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• W2129969540 abstract "Abstract The kinetics of the permeases and beta-galactosidases of six lactose operons which had been transduced into a common genetic background from natural isolates of Escherichia coli were investigated. The fitnesses conferred by the operons were determined using chemostat competition experiments in which lactose was the sole growth-limiting factor. The cell wall is demonstrated to impose a resistance to the diffusion of galactosides at low substrate concentrations. A steady state model of the flux of lactose through the metabolic pathway (diffusion, uptake and hydrolysis) is shown to be proportional to fitness. This metabolic model is used to explain why an approximately twofold range in activity among the permease alleles confers a 13% range in fitness, whereas a similar range in activity among alleles of the beta-galactosidase confers a 0.5% range in fitness. This metabolic model implies that selection need not be maximized when a resource is scarce." @default.
• W2129969540 created "2016-06-24" @default.
• W2129969540 creator A5087169660 @default.
• W2129969540 date "1989-11-01" @default.
• W2129969540 modified "2023-09-23" @default.
• W2129969540 title "Selection and neutrality in lactose operons of Escherichia coli." @default.
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• W2129969540 doi "https://doi.org/10.1093/genetics/123.3.441" @default.
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