Matches in SemOpenAlex for { <https://semopenalex.org/work/W2130003670> ?p ?o ?g. }
- W2130003670 endingPage "818" @default.
- W2130003670 startingPage "801" @default.
- W2130003670 abstract "Statins are used to control elevated cholesterol or hypercholesterolemia, but have previously been reported to have antiviral properties. Aims: To show efficacy of statins in various influenza virus mouse models. Materials & methods: BALB/c mice were treated intraperitoneally or orally with several types of statins (simvastatin, lovastatin, mevastatin, pitavastatin, atorvastatin or rosuvastatin) at various concentrations before or after infection with either influenza A/Duck/MN/1525/81 H5N1 virus, influenza A/Vietnam/1203/2004 H5N1 virus, influenza A/Victoria/3/75 H3N2 virus, influenza A/NWS/33 H1N1 virus or influenza A/CA/04/09 H1N1pdm09 virus. Results: The statins administered intraperitoneally or orally at any dose did not significantly enhance the total survivors relative to untreated controls. In addition, infected mice receiving any concentration of statin were not protected against weight loss due to the infection. None of the statins significantly increased the mean day of death relative to mice in the placebo treatment group. Furthermore, the statins had relatively few ameliorative effects on lung pathology or lung weights at day 3 and 6 after virus exposure, although mice treated with simvastatin did have improved lung function as measured by arterial saturated oxygen levels in one experiment. Conclusion: Statins showed relatively little efficacy in any mouse model used by any parameter tested." @default.
- W2130003670 created "2016-06-24" @default.
- W2130003670 creator A5030937108 @default.
- W2130003670 creator A5062162666 @default.
- W2130003670 creator A5068456155 @default.
- W2130003670 date "2012-08-01" @default.
- W2130003670 modified "2023-09-23" @default.
- W2130003670 title "Effect of statin treatments on highly pathogenic avian influenza H5N1, seasonal and H1N1pdm09 virus infections in BALB/c mice" @default.
- W2130003670 cites W1502204933 @default.
- W2130003670 cites W1523679951 @default.
- W2130003670 cites W1546765124 @default.
- W2130003670 cites W1963547303 @default.
- W2130003670 cites W1964250840 @default.
- W2130003670 cites W1972004366 @default.
- W2130003670 cites W1977142289 @default.
- W2130003670 cites W1980283008 @default.
- W2130003670 cites W1980801167 @default.
- W2130003670 cites W1987316497 @default.
- W2130003670 cites W1995859934 @default.
- W2130003670 cites W2012929392 @default.
- W2130003670 cites W2013789691 @default.
- W2130003670 cites W2030510738 @default.
- W2130003670 cites W2034412658 @default.
- W2130003670 cites W2039307660 @default.
- W2130003670 cites W2045772779 @default.
- W2130003670 cites W2047815636 @default.
- W2130003670 cites W2051761287 @default.
- W2130003670 cites W2052287941 @default.
- W2130003670 cites W2053856289 @default.
- W2130003670 cites W2054301006 @default.
- W2130003670 cites W2054537683 @default.
- W2130003670 cites W2055115226 @default.
- W2130003670 cites W2064622635 @default.
- W2130003670 cites W2067474072 @default.
- W2130003670 cites W2073654433 @default.
- W2130003670 cites W2075071264 @default.
- W2130003670 cites W2080333902 @default.
- W2130003670 cites W2081141733 @default.
- W2130003670 cites W2082220063 @default.
- W2130003670 cites W2082601653 @default.
- W2130003670 cites W2086214991 @default.
- W2130003670 cites W2092284960 @default.
- W2130003670 cites W2098349861 @default.
- W2130003670 cites W2102368840 @default.
- W2130003670 cites W2104178698 @default.
- W2130003670 cites W2105278533 @default.
- W2130003670 cites W2105740113 @default.
- W2130003670 cites W2106234764 @default.
- W2130003670 cites W2108367829 @default.
- W2130003670 cites W2112672809 @default.
- W2130003670 cites W2113038532 @default.
- W2130003670 cites W2113968522 @default.
- W2130003670 cites W2119577364 @default.
- W2130003670 cites W2121202591 @default.
- W2130003670 cites W2122879546 @default.
- W2130003670 cites W2126078732 @default.
- W2130003670 cites W2127278205 @default.
- W2130003670 cites W2129239355 @default.
- W2130003670 cites W2130027755 @default.
- W2130003670 cites W2132867392 @default.
- W2130003670 cites W2136685402 @default.
- W2130003670 cites W2137053070 @default.
- W2130003670 cites W2137293763 @default.
- W2130003670 cites W2149533101 @default.
- W2130003670 cites W2152165117 @default.
- W2130003670 cites W2153568159 @default.
- W2130003670 cites W2154059493 @default.
- W2130003670 cites W2154634584 @default.
- W2130003670 cites W2156140162 @default.
- W2130003670 cites W2156506016 @default.
- W2130003670 cites W2166036680 @default.
- W2130003670 cites W2167027103 @default.
- W2130003670 cites W2167264893 @default.
- W2130003670 cites W2170434427 @default.
- W2130003670 cites W2171064899 @default.
- W2130003670 cites W2261721173 @default.
- W2130003670 doi "https://doi.org/10.2217/fvl.12.71" @default.
- W2130003670 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3571729" @default.
- W2130003670 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23420457" @default.
- W2130003670 hasPublicationYear "2012" @default.
- W2130003670 type Work @default.
- W2130003670 sameAs 2130003670 @default.
- W2130003670 citedByCount "25" @default.
- W2130003670 countsByYear W21300036702013 @default.
- W2130003670 countsByYear W21300036702014 @default.
- W2130003670 countsByYear W21300036702016 @default.
- W2130003670 countsByYear W21300036702017 @default.
- W2130003670 countsByYear W21300036702018 @default.
- W2130003670 countsByYear W21300036702019 @default.
- W2130003670 countsByYear W21300036702020 @default.
- W2130003670 countsByYear W21300036702021 @default.
- W2130003670 countsByYear W21300036702022 @default.
- W2130003670 crossrefType "journal-article" @default.
- W2130003670 hasAuthorship W2130003670A5030937108 @default.
- W2130003670 hasAuthorship W2130003670A5062162666 @default.
- W2130003670 hasAuthorship W2130003670A5068456155 @default.
- W2130003670 hasBestOaLocation W21300036702 @default.
- W2130003670 hasConcept C126322002 @default.