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- W2130018092 abstract "Significance Major depressive disorder is a significant contributor to the global burden of disease, affecting 350 million people according to an estimation of the World Health Organization. Today, no valid biomarkers of depression, which could predict the efficacy of a certain treatment in a certain group of patients, exist. Sleep deprivation is an effective and rapid-acting antidepressive treatment. However, the biomechanism of this effect is largely unknown. This study shows the effects of sleep deprivation on human brain functional connectivity alterations via the dorsal nexus, an area which is crucial in major depressive disorder. Here, we offer a neurobiological explanation for the known antidepressive action of sleep deprivation." @default.
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- W2130018092 date "2013-11-11" @default.
- W2130018092 modified "2023-09-29" @default.
- W2130018092 title "Sleep deprivation increases dorsal nexus connectivity to the dorsolateral prefrontal cortex in humans" @default.
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- W2130018092 doi "https://doi.org/10.1073/pnas.1317010110" @default.
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