FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2130003118> ?p ?o ?g. }

• W2130003118 endingPage "684" @default.
• W2130003118 startingPage "675" @default.
• W2130003118 abstract "Transforming growth factor-βs (TGF-β) are multifunctional proteins capable of either stimulating or inhibiting mitosis, depending on the cell type. These diverse cellular responses are caused by stimulating a single receptor complex composed of type I and type II receptors. Using a chimeric receptor model where the granulocyte/monocyte colony-stimulating factor receptor ligand binding domains are fused to the transmembrane and cytoplasmic signaling domains of the TGF-β type I and II receptors, we wished to describe the role(s) of specific amino acid residues in regulating ligand-mediated endocytosis and signaling in fibroblasts and epithelial cells. Specific point mutations were introduced at Y182, T200, and Y249 of the type I receptor and K277 and P525 of the type II receptor. Mutation of either Y182 or Y249, residues within two putative consensus tyrosine-based internalization motifs, had no effect on endocytosis or signaling. This is in contrast to mutation of T200 to valine, which resulted in ablation of signaling in both cell types, while only abolishing receptor down-regulation in fibroblasts. Moreover, in the absence of ligand, both fibroblasts and epithelial cells constitutively internalize and recycle the TGF-β receptor complex back to the plasma membrane. The data indicate fundamental differences between mesenchymal and epithelial cells in endocytic sorting and suggest that ligand binding diverts heteromeric receptors from the default recycling pool to a pathway mediating receptor down-regulation and signaling." @default.
• W2130003118 created "2016-06-24" @default.
• W2130003118 creator A5023899114 @default.
• W2130003118 creator A5032090136 @default.
• W2130003118 creator A5049115505 @default.
• W2130003118 creator A5070147587 @default.
• W2130003118 creator A5073418646 @default.
• W2130003118 creator A5074767002 @default.
• W2130003118 date "2001-03-01" @default.
• W2130003118 modified "2023-09-26" @default.
• W2130003118 title "Mechanisms of Transforming Growth Factor-β Receptor Endocytosis and Intracellular Sorting Differ between Fibroblasts and Epithelial Cells" @default.
• W2130003118 cites W1487627529 @default.
• W2130003118 cites W1494055834 @default.
• W2130003118 cites W1523743194 @default.
• W2130003118 cites W1546723684 @default.
• W2130003118 cites W1566041190 @default.
• W2130003118 cites W157700276 @default.
• W2130003118 cites W1605821595 @default.
• W2130003118 cites W1663371441 @default.
• W2130003118 cites W1677719282 @default.
• W2130003118 cites W1858586091 @default.
• W2130003118 cites W1914274337 @default.
• W2130003118 cites W1972819616 @default.
• W2130003118 cites W1979178399 @default.
• W2130003118 cites W1979815209 @default.
• W2130003118 cites W1991203655 @default.
• W2130003118 cites W1993154317 @default.
• W2130003118 cites W1997966048 @default.
• W2130003118 cites W1998725105 @default.
• W2130003118 cites W1999281989 @default.
• W2130003118 cites W2006509046 @default.
• W2130003118 cites W2020328367 @default.
• W2130003118 cites W2021263701 @default.
• W2130003118 cites W2024296876 @default.
• W2130003118 cites W2049652225 @default.
• W2130003118 cites W2063181556 @default.
• W2130003118 cites W2070470162 @default.
• W2130003118 cites W2073286199 @default.
• W2130003118 cites W2078774618 @default.
• W2130003118 cites W2080569490 @default.
• W2130003118 cites W2081248251 @default.
• W2130003118 cites W2101849511 @default.
• W2130003118 cites W2103031848 @default.
• W2130003118 cites W2125457600 @default.
• W2130003118 cites W2134344512 @default.
• W2130003118 cites W2140194302 @default.
• W2130003118 cites W2142498139 @default.
• W2130003118 cites W2144464927 @default.
• W2130003118 cites W2155828042 @default.
• W2130003118 cites W2156126895 @default.
• W2130003118 cites W2164279207 @default.
• W2130003118 cites W2168995491 @default.
• W2130003118 cites W2178812731 @default.
• W2130003118 cites W2472870113 @default.
• W2130003118 cites W4231136244 @default.
• W2130003118 cites W84752278 @default.
• W2130003118 doi "https://doi.org/10.1091/mbc.12.3.675" @default.
• W2130003118 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/30972" @default.
• W2130003118 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11251079" @default.
• W2130003118 hasPublicationYear "2001" @default.
• W2130003118 type Work @default.
• W2130003118 sameAs 2130003118 @default.
• W2130003118 citedByCount "53" @default.
• W2130003118 countsByYear W21300031182012 @default.
• W2130003118 countsByYear W21300031182013 @default.
• W2130003118 countsByYear W21300031182014 @default.
• W2130003118 countsByYear W21300031182015 @default.
• W2130003118 countsByYear W21300031182016 @default.
• W2130003118 countsByYear W21300031182017 @default.
• W2130003118 countsByYear W21300031182018 @default.
• W2130003118 countsByYear W21300031182019 @default.
• W2130003118 countsByYear W21300031182020 @default.
• W2130003118 countsByYear W21300031182021 @default.
• W2130003118 countsByYear W21300031182022 @default.
• W2130003118 countsByYear W21300031182023 @default.
• W2130003118 crossrefType "journal-article" @default.
• W2130003118 hasAuthorship W2130003118A5023899114 @default.
• W2130003118 hasAuthorship W2130003118A5032090136 @default.
• W2130003118 hasAuthorship W2130003118A5049115505 @default.
• W2130003118 hasAuthorship W2130003118A5070147587 @default.
• W2130003118 hasAuthorship W2130003118A5073418646 @default.
• W2130003118 hasAuthorship W2130003118A5074767002 @default.
• W2130003118 hasBestOaLocation W21300031182 @default.
• W2130003118 hasConcept C101544691 @default.
• W2130003118 hasConcept C139770010 @default.
• W2130003118 hasConcept C170493617 @default.
• W2130003118 hasConcept C28005876 @default.
• W2130003118 hasConcept C55493867 @default.
• W2130003118 hasConcept C62478195 @default.
• W2130003118 hasConcept C79747257 @default.
• W2130003118 hasConcept C86803240 @default.
• W2130003118 hasConcept C95444343 @default.
• W2130003118 hasConceptScore W2130003118C101544691 @default.
• W2130003118 hasConceptScore W2130003118C139770010 @default.
• W2130003118 hasConceptScore W2130003118C170493617 @default.
• W2130003118 hasConceptScore W2130003118C28005876 @default.
• W2130003118 hasConceptScore W2130003118C55493867 @default.
• W2130003118 hasConceptScore W2130003118C62478195 @default.

• next