FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2129820223> ?p ?o ?g. }

• W2129820223 endingPage "6960" @default.
• W2129820223 startingPage "6953" @default.
• W2129820223 abstract "Activation of the p53 protein can lead to apoptosis and cell cycle arrest. In contrast, activation of the signalling pathway controlled by the Kit receptor tyrosine kinase prevents apoptosis and promotes cell division of a number of different cell types in vivo. We have investigated the consequences of activating the Kit signalling pathway by its ligand Steel factor on these opposing functions of the p53 protein in Friend erythroleukemia cells. A temperature-sensitive p53 allele (Val-135) was introduced into the Friend erythroleukemia cell line (DP-16) which lacks endogenous p53 expression. At 38.5 degrees C, the Val-135 protein maintains a mutant conformation and has no effect on cell growth. At 32 degrees C, the mutant protein assumes wild-type properties and induces these cells to arrest in G1, terminally differentiate, and die by apoptosis. We demonstrate that Steel factor inhibits p53-mediated apoptosis and differentiation but has no effect on p53-mediated G1/S cell cycle arrest. These results demonstrate that Steel factor functions as a cell survival factor in part through the suppression of differentiation and apoptosis induced by p53 and suggest that cell cycle arrest and apoptosis may be separable functions of p53." @default.
• W2129820223 created "2016-06-24" @default.
• W2129820223 creator A5019480876 @default.
• W2129820223 creator A5044125968 @default.
• W2129820223 creator A5063713207 @default.
• W2129820223 date "1995-12-01" @default.
• W2129820223 modified "2023-09-27" @default.
• W2129820223 title "Regulation of p53-Mediated Apoptosis and Cell Cycle Arrest by Steel Factor" @default.
• W2129820223 cites W1484947470 @default.
• W2129820223 cites W1501273614 @default.
• W2129820223 cites W1589415602 @default.
• W2129820223 cites W1591281137 @default.
• W2129820223 cites W161719073 @default.
• W2129820223 cites W1768423394 @default.
• W2129820223 cites W1842375597 @default.
• W2129820223 cites W1924380893 @default.
• W2129820223 cites W1967799899 @default.
• W2129820223 cites W1968625769 @default.
• W2129820223 cites W1977686001 @default.
• W2129820223 cites W1979319210 @default.
• W2129820223 cites W1981391513 @default.
• W2129820223 cites W1983792788 @default.
• W2129820223 cites W1983971803 @default.
• W2129820223 cites W1986162455 @default.
• W2129820223 cites W1986179131 @default.
• W2129820223 cites W1989936068 @default.
• W2129820223 cites W1995856480 @default.
• W2129820223 cites W1999012962 @default.
• W2129820223 cites W2000667274 @default.
• W2129820223 cites W2003282728 @default.
• W2129820223 cites W2005497769 @default.
• W2129820223 cites W2005529016 @default.
• W2129820223 cites W2015026645 @default.
• W2129820223 cites W2015519364 @default.
• W2129820223 cites W2021662066 @default.
• W2129820223 cites W2022272502 @default.
• W2129820223 cites W2039276533 @default.
• W2129820223 cites W2042316019 @default.
• W2129820223 cites W2045086385 @default.
• W2129820223 cites W2046283103 @default.
• W2129820223 cites W2048838478 @default.
• W2129820223 cites W2052437869 @default.
• W2129820223 cites W2055078984 @default.
• W2129820223 cites W2055349083 @default.
• W2129820223 cites W2055933848 @default.
• W2129820223 cites W2058591356 @default.
• W2129820223 cites W2070061120 @default.
• W2129820223 cites W2072489106 @default.
• W2129820223 cites W2074114480 @default.
• W2129820223 cites W2078003307 @default.
• W2129820223 cites W2078581194 @default.
• W2129820223 cites W2079384901 @default.
• W2129820223 cites W2086532812 @default.
• W2129820223 cites W2089218510 @default.
• W2129820223 cites W2102671287 @default.
• W2129820223 cites W2105543043 @default.
• W2129820223 cites W2108172661 @default.
• W2129820223 cites W2125297918 @default.
• W2129820223 cites W2126679757 @default.
• W2129820223 cites W2128060680 @default.
• W2129820223 cites W2134858249 @default.
• W2129820223 cites W2145596465 @default.
• W2129820223 cites W2147242002 @default.
• W2129820223 cites W2148269439 @default.
• W2129820223 cites W2149703879 @default.
• W2129820223 cites W2157721629 @default.
• W2129820223 cites W2170494099 @default.
• W2129820223 cites W2289050278 @default.
• W2129820223 cites W4244105110 @default.
• W2129820223 cites W4253798458 @default.
• W2129820223 doi "https://doi.org/10.1128/mcb.15.12.6953" @default.
• W2129820223 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/230950" @default.
• W2129820223 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8524262" @default.
• W2129820223 hasPublicationYear "1995" @default.
• W2129820223 type Work @default.
• W2129820223 sameAs 2129820223 @default.
• W2129820223 citedByCount "53" @default.
• W2129820223 countsByYear W21298202232012 @default.
• W2129820223 countsByYear W21298202232013 @default.
• W2129820223 countsByYear W21298202232014 @default.
• W2129820223 countsByYear W21298202232015 @default.
• W2129820223 countsByYear W21298202232019 @default.
• W2129820223 crossrefType "journal-article" @default.
• W2129820223 hasAuthorship W2129820223A5019480876 @default.
• W2129820223 hasAuthorship W2129820223A5044125968 @default.
• W2129820223 hasAuthorship W2129820223A5063713207 @default.
• W2129820223 hasBestOaLocation W21298202231 @default.
• W2129820223 hasConcept C105696609 @default.
• W2129820223 hasConcept C1491633281 @default.
• W2129820223 hasConcept C190283241 @default.
• W2129820223 hasConcept C29537977 @default.
• W2129820223 hasConcept C31573885 @default.
• W2129820223 hasConcept C55493867 @default.
• W2129820223 hasConcept C62112901 @default.
• W2129820223 hasConcept C62478195 @default.
• W2129820223 hasConcept C85813293 @default.
• W2129820223 hasConcept C86803240 @default.
• W2129820223 hasConcept C95444343 @default.

• next