FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2130043659> ?p ?o ?g. }

• W2130043659 endingPage "159" @default.
• W2130043659 startingPage "153" @default.
• W2130043659 abstract "Cushing's disease appears as a functionally heterogeneous disease, but criteria that are able to distinguish between different clinical forms remain elusive. We compared two subgroups of patients with proven Cushing's disease according to the size of the pituitary adenoma, evaluated by computed tomography or magnetic resonance imaging. Our series comprised 11 patients with a microadenoma and 10 with a macroadenoma (median volumes (range): 173 (13-270) and 3022 (500-10312) mm3 respectively; P < 0.0001). The clinical presentation was similar in the two groups, but the time elapsed before diagnosis was longer, and visual impairment was less frequent in the patients with a microadenoma (1.5+/-0.8 years and 0%) than in those with a macroadenoma (0.7+/-0.6 years and 40%; P < 0.05). Morning and evening peripheral concentrations of ACTH were greater in patients with macroadenoma (134+/-78 and 130+/-7 ng/l respectively) than in those with microadenoma (52+/-28 and 56+/-19 ng/l, P < 0.05). Hypokalaemia and lymphopenia were also more pronounced in patients with macroadenoma (3.4+/-0.3 mmol/l and 1273+/-401 lymphocytes/mm3) than in those with microadenoma (3.8+/-0.3 mmol/l and 1852+/-668 lymphocytes/mm3 P < 0.05), although morning and evening plasma cortisol concentrations were similar in both groups. In patients with macroadenoma, there was less relative nycthemeral variation of ACTH concentrations (28+/-24%, compared with 62+/-39% in those with microadenoma; P < 0.05), less suppression of plasma cortisol by high doses of dexamethasone (-30+/-14%, compared with -61+/-25%; P < 0.05), and a reduced concentration ratio of mean basal cortisol to ACTH (7+/-3, compared with 12+/-5; P < 0.05). Plasma IGF-I concentration and the TSH peak response to TRH were significantly lower in patients with macroadenoma than in those with microadenoma (0.4+/-0.2 x 10(3) IU/I and 2.3+/-1.8 mIU/I, compared with 1.8+/-0.6 x 10(3) IU/I and 5.2+/-1.6 mUI/l; P < 0.05). Thus, in comparison with microadenomas, corticotroph macroadenomas are characterized by a greater and more autonomous ACTH secretion, inducing more pronounced biological signs of hypercorticism, and are more often accompanied by visual field defects and impairment of other pituitary hormonal secretions." @default.
• W2130043659 created "2016-06-24" @default.
• W2130043659 creator A5030821450 @default.
• W2130043659 creator A5033181736 @default.
• W2130043659 creator A5040224467 @default.
• W2130043659 creator A5076638023 @default.
• W2130043659 date "1998-02-01" @default.
• W2130043659 modified "2023-10-15" @default.
• W2130043659 title "Cushing's disease: a comparison of pituitary corticotroph microadenomas and macroadenomas" @default.
• W2130043659 cites W1966184376 @default.
• W2130043659 cites W1992786401 @default.
• W2130043659 cites W2003264288 @default.
• W2130043659 cites W2004859554 @default.
• W2130043659 cites W2010744138 @default.
• W2130043659 cites W2015989748 @default.
• W2130043659 cites W2018299169 @default.
• W2130043659 cites W2019588074 @default.
• W2130043659 cites W2031835256 @default.
• W2130043659 cites W2063155886 @default.
• W2130043659 cites W2082382521 @default.
• W2130043659 cites W2133256820 @default.
• W2130043659 cites W2137186207 @default.
• W2130043659 cites W2142384795 @default.
• W2130043659 cites W2152849156 @default.
• W2130043659 cites W2308521615 @default.
• W2130043659 cites W2317352701 @default.
• W2130043659 cites W2399751888 @default.
• W2130043659 cites W2409459951 @default.
• W2130043659 doi "https://doi.org/10.1530/eje.0.1380153" @default.
• W2130043659 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9506858" @default.
• W2130043659 hasPublicationYear "1998" @default.
• W2130043659 type Work @default.
