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- W2130031520 endingPage "905" @default.
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- W2130031520 abstract "Regenerative treatment of dilated, non-ischaemic cardiomyopathy represents a significant unmet clinical need. Intracoronary administration of autologous bone marrow stem cells has demonstrated positive results in treatment of post-infarct and chronic ischaemic patients. Limitations of this procedure include: invasiveness of bone marrow extraction and cardiac catheterization, and dependence on stem cell populations that are aged and possibly senescent. Here, the use of intravenously administered allogeneic placental matrix derived mesenchymal stem cells for treatment of dilated cardiomyopathy is discussed. Safety of this cell population has already been established in completed Phase I and II trials; however, to date, clinical implementation for dilated cardiomyopathy has not been reported. Preclinical studies have demonstrated that mesenchymal stem cells: (i) inhibit myocardial inflammation; (ii) inhibit cardiomyocyte apoptosis; (iii) stimulate angiogenesis; and (iv) display therapeutic activity in models of dilated cardiomyopathy. Clinical studies have demonstrated the ability of mesenchymal stem cells to inhibit post-infarct remodelling, as well as potently block inflammatory processes in graft versus host and Crohn disease. Presented here is case report of a patient with dilated cardiomyopathy treated with intravenous allogeneic mesenchymal stem cells and expanded umbilical cord blood CD34 cells who underwent a profound clinical improvement." @default.
- W2130031520 created "2016-06-24" @default.
- W2130031520 creator A5003489337 @default.
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- W2130031520 creator A5067750165 @default.
- W2130031520 creator A5072188865 @default.
- W2130031520 creator A5089883823 @default.
- W2130031520 date "2008-01-01" @default.
- W2130031520 modified "2023-10-01" @default.
- W2130031520 title "Placental mesenchymal and cord blood stem cell therapy for dilated cardiomyopathy" @default.
- W2130031520 cites W1489130191 @default.
- W2130031520 cites W1631250427 @default.
- W2130031520 cites W1781491504 @default.
- W2130031520 cites W1923684395 @default.
- W2130031520 cites W1964058577 @default.
- W2130031520 cites W1966733849 @default.
- W2130031520 cites W1970344859 @default.
- W2130031520 cites W1970617808 @default.
- W2130031520 cites W1977872287 @default.
- W2130031520 cites W1980153680 @default.
- W2130031520 cites W1982657650 @default.
- W2130031520 cites W1986547199 @default.
- W2130031520 cites W1990927228 @default.
- W2130031520 cites W1994407421 @default.
- W2130031520 cites W1995284580 @default.
- W2130031520 cites W1997470313 @default.
- W2130031520 cites W1997674744 @default.
- W2130031520 cites W1998053882 @default.
- W2130031520 cites W1998476642 @default.
- W2130031520 cites W2000068994 @default.
- W2130031520 cites W2000536297 @default.
- W2130031520 cites W2005742284 @default.
- W2130031520 cites W2006601515 @default.
- W2130031520 cites W2010507176 @default.
- W2130031520 cites W2011710975 @default.
- W2130031520 cites W2021224652 @default.
- W2130031520 cites W2023760272 @default.
- W2130031520 cites W2033945370 @default.
- W2130031520 cites W2035040935 @default.
- W2130031520 cites W2035547684 @default.
- W2130031520 cites W2035603724 @default.
- W2130031520 cites W2036348189 @default.
- W2130031520 cites W2039373683 @default.
- W2130031520 cites W2041570457 @default.
- W2130031520 cites W2044674062 @default.
- W2130031520 cites W2045382887 @default.
- W2130031520 cites W2046785625 @default.
- W2130031520 cites W2050744280 @default.
- W2130031520 cites W2056298308 @default.
- W2130031520 cites W2056806365 @default.
- W2130031520 cites W2060114255 @default.
- W2130031520 cites W2063311461 @default.
- W2130031520 cites W2066092834 @default.
- W2130031520 cites W2071407810 @default.
- W2130031520 cites W2071746224 @default.
- W2130031520 cites W2073084279 @default.
- W2130031520 cites W2074994532 @default.
- W2130031520 cites W2075377709 @default.
- W2130031520 cites W2075639684 @default.
- W2130031520 cites W2084273906 @default.
- W2130031520 cites W2086268876 @default.
- W2130031520 cites W2087041770 @default.
- W2130031520 cites W2088606576 @default.
- W2130031520 cites W2090068113 @default.
- W2130031520 cites W2094654459 @default.
- W2130031520 cites W2099633666 @default.
- W2130031520 cites W2101490763 @default.
- W2130031520 cites W2106117542 @default.
- W2130031520 cites W2106673834 @default.
- W2130031520 cites W2106697674 @default.
- W2130031520 cites W2107111991 @default.
- W2130031520 cites W2107524856 @default.
- W2130031520 cites W2110667326 @default.
- W2130031520 cites W2111267459 @default.
- W2130031520 cites W2113551024 @default.
- W2130031520 cites W2117591594 @default.
- W2130031520 cites W2117766903 @default.
- W2130031520 cites W2123049040 @default.
- W2130031520 cites W2123163588 @default.
- W2130031520 cites W2125417661 @default.
- W2130031520 cites W2129574297 @default.
- W2130031520 cites W2130520407 @default.
- W2130031520 cites W2135358140 @default.
- W2130031520 cites W2139234903 @default.
- W2130031520 cites W2139424224 @default.
- W2130031520 cites W2142216180 @default.
- W2130031520 cites W2150437477 @default.
- W2130031520 cites W2151722542 @default.
- W2130031520 cites W2154937731 @default.
- W2130031520 cites W2158401423 @default.
- W2130031520 cites W2158682140 @default.
- W2130031520 cites W2162484388 @default.
- W2130031520 cites W2164506013 @default.
- W2130031520 cites W2166000466 @default.
- W2130031520 cites W2166993110 @default.
- W2130031520 cites W2173231961 @default.