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- W2129968228 endingPage "384" @default.
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- W2129968228 abstract "Vasomotor symptoms and vaginal atrophy are both common menopausal symptoms. Hormone therapy is currently the only FDA-approved treatment for hot flashes. Current recommendations are to use the lowest dose of hormone therapy for the shortest period that will allow treatment goals to be met. Although the reanalysis of the WHI in 2007 by Roussow et al. provided evidence of coronary heart safety for users of hormone therapy under the age of 60 years and within 10 years of the onset of menopause, not all women desire or are candidates for hormone therapy. In this review we present an evidence-based discussion considering the effectiveness of hormonal and nonhormonal therapies for the relief of vasomotor symptoms and vaginal atrophy. Concern exists regarding systemic absorption of vaginal estrogen and possible adverse effects on the breast and uterus. Selective estrogen receptor modulators and estrogen agonists offer benefits through targeted estrogen agonist/antagonistic effects and are being evaluated with and without estrogen for symptomatic menopausal women. Centrally acting nonhormonal therapies that are effective for the relief of vasomotor symptoms include various antidepressants, gabapentin and clonidine. A limited number of clinical trials have been conducted with nonprescription remedies, including paced respiration, yoga, acupuncture, exercise, homeopathy and magnet therapy, and some, but not all of these, have been found to be more effective than placebo. Dietary herbal supplements, such as soy and black cohosh, have demonstrated mixed and inconclusive results in placebo-controlled trials. Potential therapies for vasomotor symptoms and vaginal atrophy require randomized, placebo-controlled trials of sufficient duration to establish efficacy and safety. Agents under investigation for vasomotor symptoms relief include neuroactive agents, such as gabapentin and desvenlafaxine; an estrogen receptor-beta-targeted herbal therapy, MF-101; and the selective estrogen receptor modulator, bazedoxifene, paired with estrogen." @default.
- W2129968228 created "2016-06-24" @default.
- W2129968228 creator A5008197953 @default.
- W2129968228 creator A5042993535 @default.
- W2129968228 creator A5074360170 @default.
- W2129968228 date "2009-07-01" @default.
- W2129968228 modified "2023-09-26" @default.
- W2129968228 title "Advances in the Treatment of Menopausal Symptoms" @default.
- W2129968228 cites W1508981734 @default.
- W2129968228 cites W1573651362 @default.
- W2129968228 cites W1586699954 @default.
- W2129968228 cites W1593442063 @default.
- W2129968228 cites W1603242223 @default.
- W2129968228 cites W1932045453 @default.
- W2129968228 cites W1944928690 @default.
- W2129968228 cites W1962138365 @default.
- W2129968228 cites W1965839232 @default.
- W2129968228 cites W1966334621 @default.
- W2129968228 cites W1971904142 @default.
- W2129968228 cites W1977154331 @default.
- W2129968228 cites W1983208188 @default.
- W2129968228 cites W1983877611 @default.
- W2129968228 cites W1985458017 @default.
- W2129968228 cites W1993327239 @default.
- W2129968228 cites W1993353686 @default.
- W2129968228 cites W1994005200 @default.
- W2129968228 cites W1994597465 @default.
- W2129968228 cites W1996328833 @default.
- W2129968228 cites W1997054444 @default.
- W2129968228 cites W1997820613 @default.
- W2129968228 cites W2003219279 @default.
- W2129968228 cites W2003863147 @default.
- W2129968228 cites W2005190075 @default.
- W2129968228 cites W2006163458 @default.
- W2129968228 cites W2006812578 @default.
- W2129968228 cites W2007059676 @default.
- W2129968228 cites W2009104120 @default.
- W2129968228 cites W2009559741 @default.
- W2129968228 cites W2009839837 @default.
- W2129968228 cites W2012846259 @default.
- W2129968228 cites W2019340572 @default.
- W2129968228 cites W2020476951 @default.
- W2129968228 cites W2021197391 @default.
- W2129968228 cites W2021974694 @default.
- W2129968228 cites W2022076582 @default.
- W2129968228 cites W2022187355 @default.
- W2129968228 cites W2022361277 @default.
- W2129968228 cites W2024733475 @default.
- W2129968228 cites W2025352687 @default.
- W2129968228 cites W2025544649 @default.
- W2129968228 cites W2026301643 @default.
- W2129968228 cites W2026579016 @default.
- W2129968228 cites W2027298599 @default.
- W2129968228 cites W2030205708 @default.
- W2129968228 cites W2030804879 @default.
- W2129968228 cites W2032187519 @default.
- W2129968228 cites W2033554091 @default.
- W2129968228 cites W2033649325 @default.
- W2129968228 cites W2034381583 @default.
- W2129968228 cites W2038276408 @default.
- W2129968228 cites W2039983851 @default.
- W2129968228 cites W2040114102 @default.
- W2129968228 cites W2040119228 @default.
- W2129968228 cites W2040371092 @default.
- W2129968228 cites W2048257551 @default.
- W2129968228 cites W2050180407 @default.
- W2129968228 cites W2051559140 @default.
- W2129968228 cites W2051879338 @default.
- W2129968228 cites W2052253052 @default.
- W2129968228 cites W2053287507 @default.
- W2129968228 cites W2054947551 @default.
- W2129968228 cites W2062258501 @default.
- W2129968228 cites W2063252233 @default.
- W2129968228 cites W2065242643 @default.
- W2129968228 cites W2066591855 @default.
- W2129968228 cites W2070125007 @default.
- W2129968228 cites W2070158101 @default.
- W2129968228 cites W2070295572 @default.
- W2129968228 cites W2075095243 @default.
- W2129968228 cites W2075237337 @default.
- W2129968228 cites W2075530771 @default.
- W2129968228 cites W2082854214 @default.
- W2129968228 cites W2084921677 @default.
- W2129968228 cites W2085008522 @default.
- W2129968228 cites W2087219606 @default.
- W2129968228 cites W2087713662 @default.
- W2129968228 cites W2087848219 @default.
- W2129968228 cites W2088926405 @default.
- W2129968228 cites W2089361437 @default.
- W2129968228 cites W2092049538 @default.
- W2129968228 cites W2092584269 @default.
- W2129968228 cites W2093444286 @default.
- W2129968228 cites W2094799558 @default.
- W2129968228 cites W2096879996 @default.
- W2129968228 cites W2100074158 @default.
- W2129968228 cites W2100328118 @default.
- W2129968228 cites W2100392631 @default.
- W2129968228 cites W2103254394 @default.