FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2129796323> ?p ?o ?g. }

• W2129796323 endingPage "2186" @default.
• W2129796323 startingPage "2181" @default.
• W2129796323 abstract "Purpose The purpose of this study was to evaluate the clinical, pathological, and therapeutic experience of a group of patients with primary oral malignant melanoma (OMM) in Amsterdam, The Netherlands. Patients and Methods Fourteen patients (5 males, 9 females, mean age 57.9 years) with histopathologic diagnosis of OMM were treated at the Department of Oral and Maxillofacial Surgery/Oral Pathology of the Vrije University Medical Center in Amsterdam between 1978 and 2005. A pigmented, flat or swollen, irregularly bordered lesion of oral mucosa was detected in most patients during the first clinical examination. Pain was the most commonly referred symptom; the palate was the most frequently affected subsite. Following the mucosal melanoma microstaging system, all patients staged as stage I (T any N0M0) could be subclassified as microstage II (invasion up to the lamina propria), except for 1 patient microstaged as stage III (deep skeletal tissue invasion into skeletal muscle, bone, or cartilage). Where possible, surgery was the treatment of choice. Postoperative radiotherapy, using fractions of 6 Gy twice a week for a total dose of 30 Gy, was given to 3 patients. Three patients were treated primarily with radiotherapy alone. Results Five patients developed local recurrence within 4 to 72 months, and 10 patients developed distant metastases within 6 to 78 months. Ten patients died of their disease within an average interval of 40 months, with a range of 12 to 80 months. Of the 10 patients who qualified for evaluation of the 5-year-survival rate, 1 was alive with disease and 2 were alive without evidence of disease, resulting in a 5-year survival rate of 30%. However, all patients died of their disease before the end of the 10-year follow-up period. Conclusion Our study confirms that OMM is a rare and aggressive malignancy with a low 5-year survival rate. An evidence-based protocol for the best therapeutic approach is not yet available. The purpose of this study was to evaluate the clinical, pathological, and therapeutic experience of a group of patients with primary oral malignant melanoma (OMM) in Amsterdam, The Netherlands. Fourteen patients (5 males, 9 females, mean age 57.9 years) with histopathologic diagnosis of OMM were treated at the Department of Oral and Maxillofacial Surgery/Oral Pathology of the Vrije University Medical Center in Amsterdam between 1978 and 2005. A pigmented, flat or swollen, irregularly bordered lesion of oral mucosa was detected in most patients during the first clinical examination. Pain was the most commonly referred symptom; the palate was the most frequently affected subsite. Following the mucosal melanoma microstaging system, all patients staged as stage I (T any N0M0) could be subclassified as microstage II (invasion up to the lamina propria), except for 1 patient microstaged as stage III (deep skeletal tissue invasion into skeletal muscle, bone, or cartilage). Where possible, surgery was the treatment of choice. Postoperative radiotherapy, using fractions of 6 Gy twice a week for a total dose of 30 Gy, was given to 3 patients. Three patients were treated primarily with radiotherapy alone. Five patients developed local recurrence within 4 to 72 months, and 10 patients developed distant metastases within 6 to 78 months. Ten patients died of their disease within an average interval of 40 months, with a range of 12 to 80 months. Of the 10 patients who qualified for evaluation of the 5-year-survival rate, 1 was alive with disease and 2 were alive without evidence of disease, resulting in a 5-year survival rate of 30%. However, all patients died of their disease before the end of the 10-year follow-up period. Our study confirms that OMM is a rare and aggressive malignancy with a low 5-year survival rate. An evidence-based protocol for the best therapeutic approach is not yet available." @default.
• W2129796323 created "2016-06-24" @default.
• W2129796323 creator A5002495127 @default.
• W2129796323 creator A5045970624 @default.
• W2129796323 creator A5065147823 @default.
• W2129796323 creator A5070012126 @default.
• W2129796323 date "2007-11-01" @default.
• W2129796323 modified "2023-10-12" @default.
• W2129796323 title "Oral Malignant Melanoma: The Amsterdam Experience" @default.
• W2129796323 cites W1545177819 @default.
• W2129796323 cites W1691315915 @default.
• W2129796323 cites W1974514411 @default.
• W2129796323 cites W1975677215 @default.
• W2129796323 cites W1984408439 @default.
• W2129796323 cites W1990365815 @default.
• W2129796323 cites W1996936568 @default.
• W2129796323 cites W1997516985 @default.
• W2129796323 cites W1997684002 @default.
