FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2130068181> ?p ?o ?g. }

• W2130068181 abstract "In eukaryotic organisms, packaging of DNA into nucleosomes controls gene expression by regulating access of the promoter to transcription factors. The human malaria parasite Plasmodium falciparum encodes relatively few transcription factors, while extensive nucleosome remodeling occurs during its replicative cycle in red blood cells. These observations point towards an important role of the nucleosome landscape in regulating gene expression. However, the relation between nucleosome positioning and transcriptional activity has thus far not been explored in detail in the parasite.Here, we analyzed nucleosome positioning in the asexual and sexual stages of the parasite's erythrocytic cycle using chromatin immunoprecipitation of MNase-digested chromatin, followed by next-generation sequencing. We observed a relatively open chromatin structure at the trophozoite and gametocyte stages, consistent with high levels of transcriptional activity in these stages. Nucleosome occupancy of genes and promoter regions were subsequently compared to steady-state mRNA expression levels. Transcript abundance showed a strong inverse correlation with nucleosome occupancy levels in promoter regions. In addition, AT-repeat sequences were strongly unfavorable for nucleosome binding in P. falciparum, and were overrepresented in promoters of highly expressed genes.The connection between chromatin structure and gene expression in P. falciparum shares similarities with other eukaryotes. However, the remarkable nucleosome dynamics during the erythrocytic stages and the absence of a large variety of transcription factors may indicate that nucleosome binding and remodeling are critical regulators of transcript levels. Moreover, the strong dependency between chromatin structure and DNA sequence suggests that the P. falciparum genome may have been shaped by nucleosome binding preferences. Nucleosome remodeling mechanisms in this deadly parasite could thus provide potent novel anti-malarial targets." @default.
• W2130068181 created "2016-06-24" @default.
• W2130068181 creator A5012062096 @default.
• W2130068181 creator A5032942104 @default.
• W2130068181 creator A5040260693 @default.
• W2130068181 creator A5040408802 @default.
• W2130068181 creator A5042005042 @default.
• W2130068181 creator A5080073369 @default.
• W2130068181 creator A5065721893 @default.
• W2130068181 date "2014-05-08" @default.
• W2130068181 modified "2023-10-06" @default.
• W2130068181 title "DNA-encoded nucleosome occupancy is associated with transcription levels in the human malaria parasite Plasmodium falciparum" @default.
• W2130068181 cites W1961065093 @default.
• W2130068181 cites W1969503178 @default.
• W2130068181 cites W1974091218 @default.
• W2130068181 cites W1974527939 @default.
• W2130068181 cites W1982531329 @default.
• W2130068181 cites W1983970357 @default.
• W2130068181 cites W1984708728 @default.
• W2130068181 cites W1996270170 @default.
• W2130068181 cites W1996852546 @default.
• W2130068181 cites W1999659528 @default.
• W2130068181 cites W1999686286 @default.
• W2130068181 cites W2011326960 @default.
• W2130068181 cites W2011622850 @default.
• W2130068181 cites W2013571070 @default.
• W2130068181 cites W2019851585 @default.
• W2130068181 cites W2020251171 @default.
• W2130068181 cites W2027445913 @default.
• W2130068181 cites W2049303243 @default.
• W2130068181 cites W2052513749 @default.
• W2130068181 cites W2069545688 @default.
• W2130068181 cites W2079989301 @default.
• W2130068181 cites W2080748087 @default.
• W2130068181 cites W2084547321 @default.
• W2130068181 cites W2094998115 @default.
• W2130068181 cites W2096496718 @default.
• W2130068181 cites W2099397128 @default.
• W2130068181 cites W2099888659 @default.
• W2130068181 cites W2103441770 @default.
• W2130068181 cites W2104183138 @default.
• W2130068181 cites W2106448802 @default.
• W2130068181 cites W2108234281 @default.
• W2130068181 cites W2110312780 @default.
• W2130068181 cites W2114161957 @default.
• W2130068181 cites W2114803986 @default.
• W2130068181 cites W2118975679 @default.
• W2130068181 cites W2123799610 @default.
• W2130068181 cites W2125804133 @default.
• W2130068181 cites W2134314200 @default.
• W2130068181 cites W2135363003 @default.
• W2130068181 cites W2139739374 @default.
• W2130068181 cites W2142195360 @default.
• W2130068181 cites W2142991565 @default.
• W2130068181 cites W2147734340 @default.
• W2130068181 cites W2151383900 @default.
• W2130068181 cites W2152437699 @default.
• W2130068181 cites W2153369718 @default.
• W2130068181 cites W2154071457 @default.
• W2130068181 cites W2159407301 @default.
• W2130068181 cites W2164312318 @default.
• W2130068181 cites W2164365774 @default.
• W2130068181 cites W2170488656 @default.
• W2130068181 cites W2171605297 @default.
• W2130068181 cites W2259938310 @default.
• W2130068181 doi "https://doi.org/10.1186/1471-2164-15-347" @default.
• W2130068181 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4035074" @default.
• W2130068181 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24885191" @default.
• W2130068181 hasPublicationYear "2014" @default.
• W2130068181 type Work @default.
• W2130068181 sameAs 2130068181 @default.
• W2130068181 citedByCount "52" @default.
• W2130068181 countsByYear W21300681812014 @default.
• W2130068181 countsByYear W21300681812015 @default.
• W2130068181 countsByYear W21300681812016 @default.
• W2130068181 countsByYear W21300681812017 @default.
• W2130068181 countsByYear W21300681812018 @default.
• W2130068181 countsByYear W21300681812019 @default.
• W2130068181 countsByYear W21300681812020 @default.
• W2130068181 countsByYear W21300681812021 @default.
• W2130068181 countsByYear W21300681812022 @default.
• W2130068181 countsByYear W21300681812023 @default.
• W2130068181 crossrefType "journal-article" @default.
• W2130068181 hasAuthorship W2130068181A5012062096 @default.
• W2130068181 hasAuthorship W2130068181A5032942104 @default.
• W2130068181 hasAuthorship W2130068181A5040260693 @default.
• W2130068181 hasAuthorship W2130068181A5040408802 @default.
• W2130068181 hasAuthorship W2130068181A5042005042 @default.
• W2130068181 hasAuthorship W2130068181A5065721893 @default.
• W2130068181 hasAuthorship W2130068181A5080073369 @default.
• W2130068181 hasBestOaLocation W21300681811 @default.
• W2130068181 hasConcept C101762097 @default.
• W2130068181 hasConcept C104317684 @default.
• W2130068181 hasConcept C134320426 @default.
• W2130068181 hasConcept C150194340 @default.
• W2130068181 hasConcept C176619506 @default.
• W2130068181 hasConcept C203014093 @default.
• W2130068181 hasConcept C2778048844 @default.
• W2130068181 hasConcept C2778371730 @default.
• W2130068181 hasConcept C54355233 @default.

• next