Matches in SemOpenAlex for { <https://semopenalex.org/work/W2129857176> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2129857176 endingPage "350" @default.
- W2129857176 startingPage "347" @default.
- W2129857176 abstract "N-hydroxy-2-acetylaminofluorene (N-OH-AAF) was reduced to 2-acetylaminofluorene by rat liver microsomes in the presence of both NAD(P)H and FAD under anaerobic conditions. The microsomal reduction proceeds as if it were an enzymatic reaction. However, when the microsomes were boiled, the activity was not abolished, but was enhanced. The activity was also observed with cytochrome P450 2B1 alone, without NADPH-cytochrome P450 reductase, in the presence of these cofactors. Hematin also exhibited a significant reducing activity in the presence of both a reduced pyridine nucleotide and FAD. The activities of microsomes, cytochrome P450 2B1 and hematin were also observed upon the addition of photochemically reduced FAD instead of both NAD(P)H and FAD. The microsomal reduction of N-OH-AAF appears to be a non-enzymatic reaction by the reduced flavin, catalyzed by the heme group of cytochrome P450." @default.
- W2129857176 created "2016-06-24" @default.
- W2129857176 creator A5003075118 @default.
- W2129857176 creator A5005424091 @default.
- W2129857176 creator A5043414932 @default.
- W2129857176 creator A5044663343 @default.
- W2129857176 creator A5072721042 @default.
- W2129857176 date "1999-02-01" @default.
- W2129857176 modified "2023-10-05" @default.
- W2129857176 title "Pseudoenzymatic reduction of N-hydroxy-2-acetylaminofluorene to 2-acetylaminofluorene mediated by cytochrome P450" @default.
- W2129857176 cites W122738636 @default.
- W2129857176 cites W1495934178 @default.
- W2129857176 cites W1498570388 @default.
- W2129857176 cites W1527621726 @default.
- W2129857176 cites W1560415434 @default.
- W2129857176 cites W1562777547 @default.
- W2129857176 cites W1579500147 @default.
- W2129857176 cites W1775749144 @default.
- W2129857176 cites W1810385983 @default.
- W2129857176 cites W1844076469 @default.
- W2129857176 cites W192185184 @default.
- W2129857176 cites W1970328167 @default.
- W2129857176 cites W1999306525 @default.
- W2129857176 cites W2006652635 @default.
- W2129857176 cites W2019628849 @default.
- W2129857176 cites W2022628424 @default.
- W2129857176 cites W2038910339 @default.
- W2129857176 cites W2045087169 @default.
- W2129857176 cites W2046083229 @default.
- W2129857176 cites W2046136044 @default.
- W2129857176 cites W2090759326 @default.
- W2129857176 cites W2113784326 @default.
- W2129857176 cites W2114840162 @default.
- W2129857176 cites W2408798039 @default.
- W2129857176 cites W2410909628 @default.
- W2129857176 doi "https://doi.org/10.1093/carcin/20.2.347" @default.
- W2129857176 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10069476" @default.
- W2129857176 hasPublicationYear "1999" @default.
- W2129857176 type Work @default.
- W2129857176 sameAs 2129857176 @default.
- W2129857176 citedByCount "4" @default.
- W2129857176 countsByYear W21298571762013 @default.
- W2129857176 crossrefType "journal-article" @default.
- W2129857176 hasAuthorship W2129857176A5003075118 @default.
- W2129857176 hasAuthorship W2129857176A5005424091 @default.
- W2129857176 hasAuthorship W2129857176A5043414932 @default.
- W2129857176 hasAuthorship W2129857176A5044663343 @default.
- W2129857176 hasAuthorship W2129857176A5072721042 @default.
- W2129857176 hasBestOaLocation W21298571761 @default.
- W2129857176 hasConcept C134651460 @default.
- W2129857176 hasConcept C181199279 @default.
- W2129857176 hasConcept C185592680 @default.
- W2129857176 hasConcept C197957613 @default.
- W2129857176 hasConcept C2776217839 @default.
- W2129857176 hasConcept C2779838395 @default.
- W2129857176 hasConcept C2780768313 @default.
- W2129857176 hasConcept C33093398 @default.
- W2129857176 hasConcept C526171541 @default.
- W2129857176 hasConcept C55493867 @default.
- W2129857176 hasConcept C75520062 @default.
- W2129857176 hasConcept C87644729 @default.
- W2129857176 hasConceptScore W2129857176C134651460 @default.
- W2129857176 hasConceptScore W2129857176C181199279 @default.
- W2129857176 hasConceptScore W2129857176C185592680 @default.
- W2129857176 hasConceptScore W2129857176C197957613 @default.
- W2129857176 hasConceptScore W2129857176C2776217839 @default.
- W2129857176 hasConceptScore W2129857176C2779838395 @default.
- W2129857176 hasConceptScore W2129857176C2780768313 @default.
- W2129857176 hasConceptScore W2129857176C33093398 @default.
- W2129857176 hasConceptScore W2129857176C526171541 @default.
- W2129857176 hasConceptScore W2129857176C55493867 @default.
- W2129857176 hasConceptScore W2129857176C75520062 @default.
- W2129857176 hasConceptScore W2129857176C87644729 @default.
- W2129857176 hasIssue "2" @default.
- W2129857176 hasLocation W21298571761 @default.
- W2129857176 hasLocation W21298571762 @default.
- W2129857176 hasOpenAccess W2129857176 @default.
- W2129857176 hasPrimaryLocation W21298571761 @default.
- W2129857176 hasRelatedWork W1640194603 @default.
- W2129857176 hasRelatedWork W1976609982 @default.
- W2129857176 hasRelatedWork W2015164139 @default.
- W2129857176 hasRelatedWork W2043041864 @default.
- W2129857176 hasRelatedWork W2096667034 @default.
- W2129857176 hasRelatedWork W2125764149 @default.
- W2129857176 hasRelatedWork W2283805667 @default.
- W2129857176 hasRelatedWork W2408884825 @default.
- W2129857176 hasRelatedWork W2462961091 @default.
- W2129857176 hasRelatedWork W281468747 @default.
- W2129857176 hasVolume "20" @default.
- W2129857176 isParatext "false" @default.
- W2129857176 isRetracted "false" @default.
- W2129857176 magId "2129857176" @default.
- W2129857176 workType "article" @default.