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• W2130048277 endingPage "4647" @default.
• W2130048277 startingPage "4636" @default.
• W2130048277 abstract "The Golgi P-type Ca2+-ATPase, Pmr1p, is the major player for calcium homeostasis in yeast. The inactivation of KlPMR1 in Kluyveromyces lactis leads to high pleiotropic phenotypes that include reduced glycosylation, cell wall defects, and alterations of mitochondrial metabolism. In this article we found that cells lacking KlPmr1p have a morphologically altered mitochondrial network and that mitochondria (m) from Klpmr1delta cells accumulate Ca2+ more slowly and reach a lower [Ca2+]m level, when exposed to [Ca2+] < 5 microM, than wild-type cells. The Klpmr1delta cells also exhibit traits of ongoing oxidative stress and present hyperphosphorylation of KlHog1p, the hallmark for the activation of stress response pathways. The mitochondrial chaperone KlHsp60 acts as a multicopy suppressor of phenotypes that occur in cells lacking the Ca2+-ATPase, including relief from oxidative stress and recovery of cell wall thickness and functionality. Inhibition of KlPMR1 function decreases KlHSP60 expression at both mRNA and protein levels. Moreover, KlPRM1 loss of function correlates with both decreases in HSF DNA binding activity and KlHSP60 expression. We suggest a role for KlPMR1 in HSF DNA binding activity, which is required for proper KlHSP60 expression, a key step in oxidative stress response." @default.
• W2130048277 created "2016-06-24" @default.
• W2130048277 creator A5007148368 @default.
• W2130048277 creator A5012369463 @default.
• W2130048277 creator A5017985509 @default.
• W2130048277 creator A5027748782 @default.
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• W2130048277 creator A5078466205 @default.
• W2130048277 creator A5082531446 @default.
• W2130048277 creator A5087990867 @default.
• W2130048277 date "2005-10-01" @default.
• W2130048277 modified "2023-09-25" @default.
• W2130048277 title "The Golgi Ca²⁺-ATPase KlPmr1p Function Is Required for Oxidative Stress Response by Controlling the Expression of the Heat-Shock Element<i>HSP60</i>in<i>Kluyveromyces lactis</i>" @default.
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• W2130048277 doi "https://doi.org/10.1091/mbc.e05-02-0138" @default.
• W2130048277 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1237070" @default.
• W2130048277 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16030259" @default.
• W2130048277 hasPublicationYear "2005" @default.
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