FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2129987233> ?p ?o ?g. }

• W2129987233 abstract "G protein-coupled receptors (GPCRs) have been shown to activate the mitogen-activated protein kinases, ERK1/2, through both G protein-dependent and -independent mechanisms. Here, we describe a G protein-independent mechanism that unravels an unanticipated role for β-arrestins. Stimulation of the V2 vasopressin receptor (V2R) in cultured cells or in vivo in rat kidney medullar collecting ducts led to the activation of ERK1/2 through the metalloproteinase-mediated shedding of a factor activating the insulin-like growth factor receptor (IGFR). This process was found to be both Src- and β-arrestin–dependent. Whereas Src was found to act upstream of the metalloproteinase activation and be required for the release of the IGFR-activating factor, β-arrestins were found to act downstream of the IGFR transactivation. Unexpectedly, the engagement of β-arrestins by the IGFR but not by the V2R was needed to promote the vasopressin-stimulated ERK1/2 activation, indicating that a pool of β-arrestins distinct from those β-arrestins recruited to the V2R acts downstream of the receptor tyrosine kinase to activate ERK1/2. Such a dual site of action for β-arrestins helps explain the pleiotropic actions of this scaffolding protein. Given the role that V2R-stimulated ERK1/2 plays in kidney cell proliferation, this transactivation mechanism may have important implications for renal pathophysiology. Still, the role of β-arrestins downstream of a transactivation event is not limited to the V2R, because we observed a similar involvement for an unrelated GPCR (the platelet-activating factor receptor), indicating that it may be a general mechanism shared among GPCRs." @default.
• W2129987233 created "2016-06-24" @default.
• W2129987233 creator A5009137313 @default.
• W2129987233 creator A5039325764 @default.
• W2129987233 creator A5050985301 @default.
• W2129987233 creator A5065132245 @default.
• W2129987233 creator A5086198173 @default.
• W2129987233 creator A5090447993 @default.
• W2129987233 date "2012-04-09" @default.
• W2129987233 modified "2023-10-03" @default.
• W2129987233 title "Engagement of β-arrestin by transactivated insulin-like growth factor receptor is needed for V2 vasopressin receptor-stimulated ERK1/2 activation" @default.
• W2129987233 cites W1521411817 @default.
• W2129987233 cites W1543291357 @default.
• W2129987233 cites W1854123316 @default.
• W2129987233 cites W1964628210 @default.
• W2129987233 cites W1965983806 @default.
• W2129987233 cites W1966834185 @default.
• W2129987233 cites W1968625794 @default.
• W2129987233 cites W1970213932 @default.
• W2129987233 cites W1972262775 @default.
• W2129987233 cites W1977234970 @default.
• W2129987233 cites W1978831789 @default.
• W2129987233 cites W1979103781 @default.
• W2129987233 cites W1979663824 @default.
• W2129987233 cites W1979741190 @default.
• W2129987233 cites W1981493299 @default.
• W2129987233 cites W1985248944 @default.
• W2129987233 cites W1985470432 @default.
• W2129987233 cites W1986137370 @default.
• W2129987233 cites W1988213013 @default.
• W2129987233 cites W1990629997 @default.
• W2129987233 cites W1990660812 @default.
• W2129987233 cites W1996273831 @default.
• W2129987233 cites W1996771419 @default.
• W2129987233 cites W1999942847 @default.
• W2129987233 cites W2001544451 @default.
• W2129987233 cites W2001626986 @default.
• W2129987233 cites W2002885378 @default.
• W2129987233 cites W2005351906 @default.
• W2129987233 cites W2006268283 @default.
• W2129987233 cites W2007852946 @default.
• W2129987233 cites W2009719824 @default.
• W2129987233 cites W2011134969 @default.
• W2129987233 cites W2012460154 @default.
• W2129987233 cites W2013895471 @default.
• W2129987233 cites W2018151362 @default.
• W2129987233 cites W2020695173 @default.
• W2129987233 cites W2022576341 @default.
• W2129987233 cites W2022847745 @default.
• W2129987233 cites W2023629636 @default.
• W2129987233 cites W2024859394 @default.
• W2129987233 cites W2032847998 @default.
• W2129987233 cites W2034967926 @default.
• W2129987233 cites W2035957263 @default.
• W2129987233 cites W2038606243 @default.
• W2129987233 cites W2042631205 @default.
• W2129987233 cites W2042693437 @default.
• W2129987233 cites W2046044139 @default.
• W2129987233 cites W2054480779 @default.
• W2129987233 cites W2056852922 @default.
• W2129987233 cites W2062401346 @default.
• W2129987233 cites W2070814481 @default.
• W2129987233 cites W2072774301 @default.
• W2129987233 cites W2074111028 @default.
• W2129987233 cites W2083334427 @default.
• W2129987233 cites W2087163465 @default.
• W2129987233 cites W2091506413 @default.
• W2129987233 cites W2117445095 @default.
• W2129987233 cites W2130632774 @default.
• W2129987233 cites W2130729770 @default.
• W2129987233 cites W2133409256 @default.
• W2129987233 cites W2134143145 @default.
• W2129987233 cites W2135453228 @default.
• W2129987233 cites W2138341116 @default.
• W2129987233 cites W2147196684 @default.
• W2129987233 cites W2149442576 @default.
• W2129987233 cites W2151312020 @default.
• W2129987233 cites W2151824014 @default.
• W2129987233 cites W2155941706 @default.
• W2129987233 cites W2156437245 @default.
• W2129987233 cites W2156753857 @default.
• W2129987233 cites W2157132367 @default.
• W2129987233 cites W2159588204 @default.
• W2129987233 cites W2160094174 @default.
• W2129987233 cites W2162841970 @default.
• W2129987233 cites W2163304919 @default.
• W2129987233 cites W4232995978 @default.
• W2129987233 doi "https://doi.org/10.1073/pnas.1112422109" @default.
• W2129987233 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3340024" @default.
• W2129987233 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22493236" @default.
• W2129987233 hasPublicationYear "2012" @default.
• W2129987233 type Work @default.
• W2129987233 sameAs 2129987233 @default.
• W2129987233 citedByCount "38" @default.
• W2129987233 countsByYear W21299872332012 @default.
• W2129987233 countsByYear W21299872332013 @default.
• W2129987233 countsByYear W21299872332014 @default.
• W2129987233 countsByYear W21299872332015 @default.
• W2129987233 countsByYear W21299872332016 @default.
• W2129987233 countsByYear W21299872332017 @default.

• next