FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2130026861> ?p ?o ?g. }

• W2130026861 endingPage "1857" @default.
• W2130026861 startingPage "1849" @default.
• W2130026861 abstract "Evidence indicates that cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) may negatively regulate T cell activation, but the basis for the inhibitory effect remains unknown. We report here that cross-linking of CTLA-4 induces transforming growth factor beta (TGF-beta) production by murine CD4(+) T cells. CD4(+) T helper type 1 (Th1), Th2, and Th0 clones all secrete TGF-beta after antibody cross-linking of CTLA-4, indicating that induction of TGF-beta by CTLA-4 signaling represents a ubiquitous feature of murine CD4(+) T cells. Stimulation of the CD3-T cell antigen receptor complex does not independently induce TGF-beta, but is required for optimal CTLA-4-mediated TGF-beta production. The consequences of cross-linking of CTLA-4, together with CD3 and CD28, include inhibition of T cell proliferation and interleukin (IL)-2 secretion, as well as suppression of both interferon gamma (Th1) and IL-4 (Th2). Moreover, addition of anti-TGF-beta partially reverses this T cell suppression. When CTLA-4 was cross-linked in T cell populations from TGF-beta1 gene-deleted (TGF-beta1(-/-)) mice, the T cell responses were only suppressed 38% compared with 95% in wild-type mice. Our data demonstrate that engagement of CTLA-4 leads to CD4(+) T cell production of TGF-beta, which, in part, contributes to the downregulation of T cell activation. CTLA-4, through TGF-beta, may serve as a counterbalance for CD28 costimulation of IL-2 and CD4(+) T cell activation." @default.
• W2130026861 created "2016-06-24" @default.
• W2130026861 creator A5032884063 @default.
• W2130026861 creator A5035673687 @default.
• W2130026861 creator A5044271761 @default.
• W2130026861 date "1998-11-16" @default.
• W2130026861 modified "2023-10-13" @default.
• W2130026861 title "Engagement of Cytotoxic T Lymphocyte–associated Antigen 4 (CTLA-4) Induces Transforming Growth Factor β (TGF-β) Production by Murine CD4+ T Cells" @default.
• W2130026861 cites W1499556315 @default.
• W2130026861 cites W1517570604 @default.
• W2130026861 cites W1528584436 @default.
• W2130026861 cites W1533770469 @default.
• W2130026861 cites W1541589221 @default.
• W2130026861 cites W1547565061 @default.
• W2130026861 cites W1549555023 @default.
• W2130026861 cites W1618611363 @default.
• W2130026861 cites W1681118831 @default.
• W2130026861 cites W1845038035 @default.
• W2130026861 cites W1886267442 @default.
• W2130026861 cites W1906640112 @default.
• W2130026861 cites W1974381902 @default.
• W2130026861 cites W1978373343 @default.
• W2130026861 cites W1988317772 @default.
• W2130026861 cites W2003907692 @default.
• W2130026861 cites W2015085911 @default.
• W2130026861 cites W2019976074 @default.
• W2130026861 cites W2025806580 @default.
• W2130026861 cites W2029060163 @default.
• W2130026861 cites W2042527277 @default.
• W2130026861 cites W2044069347 @default.
• W2130026861 cites W2045008512 @default.
• W2130026861 cites W2045887180 @default.
• W2130026861 cites W2048073154 @default.
• W2130026861 cites W2051090019 @default.
• W2130026861 cites W2051502229 @default.
• W2130026861 cites W2053092986 @default.
• W2130026861 cites W2058006748 @default.
• W2130026861 cites W2058585600 @default.
• W2130026861 cites W2070470162 @default.
• W2130026861 cites W2072324037 @default.
• W2130026861 cites W2076067786 @default.
• W2130026861 cites W2079140747 @default.
• W2130026861 cites W2079517510 @default.
• W2130026861 cites W2084544247 @default.
• W2130026861 cites W2085419002 @default.
• W2130026861 cites W2087792479 @default.
• W2130026861 cites W2094366129 @default.
• W2130026861 cites W2109509860 @default.
• W2130026861 cites W2109556041 @default.
• W2130026861 cites W2114329158 @default.
• W2130026861 cites W2115129190 @default.
• W2130026861 cites W2118857294 @default.
• W2130026861 cites W2119512066 @default.
• W2130026861 cites W2136797684 @default.
• W2130026861 cites W2136819827 @default.
• W2130026861 cites W2154055388 @default.
• W2130026861 cites W2162466652 @default.
• W2130026861 cites W2162856391 @default.
• W2130026861 cites W2164903177 @default.
• W2130026861 cites W2441700042 @default.
• W2130026861 cites W4313343488 @default.
• W2130026861 doi "https://doi.org/10.1084/jem.188.10.1849" @default.
• W2130026861 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2212416" @default.
• W2130026861 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9815262" @default.
• W2130026861 hasPublicationYear "1998" @default.
• W2130026861 type Work @default.
• W2130026861 sameAs 2130026861 @default.
• W2130026861 citedByCount "345" @default.
• W2130026861 countsByYear W21300268612012 @default.
• W2130026861 countsByYear W21300268612013 @default.
• W2130026861 countsByYear W21300268612014 @default.
• W2130026861 countsByYear W21300268612015 @default.
• W2130026861 countsByYear W21300268612016 @default.
• W2130026861 countsByYear W21300268612017 @default.
• W2130026861 countsByYear W21300268612018 @default.
• W2130026861 countsByYear W21300268612019 @default.
• W2130026861 countsByYear W21300268612020 @default.
• W2130026861 countsByYear W21300268612021 @default.
• W2130026861 countsByYear W21300268612022 @default.
• W2130026861 countsByYear W21300268612023 @default.
• W2130026861 crossrefType "journal-article" @default.
• W2130026861 hasAuthorship W2130026861A5032884063 @default.
• W2130026861 hasAuthorship W2130026861A5035673687 @default.
• W2130026861 hasAuthorship W2130026861A5044271761 @default.
• W2130026861 hasBestOaLocation W21300268611 @default.
• W2130026861 hasConcept C118131993 @default.
• W2130026861 hasConcept C147483822 @default.
• W2130026861 hasConcept C148125776 @default.
• W2130026861 hasConcept C153911025 @default.
• W2130026861 hasConcept C154317977 @default.
• W2130026861 hasConcept C167672396 @default.
• W2130026861 hasConcept C202751555 @default.
• W2130026861 hasConcept C203014093 @default.
• W2130026861 hasConcept C21705690 @default.
• W2130026861 hasConcept C2776090121 @default.
• W2130026861 hasConcept C2778229498 @default.
• W2130026861 hasConcept C55493867 @default.
• W2130026861 hasConcept C86803240 @default.

• next