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• W2129941953 abstract "The levels of systemic inflammatory markers have been shown to predict future cardiovascular events, but whether they are associated with intracranial large-artery atherosclerosis is uncertain. We investigated the relation between the level of inflammatory markers interleukin-6 (IL-6) and high-sensitivity C-reactive protein (hsCRP) and subclinical intracranial large-artery atherosclerosis in patients with risk factors for atherosclerosis.Magnetic resonance angiography (MRA) was performed in 226 Japanese patients age range, 45-87 years without a history of cerebrovascular disease. Serum IL-6 and hsCRP and conventional risk factors for atherosclerosis were assessed.Forty-six patients (20.4%) were found by MRA to have one or more intracranial steno-occlusive lesions. Mean IL-6 levels were higher in patients with intracranial large-artery atherosclerosis than in those without. In addition, patients in the highest IL-6 tertile had higher unadjusted odds ratio (OR) for intracranial large-artery atherosclerosis than that of those in the lowest tertile (OR 3.25, 95% CI; 1.42-7.39). These associations were only slightly attenuated upon adjustment for conventional atherosclerotic risk factors and carotid intima-media thickness.Increased levels of IL-6 appear to be associated with intracranial large-artery disease, suggesting a role for the inflammatory process in atherosclerosis of intracranial large arteries." @default.
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• W2129941953 date "2008-03-01" @default.
• W2129941953 modified "2023-10-18" @default.
• W2129941953 title "Relation between interleukin-6 level and subclinical intracranial large-artery atherosclerosis" @default.
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• W2129941953 doi "https://doi.org/10.1016/j.atherosclerosis.2007.05.013" @default.
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