• W2129796323 cites W2005236724 @default.
• W2129796323 cites W2025973123 @default.
• W2129796323 cites W2032617634 @default.
• W2129796323 cites W2033087055 @default.
• W2129796323 cites W2034058457 @default.
• W2129796323 cites W2042369801 @default.
• W2129796323 cites W2043307297 @default.
• W2129796323 cites W2061013540 @default.
• W2129796323 cites W2061752514 @default.
• W2129796323 cites W2067667773 @default.
• W2129796323 cites W2067770470 @default.
• W2129796323 cites W2073401994 @default.
• W2129796323 cites W2077984965 @default.
• W2129796323 cites W2080801215 @default.
• W2129796323 cites W2084189140 @default.
• W2129796323 cites W2094946796 @default.
• W2129796323 cites W2095510357 @default.
• W2129796323 cites W2101581870 @default.
• W2129796323 cites W2105702618 @default.
• W2129796323 cites W2112766682 @default.
• W2129796323 cites W2118822811 @default.
• W2129796323 cites W2123903509 @default.
• W2129796323 cites W2126671243 @default.
• W2129796323 cites W2132670002 @default.
• W2129796323 cites W2149184338 @default.
• W2129796323 cites W2158323129 @default.
• W2129796323 cites W2167557226 @default.
• W2129796323 cites W2169897410 @default.
• W2129796323 cites W2315295761 @default.
• W2129796323 cites W2022809576 @default.
• W2129796323 doi "https://doi.org/10.1016/j.joms.2006.10.044" @default.
• W2129796323 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17954312" @default.
• W2129796323 hasPublicationYear "2007" @default.
• W2129796323 type Work @default.
• W2129796323 sameAs 2129796323 @default.
• W2129796323 citedByCount "40" @default.
• W2129796323 countsByYear W21297963232012 @default.
• W2129796323 countsByYear W21297963232013 @default.
• W2129796323 countsByYear W21297963232014 @default.
• W2129796323 countsByYear W21297963232015 @default.
• W2129796323 countsByYear W21297963232016 @default.
• W2129796323 countsByYear W21297963232017 @default.
• W2129796323 countsByYear W21297963232018 @default.
• W2129796323 countsByYear W21297963232019 @default.
• W2129796323 countsByYear W21297963232020 @default.
• W2129796323 countsByYear W21297963232021 @default.
• W2129796323 countsByYear W21297963232022 @default.
• W2129796323 crossrefType "journal-article" @default.
• W2129796323 hasAuthorship W2129796323A5002495127 @default.
• W2129796323 hasAuthorship W2129796323A5045970624 @default.
• W2129796323 hasAuthorship W2129796323A5065147823 @default.
• W2129796323 hasAuthorship W2129796323A5070012126 @default.
• W2129796323 hasConcept C126322002 @default.
• W2129796323 hasConcept C141071460 @default.
• W2129796323 hasConcept C142724271 @default.
• W2129796323 hasConcept C146357865 @default.
• W2129796323 hasConcept C151730666 @default.
• W2129796323 hasConcept C207886595 @default.
• W2129796323 hasConcept C2777310793 @default.
• W2129796323 hasConcept C2777658100 @default.
• W2129796323 hasConcept C2779324799 @default.
• W2129796323 hasConcept C2779409057 @default.
• W2129796323 hasConcept C502942594 @default.
• W2129796323 hasConcept C509974204 @default.
• W2129796323 hasConcept C529295009 @default.
• W2129796323 hasConcept C71924100 @default.
• W2129796323 hasConcept C86803240 @default.
• W2129796323 hasConceptScore W2129796323C126322002 @default.
• W2129796323 hasConceptScore W2129796323C141071460 @default.
• W2129796323 hasConceptScore W2129796323C142724271 @default.
• W2129796323 hasConceptScore W2129796323C146357865 @default.
• W2129796323 hasConceptScore W2129796323C151730666 @default.
• W2129796323 hasConceptScore W2129796323C207886595 @default.
• W2129796323 hasConceptScore W2129796323C2777310793 @default.
• W2129796323 hasConceptScore W2129796323C2777658100 @default.
• W2129796323 hasConceptScore W2129796323C2779324799 @default.
• W2129796323 hasConceptScore W2129796323C2779409057 @default.
• W2129796323 hasConceptScore W2129796323C502942594 @default.
• W2129796323 hasConceptScore W2129796323C509974204 @default.
• W2129796323 hasConceptScore W2129796323C529295009 @default.

• next