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- W2129969134 endingPage "208" @default.
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- W2129969134 abstract "Major advances in the characterization of uridine diphosphate (UDP)-glucuronosyltransferase (UGT) enzyme substrate and inhibitor selectivities and the development of experimental paradigms to investigate xenobiotic glucuronidation in vitro now permit the prediction of a range of drug-glucuronidation parameters in humans. In particular, the availability of substrate and inhibitor “probes” for the major hepatic drug metabolizing UGTs together with batteries of recombinant enzymes allow the reaction phenotyping of drug glucuronidation reactions. Additionally, in vitro experimental approaches and scaling strategies have been successfully applied to the quantitative prediction of in vivo clearance via glucuronidation and drug-drug interaction potential." @default.
- W2129969134 created "2016-06-24" @default.
- W2129969134 creator A5001047015 @default.
- W2129969134 creator A5008901409 @default.
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- W2129969134 date "2009-10-01" @default.
- W2129969134 modified "2023-09-25" @default.
- W2129969134 title "The prediction of drug-glucuronidation parameters in humans: UDP-glucuronosyltransferase enzyme-selective substrate and inhibitor probes for reaction phenotyping and<i>in vitro–in vivo</i>extrapolation of drug clearance and drug-drug interaction potential" @default.
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- W2129969134 doi "https://doi.org/10.3109/03602530903210716" @default.
- W2129969134 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19795925" @default.
- W2129969134 hasPublicationYear "2009" @default.
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