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• W2130063893 abstract "ObjectiveSeveral phthalates are reproductive toxicants in animals and human occupational exposure has been associated with decreased pregnancy rates. We examined the association of pregnancy loss in relation to urinary phthalate metabolites among women undergoing in-vitro fertilization and ovarian stimulation with and without intrauterine insemination.DesignA prospective cohort of 249 women conceiving 294 pregnancies from the Environment and Reproductive Health Study (EARTH) at the Massachusetts General Hospital Fertility Center.Materials and MethodsFour di(2-ethylhexyl) phthalate (DEHP) metabolites in urine were measured by the Centers for Disease Control and Prevention at two time points per woman during each fertility treatment cycle and the geometric mean urinary DEHP metabolite concentration was calculated. We estimated adjusted risk ratios (RRs) and 95% confidence intervals (CIs) for both biochemical and total pregnancy loss (<20 weeks gestation, including biochemical loss) by quartiles of DEHP metabolites, using a repeated measures log-binomial model accounting for multiple pregnancies. Models were adjusted for age, body mass index and smoking.ResultsOf the 294 pregnancies, 26% ended in pregnancy loss (11% in biochemical loss). The RR (95% CI) of biochemical loss increased across quartiles of ΣDEHP (molar sum of 4 metabolites): 2.6 (0.7, 9.0), 2.6 (0.8, 8.9), and 3.8 (1.2, 12.7) for quartiles 2, 3 and 4, compared to 1, respectively. Total pregnancy loss also increased by quartiles of ΣDEHP: 1.1 (0.6, 2.1), 1.3 (0.7, 2.3), and 1.5 (0.8, 2.6) for quartiles 2, 3 and 4 versus 1, respectively. Similar results were observed for the four individual DEHP metabolites.ConclusionsWomen undergoing medically assisted reproduction with higher concentrations of urinary DEHP metabolites had increased risk of pregnancy loss. ObjectiveSeveral phthalates are reproductive toxicants in animals and human occupational exposure has been associated with decreased pregnancy rates. We examined the association of pregnancy loss in relation to urinary phthalate metabolites among women undergoing in-vitro fertilization and ovarian stimulation with and without intrauterine insemination. Several phthalates are reproductive toxicants in animals and human occupational exposure has been associated with decreased pregnancy rates. We examined the association of pregnancy loss in relation to urinary phthalate metabolites among women undergoing in-vitro fertilization and ovarian stimulation with and without intrauterine insemination. DesignA prospective cohort of 249 women conceiving 294 pregnancies from the Environment and Reproductive Health Study (EARTH) at the Massachusetts General Hospital Fertility Center. A prospective cohort of 249 women conceiving 294 pregnancies from the Environment and Reproductive Health Study (EARTH) at the Massachusetts General Hospital Fertility Center. Materials and MethodsFour di(2-ethylhexyl) phthalate (DEHP) metabolites in urine were measured by the Centers for Disease Control and Prevention at two time points per woman during each fertility treatment cycle and the geometric mean urinary DEHP metabolite concentration was calculated. We estimated adjusted risk ratios (RRs) and 95% confidence intervals (CIs) for both biochemical and total pregnancy loss (<20 weeks gestation, including biochemical loss) by quartiles of DEHP metabolites, using a repeated measures log-binomial model accounting for multiple pregnancies. Models were adjusted for age, body mass index and smoking. Four di(2-ethylhexyl) phthalate (DEHP) metabolites in urine were measured by the Centers for Disease Control and Prevention at two time points per woman during each fertility treatment cycle and the geometric mean urinary DEHP metabolite concentration was calculated. We estimated adjusted risk ratios (RRs) and 95% confidence intervals (CIs) for both biochemical and total pregnancy loss (<20 weeks gestation, including biochemical loss) by quartiles of DEHP metabolites, using a repeated measures log-binomial model accounting for multiple pregnancies. Models were adjusted for age, body mass index and smoking. ResultsOf the 294 pregnancies, 26% ended in pregnancy loss (11% in biochemical loss). The RR (95% CI) of biochemical loss increased across quartiles of ΣDEHP (molar sum of 4 metabolites): 2.6 (0.7, 9.0), 2.6 (0.8, 8.9), and 3.8 (1.2, 12.7) for quartiles 2, 3 and 4, compared to 1, respectively. Total pregnancy loss also increased by quartiles of ΣDEHP: 1.1 (0.6, 2.1), 1.3 (0.7, 2.3), and 1.5 (0.8, 2.6) for quartiles 2, 3 and 4 versus 1, respectively. Similar results were observed for the four individual DEHP metabolites. Of the 294 pregnancies, 26% ended in pregnancy loss (11% in biochemical loss). The RR (95% CI) of biochemical loss increased across quartiles of ΣDEHP (molar sum of 4 metabolites): 2.6 (0.7, 9.0), 2.6 (0.8, 8.9), and 3.8 (1.2, 12.7) for quartiles 2, 3 and 4, compared to 1, respectively. Total pregnancy loss also increased by quartiles of ΣDEHP: 1.1 (0.6, 2.1), 1.3 (0.7, 2.3), and 1.5 (0.8, 2.6) for quartiles 2, 3 and 4 versus 1, respectively. Similar results were observed for the four individual DEHP metabolites. ConclusionsWomen undergoing medically assisted reproduction with higher concentrations of urinary DEHP metabolites had increased risk of pregnancy loss. Women undergoing medically assisted reproduction with higher concentrations of urinary DEHP metabolites had increased risk of pregnancy loss." @default.
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• W2130063893 date "2015-09-01" @default.
• W2130063893 modified "2023-09-28" @default.
• W2130063893 title "Urinary phthalate metabolite concentrations were associated with pregnancy loss among women conceiving with medically assisted reproduction" @default.
• W2130063893 doi "https://doi.org/10.1016/j.fertnstert.2015.07.115" @default.
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