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• W2129977479 abstract "Abstract Aim: The aim of this study was to evaluate microalbuminuria at mid‐pregnancy, using the albumin‐to‐creatinine ratio (ACR), as a predictor of pre‐eclampsia. Material and Methods: This prospective observational study was carried out on 144 normotensive women, aged < 35 years, body mass index < 25 kg/m 2 , and live singleton pregnancy between 24 and 28 weeks. In all, the ACR was measured in spot random urine samples. Normoalbuminuria was an ACR of <30 mg/g, whereas microalbuminuria was an ACR of 30–299 mg/g creatinine. All were followed till delivery. Primary outcome was the development of pre‐eclampsia. The secondary outcome measures were preterm births and neonatal birthweight. Statistical analysis was done with Fisher's exact and t ‐tests. Results: Of all, 77.1% (111/144) had normoalbuminuria and 22.9% (33/144) had microalbuminuria. Of 33 microalbuminuric women, the mean blood pressure was significantly higher in those who subsequently developed pre‐eclampsia ( P < 0.001). The mean ACR (mg/g) in this cohort was 60.6 ± 29.4. The mean ACR (mg/g) in women who subsequently developed pre‐eclampsia was significantly higher than in women who remained normotensive ( P = 0.003). Of 33 microalbuminuric women, 12 (36.4%) developed pre‐eclampsia, and eight (24.2%) had preterm births. The mean birthweight (kg ± standard deviation) was significantly lower in the microalbuminuria group (2.45 ± 0.6) as compared to the normoalbuminuria group (2.8 ± 0.37), P < 0.001. Conclusion: Microalbuminuria in mid‐pregnancy may be a significant predictor of development of subsequent pre‐eclampsia, preterm birth and low‐birthweight babies." @default.
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• W2129977479 date "2012-08-26" @default.
• W2129977479 modified "2023-10-16" @default.
• W2129977479 title "Does microalbuminuria at mid-pregnancy predict development of subsequent pre-eclampsia?" @default.
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• W2129977479 doi "https://doi.org/10.1111/j.1447-0756.2012.01988.x" @default.
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