FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2129866684> ?p ?o ?g. }

• W2129866684 endingPage "257" @default.
• W2129866684 startingPage "253" @default.
• W2129866684 abstract "Mast cell (MC) hyperplasia and activation are prominent features in Trichinella spiralis infection. Indeed a temporal correlation has been shown between the kinetics of intestinal mastocytosis, release of inflammatory mediators from MC, and adult worm loss, which constitutes a major component of the defense against T. spiralis infection. It is well known that during the intestinal phase of trichinellosis, muscle larvae (ML) and adult worms (AD) enter into contact with the host; however, interaction with MC may also occur during migration of newborn larvae (NBL). Therefore, it is plausible that antigens from these developmental stages could activate MC. We have previously demonstrated by in vitro assays that T. spiralis muscle larval (TSL-1) antigens activate MC through an Ig-independent mechanism leading to the release of histamine, MC protease 5, IL-4 and TNF alpha. In this work we evaluated whether total antigens from AD or NBL could activate unsensitized MC and we compared this activation with the activation seen when MC are stimulated with TSL-1 antigens. MC activation was also tested with affinity chromatography purified antigens from NBL using the monoclonal antibody CE-4 that recognizes NBL surface components. The results obtained in this study showed that AD total extracts and TSL-1 antigens induced the release of histamine but not β-hexosaminidase from unsensitized MC, suggesting a selective secretion of MC mediators. In contrast, NBL total extracts or purified NBL antigens did not induce the release of either histamine or β-hexosaminidase from MC. Interestingly, AD and ML are the stages that interact with the host during the intestinal phase of infection. The mechanisms involved in TSL-1 and AD activation of unsensitized MC may function together with other mechanisms of MC activation in host protection against T. spiralis." @default.
• W2129866684 created "2016-06-24" @default.
• W2129866684 creator A5022159359 @default.
• W2129866684 creator A5050421650 @default.
• W2129866684 creator A5050761415 @default.
• W2129866684 creator A5052315270 @default.
• W2129866684 creator A5055524253 @default.
• W2129866684 creator A5088507059 @default.
• W2129866684 creator A5091567029 @default.
• W2129866684 date "2009-02-01" @default.
• W2129866684 modified "2023-10-17" @default.
• W2129866684 title "Differential activation of mast cells by antigens from Trichinella spiralis muscle larvae, adults, and newborn larvae" @default.
• W2129866684 cites W1606162058 @default.
• W2129866684 cites W1976755134 @default.
• W2129866684 cites W1985694798 @default.
• W2129866684 cites W1996894343 @default.
• W2129866684 cites W1997280354 @default.
• W2129866684 cites W2005511031 @default.
• W2129866684 cites W2025784868 @default.
• W2129866684 cites W2028129738 @default.
• W2129866684 cites W2048464704 @default.
• W2129866684 cites W2053384227 @default.
• W2129866684 cites W2061443292 @default.
• W2129866684 cites W2065803563 @default.
• W2129866684 cites W2070975187 @default.
• W2129866684 cites W2074150277 @default.
• W2129866684 cites W2078545781 @default.
• W2129866684 cites W2084782349 @default.
• W2129866684 cites W2086923184 @default.
• W2129866684 cites W2091280513 @default.
• W2129866684 cites W2093087623 @default.
• W2129866684 cites W2113870575 @default.
• W2129866684 cites W2114089512 @default.
• W2129866684 cites W2143596626 @default.
• W2129866684 cites W2151439274 @default.
• W2129866684 cites W2158947246 @default.
• W2129866684 cites W2164117415 @default.
• W2129866684 cites W2164566194 @default.
• W2129866684 cites W2166129981 @default.
• W2129866684 doi "https://doi.org/10.1016/j.vetpar.2008.10.039" @default.
• W2129866684 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19054621" @default.
• W2129866684 hasPublicationYear "2009" @default.
• W2129866684 type Work @default.
• W2129866684 sameAs 2129866684 @default.
• W2129866684 citedByCount "13" @default.
• W2129866684 countsByYear W21298666842014 @default.
• W2129866684 countsByYear W21298666842015 @default.
• W2129866684 countsByYear W21298666842016 @default.
• W2129866684 countsByYear W21298666842017 @default.
• W2129866684 countsByYear W21298666842019 @default.
• W2129866684 countsByYear W21298666842022 @default.
• W2129866684 countsByYear W21298666842023 @default.
• W2129866684 crossrefType "journal-article" @default.
• W2129866684 hasAuthorship W2129866684A5022159359 @default.
• W2129866684 hasAuthorship W2129866684A5050421650 @default.
• W2129866684 hasAuthorship W2129866684A5050761415 @default.
• W2129866684 hasAuthorship W2129866684A5052315270 @default.
• W2129866684 hasAuthorship W2129866684A5055524253 @default.
• W2129866684 hasAuthorship W2129866684A5088507059 @default.
• W2129866684 hasAuthorship W2129866684A5091567029 @default.
• W2129866684 hasConcept C1122143 @default.
• W2129866684 hasConcept C134018914 @default.
• W2129866684 hasConcept C147483822 @default.
• W2129866684 hasConcept C153911025 @default.
• W2129866684 hasConcept C159654299 @default.
• W2129866684 hasConcept C165901193 @default.
• W2129866684 hasConcept C202751555 @default.
• W2129866684 hasConcept C203014093 @default.
• W2129866684 hasConcept C2777581317 @default.
• W2129866684 hasConcept C2779726688 @default.
• W2129866684 hasConcept C2780638806 @default.
• W2129866684 hasConcept C2781320125 @default.
• W2129866684 hasConcept C542903549 @default.
• W2129866684 hasConcept C55493867 @default.
• W2129866684 hasConcept C86803240 @default.
• W2129866684 hasConceptScore W2129866684C1122143 @default.
• W2129866684 hasConceptScore W2129866684C134018914 @default.
• W2129866684 hasConceptScore W2129866684C147483822 @default.
• W2129866684 hasConceptScore W2129866684C153911025 @default.
• W2129866684 hasConceptScore W2129866684C159654299 @default.
• W2129866684 hasConceptScore W2129866684C165901193 @default.
• W2129866684 hasConceptScore W2129866684C202751555 @default.
• W2129866684 hasConceptScore W2129866684C203014093 @default.
• W2129866684 hasConceptScore W2129866684C2777581317 @default.
• W2129866684 hasConceptScore W2129866684C2779726688 @default.
• W2129866684 hasConceptScore W2129866684C2780638806 @default.
• W2129866684 hasConceptScore W2129866684C2781320125 @default.
• W2129866684 hasConceptScore W2129866684C542903549 @default.
• W2129866684 hasConceptScore W2129866684C55493867 @default.
• W2129866684 hasConceptScore W2129866684C86803240 @default.
• W2129866684 hasIssue "3-4" @default.
• W2129866684 hasLocation W21298666841 @default.
• W2129866684 hasLocation W21298666842 @default.
• W2129866684 hasLocation W21298666843 @default.
• W2129866684 hasLocation W21298666844 @default.
• W2129866684 hasOpenAccess W2129866684 @default.
• W2129866684 hasPrimaryLocation W21298666841 @default.
• W2129866684 hasRelatedWork W152754917 @default.

• next