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• W2129951633 abstract "Although substantial evidence indicates that the progression of pathological changes of the neuronal cytoskeleton is crucial in determining the severity of dementia in Alzheimer's disease (AD), the exact causes and evolution of these changes, the initial site at which they begin, and the neuronal susceptibility levels for their development are poorly understood. The current clinical criteria for diagnosis of AD are focused mostly on cognitive deficits produced by dysfunction of hippocampal and high-order neocortical areas, whereas noncognitive, behavioural and psychological symptoms of dementia such as disturbances in mood, emotion, appetite, and wake-sleep cycle, confusion, agitation and depression have been less considered. The early occurrence of these symptoms suggests brainstem involvement, and more specifically of the serotonergic nuclei. In spite of the fact that the Braak and Braak staging system and National Institutes of Aging - Reagan Institute (NIA-RI) criteria do not include their evaluation, several recent reports drew attention to the possibility of selective and early involvement of raphe nuclei, particularly the dorsal raphe nucleus (DRN), in the pathogenesis of AD. Based on these findings of differential susceptibility and anatomical connectivity, a novel pathogenetic scheme of AD progression was proposed. Although the precise mechanisms of neurofibrillary degeneration still await elucidation, we speculated that cumulative oxidative damage may be the main cause of DRN alterations, as the age is the main risk factor for sporadic AD. Within such a framework, beta-amyloid production is considered only as one of the factors (although a significant one in familial cases) that promotes molecular series of events underlying AD-related neuropathological changes." @default.
• W2129951633 created "2016-06-24" @default.
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• W2129951633 creator A5074781603 @default.
• W2129951633 date "2009-11-01" @default.
• W2129951633 modified "2023-10-12" @default.
• W2129951633 title "Does Alzheimer's disease begin in the brainstem?" @default.
• W2129951633 cites W1250594259 @default.
• W2129951633 cites W1481130297 @default.
• W2129951633 cites W1487997090 @default.
• W2129951633 cites W1500435375 @default.
• W2129951633 cites W1509571186 @default.
• W2129951633 cites W1552978522 @default.
• W2129951633 cites W1553552908 @default.
• W2129951633 cites W1600934558 @default.
• W2129951633 cites W164490541 @default.
• W2129951633 cites W1765690683 @default.
• W2129951633 cites W1847168837 @default.
• W2129951633 cites W1967082239 @default.
• W2129951633 cites W1968155895 @default.
• W2129951633 cites W1971817501 @default.
• W2129951633 cites W1976452134 @default.
• W2129951633 cites W1976602187 @default.
• W2129951633 cites W1978668412 @default.
• W2129951633 cites W1981471614 @default.
• W2129951633 cites W1982064952 @default.
• W2129951633 cites W1982643751 @default.
• W2129951633 cites W1985696068 @default.
• W2129951633 cites W1985747467 @default.
• W2129951633 cites W1985802666 @default.
• W2129951633 cites W1986900475 @default.
• W2129951633 cites W1986909933 @default.
• W2129951633 cites W1987793916 @default.
• W2129951633 cites W1991886821 @default.
• W2129951633 cites W1992720458 @default.
• W2129951633 cites W1994693522 @default.
• W2129951633 cites W1995261175 @default.
• W2129951633 cites W1997417397 @default.
• W2129951633 cites W1997764398 @default.
• W2129951633 cites W2000054651 @default.
• W2129951633 cites W2000658130 @default.
• W2129951633 cites W2001704669 @default.
• W2129951633 cites W2005503435 @default.
• W2129951633 cites W2006962925 @default.
• W2129951633 cites W2007522537 @default.
• W2129951633 cites W2013884279 @default.
• W2129951633 cites W2015728316 @default.
• W2129951633 cites W2015860144 @default.
• W2129951633 cites W2017431783 @default.
• W2129951633 cites W2019628288 @default.
• W2129951633 cites W2020497815 @default.
• W2129951633 cites W2020951799 @default.
• W2129951633 cites W2023055592 @default.
• W2129951633 cites W2023586735 @default.
• W2129951633 cites W2023831571 @default.
• W2129951633 cites W2025869353 @default.
• W2129951633 cites W2026353898 @default.
• W2129951633 cites W2026589693 @default.
• W2129951633 cites W2028436804 @default.
• W2129951633 cites W2029462234 @default.
• W2129951633 cites W2031309116 @default.
• W2129951633 cites W2031654442 @default.
• W2129951633 cites W2031686950 @default.
• W2129951633 cites W2032576201 @default.
• W2129951633 cites W2035282018 @default.
• W2129951633 cites W2035339855 @default.
• W2129951633 cites W2035462700 @default.
• W2129951633 cites W2037851765 @default.
• W2129951633 cites W2039402963 @default.
• W2129951633 cites W2039765555 @default.
• W2129951633 cites W2039900537 @default.
• W2129951633 cites W2045509178 @default.
• W2129951633 cites W2046424371 @default.
• W2129951633 cites W2050454006 @default.
• W2129951633 cites W2050591554 @default.
• W2129951633 cites W2050665230 @default.
• W2129951633 cites W2051033492 @default.
• W2129951633 cites W2051218719 @default.
• W2129951633 cites W2052742260 @default.
• W2129951633 cites W2053051596 @default.
• W2129951633 cites W2053104990 @default.
• W2129951633 cites W2053116497 @default.
• W2129951633 cites W2054384828 @default.
• W2129951633 cites W2057013121 @default.
• W2129951633 cites W2057888342 @default.
• W2129951633 cites W2059501379 @default.
• W2129951633 cites W2063366627 @default.
• W2129951633 cites W2065137341 @default.
• W2129951633 cites W2066977853 @default.
• W2129951633 cites W2068376950 @default.
• W2129951633 cites W2070137740 @default.
• W2129951633 cites W2071397750 @default.
• W2129951633 cites W2073009405 @default.
• W2129951633 cites W2075061360 @default.

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