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- W2129837211 abstract "In Saccharomyces cerevisiae, the SAC1 gene encodes a polyphosphoinositide phosphatase (PPIPase) that modulates the levels of phosphoinositides, which are key regulators of a number of signal transduction processes. SAC1p has been implicated in multiple cellular functions: actin cytoskeleton organization, secretory functions, inositol metabolism, ATP transport, and multiple-drug sensitivity. Here, we describe the characterization of three genes in Arabidopsis thaliana, AtSAC1a, AtSAC1b, and AtSAC1c, encoding proteins similar to those of yeast SAC1p. We demonstrated that the three AtSAC1 proteins are functional homologs of the yeast SAC1p because they can rescue the cold-sensitive and inositol auxotroph yeast sac1-null mutant strain. The fact that Arabidopsis and yeast SAC1 genes derived from a common ancestor suggests that this plant multigenic family is involved in the phosphoinositide pathway and in a range of cellular functions similar to those in yeast. Using GFP fusion experiments, we demonstrate that the three AtSAC1 proteins are targeted to the endoplasmic reticulum. Their expression patterns are overlapping, with at least two members expressed in each organ. Remarkably, AtSAC1 genes are not expressed during seed development, and therefore additional phosphatases are required to control phosphoinositide levels in seeds." @default.
- W2129837211 created "2016-06-24" @default.
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- W2129837211 date "2003-04-23" @default.
- W2129837211 modified "2023-09-29" @default.
- W2129837211 title "Three SAC1-like genes show overlapping patterns of expression in Arabidopsis but are remarkably silent during embryo development" @default.
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- W2129837211 cites W1973782344 @default.
- W2129837211 cites W1974573437 @default.
- W2129837211 cites W1986267127 @default.
- W2129837211 cites W1988280915 @default.
- W2129837211 cites W1989171518 @default.
- W2129837211 cites W1991792145 @default.
- W2129837211 cites W1997093700 @default.
- W2129837211 cites W1998749044 @default.
- W2129837211 cites W2002961222 @default.
- W2129837211 cites W2004575181 @default.
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- W2129837211 cites W2007885388 @default.
- W2129837211 cites W2028193297 @default.
- W2129837211 cites W2031234701 @default.
- W2129837211 cites W2033959188 @default.
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- W2129837211 cites W2160826161 @default.
- W2129837211 cites W2164417370 @default.
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- W2129837211 doi "https://doi.org/10.1046/j.1365-313x.2003.01720.x" @default.
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