808 endingPage "1839" @default.
• W2129789808 startingPage "1829" @default.
• W2129789808 abstract "RATIONALE Glucocorticosteroids are prohibited in sports when used by systemic administrations (e.g. intramuscular, IM), whereas they are allowed using other ways of administration. Strategies to discriminate between administrations routes have to be developed by doping control laboratories. For this reason, the metabolism of triamcinolone acetonide (TA), one of the most used glucocorticosteroids, was studied using liquid chromatography coupled to tandem mass spectrometry (LC/MS/MS). METHODS Urine samples obtained after IM administration of TA were analyzed using two sample treatments: (a) hydrolysis with β-glucuronidase enzymes and liquid-liquid extraction under alkaline conditions, and (b) liquid-liquid extraction under acidic conditions. The extracts were analyzed by LC/MS/MS. RESULTS TA, commercially available metabolites (6β-hydroxytriamcinolone acetonide, 6β-OH-TA, and triamcinolone), and their C20-reduced derivatives showed characteristic fragmentation behavior. Besides common product ions and neutral losses for corticosteroids containing fluorine, additional characteristic neutral losses (58 Da, loss of acetone; 44 Da, loss of acetaldehyde) were observed in positive electrospray ionization. Based on that behavior, two complementary approaches were applied to detect TA metabolites: (a) open detection by precursor ion and neutral loss scan methods and (b) targeted detection by selected reaction monitoring methods (SRM) containing theoretical ion transitions of the potential metabolites. Two main compounds, TA and 6β-OH-TA, and nine minor potential metabolites, were detected by open screening methods. Using SRM, two additional metabolites were detected. Some of the metabolites were characterized using reference standards and, for the rest of metabolites, feasible structures were proposed based on mass spectrometric data. CONCLUSIONS Metabolites resulting from hydroxylation in C-6, oxidation of the 11-hydroxyl group, reduction of the Δ4 double bond and oxidation of the side chain were detected. Some of them have not been previously described. Excretion profiles of the detected metabolites after IM administration are presented. Copyright © 2014 John Wiley & Sons, Ltd." @default.
• W2129789808 created "2016-06-24" @default.
• W2129789808 creator A5030310437 @default.
• W2129789808 creator A5033049869 @default.
• W2129789808 creator A5033539160 @default.
• W2129789808 creator A5038134435 @default.
• W2129789808 creator A5058384218 @default.
• W2129789808 creator A5066941946 @default.
• W2129789808 creator A5089686510 @default.
• W2129789808 date "2014-07-01" @default.
• W2129789808 modified "2023-10-06" @default.
• W2129789808 title "Detection and characterization of triamcinolone acetonide metabolites in human urine by liquid chromatography/tandem mass spectrometry after intramuscular administration" @default.
• W2129789808 cites W1933183331 @default.
• W2129789808 cites W1991174440 @default.
• W2129789808 cites W1992699787 @default.
• W2129789808 cites W1997277260 @default.
• W2129789808 cites W1997369736 @default.
• W2129789808 cites W2006323464 @default.
• W2129789808 cites W2013461007 @default.
• W2129789808 cites W2018086190 @default.
• W2129789808 cites W2020660612 @default.
• W2129789808 cites W2021133894 @default.
• W2129789808 cites W2030621504 @default.
• W2129789808 cites W2035495051 @default.
• W2129789808 cites W2063260461 @default.
• W2129789808 cites W2063330572 @default.
• W2129789808 cites W2064150906 @default.
• W2129789808 cites W2066040601 @default.
• W2129789808 cites W2071308799 @default.
• W2129789808 cites W2092424456 @default.
• W2129789808 cites W2104408712 @default.
• W2129789808 cites W2116446494 @default.
• W2129789808 cites W2118613081 @default.
• W2129789808 cites W2138099852 @default.
• W2129789808 cites W2316567524 @default.
• W2129789808 cites W2320702531 @default.
• W2129789808 cites W4230165723 @default.
• W2129789808 doi "https://doi.org/10.1002/rcm.6965" @default.
• W2129789808 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25559453" @default.
• W2129789808 hasPublicationYear "2014" @default.
• W2129789808 type Work @default.
• W2129789808 sameAs 2129789808 @default.
• W2129789808 citedByCount "20" @default.
• W2129789808 countsByYear W21297898082014 @default.
• W2129789808 countsByYear W21297898082015 @default.
• W2129789808 countsByYear W21297898082016 @default.
• W2129789808 countsByYear W21297898082017 @default.
• W2129789808 countsByYear W21297898082018 @default.
• W2129789808 countsByYear W21297898082019 @default.
• W2129789808 countsByYear W21297898082020 @default.
• W2129789808 countsByYear W21297898082023 @default.
• W2129789808 crossrefType "journal-article" @default.
• W2129789808 hasAuthorship W2129789808A5030310437 @default.
• W2129789808 hasAuthorship W2129789808A5033049869 @default.
• W2129789808 hasAuthorship W2129789808A5033539160 @default.
• W2129789808 hasAuthorship W2129789808A5038134435 @default.
• W2129789808 hasAuthorship W2129789808A5058384218 @default.
• W2129789808 hasAuthorship W2129789808A5066941946 @default.
• W2129789808 hasAuthorship W2129789808A5089686510 @default.
• W2129789808 hasConcept C141071460 @default.
• W2129789808 hasConcept C162356407 @default.
• W2129789808 hasConcept C185592680 @default.
• W2129789808 hasConcept C2778903070 @default.
• W2129789808 hasConcept C2780026642 @default.
• W2129789808 hasConcept C31827203 @default.
• W2129789808 hasConcept C40684141 @default.
• W2129789808 hasConcept C43617362 @default.
• W2129789808 hasConcept C55493867 @default.
• W2129789808 hasConcept C64489805 @default.
• W2129789808 hasConcept C71043704 @default.
• W2129789808 hasConcept C71924100 @default.
• W2129789808 hasConceptScore W2129789808C141071460 @default.
• W2129789808 hasConceptScore W2129789808C162356407 @default.
• W2129789808 hasConceptScore W2129789808C185592680 @default.
• W2129789808 hasConceptScore W2129789808C2778903070 @default.
• W2129789808 hasConceptScore W2129789808C2780026642 @default.
• W2129789808 hasConceptScore W2129789808C31827203 @default.
• W2129789808 hasConceptScore W2129789808C40684141 @default.
• W2129789808 hasConceptScore W2129789808C43617362 @default.
• W2129789808 hasConceptScore W2129789808C55493867 @default.
• W2129789808 hasConceptScore W2129789808C64489805 @default.
• W2129789808 hasConceptScore W2129789808C71043704 @default.
• W2129789808 hasConceptScore W2129789808C71924100 @default.
• W2129789808 hasFunder F4320321505 @default.
• W2129789808 hasIssue "16" @default.
• W2129789808 hasLocation W21297898081 @default.
• W2129789808 hasLocation W21297898082 @default.
• W2129789808 hasOpenAccess W2129789808 @default.
• W2129789808 hasPrimaryLocation W21297898081 @default.
• W2129789808 hasRelatedWork W1277187992 @default.
• W2129789808 hasRelatedWork W1863131412 @default.
• W2129789808 hasRelatedWork W1979998703 @default.
• W2129789808 hasRelatedWork W2012075101 @default.
• W2129789808 hasRelatedWork W2021034129 @default.
• W2129789808 hasRelatedWork W2062375825 @default.
• W2129789808 hasRelatedWork W2200897360 @default.
• W2129789808 hasRelatedWork W2385607342 @default.
• W2129789808 hasRelatedWork W2979742567 @default.

• next