• W2130043659 sameAs 2130043659 @default.
• W2130043659 citedByCount "45" @default.
• W2130043659 countsByYear W21300436592012 @default.
• W2130043659 countsByYear W21300436592013 @default.
• W2130043659 countsByYear W21300436592014 @default.
• W2130043659 countsByYear W21300436592015 @default.
• W2130043659 countsByYear W21300436592016 @default.
• W2130043659 countsByYear W21300436592018 @default.
• W2130043659 countsByYear W21300436592019 @default.
• W2130043659 countsByYear W21300436592020 @default.
• W2130043659 countsByYear W21300436592021 @default.
• W2130043659 countsByYear W21300436592022 @default.
• W2130043659 crossrefType "journal-article" @default.
• W2130043659 hasAuthorship W2130043659A5030821450 @default.
• W2130043659 hasAuthorship W2130043659A5033181736 @default.
• W2130043659 hasAuthorship W2130043659A5040224467 @default.
• W2130043659 hasAuthorship W2130043659A5076638023 @default.
• W2130043659 hasBestOaLocation W21300436591 @default.
• W2130043659 hasConcept C121332964 @default.
• W2130043659 hasConcept C126322002 @default.
• W2130043659 hasConcept C126838900 @default.
• W2130043659 hasConcept C1276947 @default.
• W2130043659 hasConcept C134018914 @default.
• W2130043659 hasConcept C143409427 @default.
• W2130043659 hasConcept C19720800 @default.
• W2130043659 hasConcept C2776476923 @default.
• W2130043659 hasConcept C2776810848 @default.
• W2130043659 hasConcept C2777428134 @default.
• W2130043659 hasConcept C2777658017 @default.
• W2130043659 hasConcept C2779134260 @default.
• W2130043659 hasConcept C2779318953 @default.
• W2130043659 hasConcept C71315377 @default.
• W2130043659 hasConcept C71924100 @default.
• W2130043659 hasConcept C79381400 @default.
• W2130043659 hasConceptScore W2130043659C121332964 @default.
• W2130043659 hasConceptScore W2130043659C126322002 @default.
• W2130043659 hasConceptScore W2130043659C126838900 @default.
• W2130043659 hasConceptScore W2130043659C1276947 @default.
• W2130043659 hasConceptScore W2130043659C134018914 @default.
• W2130043659 hasConceptScore W2130043659C143409427 @default.
• W2130043659 hasConceptScore W2130043659C19720800 @default.
• W2130043659 hasConceptScore W2130043659C2776476923 @default.
• W2130043659 hasConceptScore W2130043659C2776810848 @default.
• W2130043659 hasConceptScore W2130043659C2777428134 @default.
• W2130043659 hasConceptScore W2130043659C2777658017 @default.
• W2130043659 hasConceptScore W2130043659C2779134260 @default.
• W2130043659 hasConceptScore W2130043659C2779318953 @default.
• W2130043659 hasConceptScore W2130043659C71315377 @default.
• W2130043659 hasConceptScore W2130043659C71924100 @default.
• W2130043659 hasConceptScore W2130043659C79381400 @default.
• W2130043659 hasLocation W21300436591 @default.
• W2130043659 hasLocation W21300436592 @default.
• W2130043659 hasLocation W21300436593 @default.
• W2130043659 hasOpenAccess W2130043659 @default.
• W2130043659 hasPrimaryLocation W21300436591 @default.
• W2130043659 hasRelatedWork W2022069463 @default.
• W2130043659 hasRelatedWork W2069951324 @default.
• W2130043659 hasRelatedWork W2168950058 @default.
• W2130043659 hasRelatedWork W2282906446 @default.
• W2130043659 hasRelatedWork W2377049009 @default.
• W2130043659 hasRelatedWork W3093233262 @default.
• W2130043659 hasRelatedWork W3154528136 @default.
• W2130043659 hasRelatedWork W4282912787 @default.
• W2130043659 hasRelatedWork W4304782129 @default.
• W2130043659 hasRelatedWork W575907984 @default.
• W2130043659 isParatext "false" @default.

• next