FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2130074511> ?p ?o ?g. }

• W2130074511 endingPage "350" @default.
• W2130074511 startingPage "343" @default.
• W2130074511 abstract "ABSTRACT In Escherichia coli , the active transport of phenylalanine is considered to be performed by two different systems, AroP and PheP. However, a low level of accumulation of phenylalanine was observed in an aromatic amino acid transporter-deficient E. coli strain (Δ aroP Δ pheP Δ mtr Δ tna Δ tyrP ). The uptake of phenylalanine by this strain was significantly inhibited in the presence of branched-chain amino acids. Genetic analysis and transport studies revealed that the LIV-I/LS system, which is a branched-chain amino acid transporter consisting of two periplasmic binding proteins, the LIV-binding protein (LIV-I system) and LS-binding protein (LS system), and membrane components, LivHMGF, is involved in phenylalanine accumulation in E. coli cells. The K m values for phenylalanine in the LIV-I and LS systems were determined to be 19 and 30 μM, respectively. Competitive inhibition of phenylalanine uptake by isoleucine, leucine, and valine was observed for the LIV-I system and, surprisingly, also for the LS system, which has been assumed to be leucine specific on the basis of the results of binding studies with the purified LS-binding protein. We found that the LS system is capable of transporting isoleucine and valine with affinity comparable to that for leucine and that the LIV-I system is able to transport tyrosine with affinity lower than that seen with other substrates. The physiological importance of the LIV-I/LS system for phenylalanine accumulation was revealed in the growth of phenylalanine-auxotrophic E. coli strains under various conditions." @default.
• W2130074511 created "2016-06-24" @default.
• W2130074511 creator A5012057359 @default.
• W2130074511 creator A5068552779 @default.
• W2130074511 creator A5069292697 @default.
• W2130074511 creator A5071065949 @default.
• W2130074511 date "2004-01-15" @default.
• W2130074511 modified "2023-10-10" @default.
• W2130074511 title "Identification of the LIV-I/LS System as the Third Phenylalanine Transporter in <i>Escherichia coli</i> K-12" @default.
• W2130074511 cites W1485360994 @default.
• W2130074511 cites W1490719520 @default.
• W2130074511 cites W1492434437 @default.
• W2130074511 cites W1495538657 @default.
• W2130074511 cites W1514779020 @default.
• W2130074511 cites W1527655323 @default.
• W2130074511 cites W1529350605 @default.
• W2130074511 cites W1538992569 @default.
• W2130074511 cites W1556021230 @default.
• W2130074511 cites W1568412588 @default.
• W2130074511 cites W1569067757 @default.
• W2130074511 cites W1573072982 @default.
• W2130074511 cites W1582440271 @default.
• W2130074511 cites W1590962145 @default.
• W2130074511 cites W1595711988 @default.
• W2130074511 cites W1635112036 @default.
• W2130074511 cites W1642411047 @default.
• W2130074511 cites W1700612191 @default.
• W2130074511 cites W175432153 @default.
• W2130074511 cites W1761200347 @default.
• W2130074511 cites W1789043041 @default.
• W2130074511 cites W1832355425 @default.
• W2130074511 cites W1909514749 @default.
• W2130074511 cites W1950257967 @default.
• W2130074511 cites W1953872558 @default.
• W2130074511 cites W1963304224 @default.
• W2130074511 cites W1964051185 @default.
• W2130074511 cites W1987966003 @default.
• W2130074511 cites W1999228135 @default.
• W2130074511 cites W200338845 @default.
• W2130074511 cites W2014361215 @default.
• W2130074511 cites W2028738629 @default.
• W2130074511 cites W2029392002 @default.
• W2130074511 cites W2042058258 @default.
• W2130074511 cites W2073043298 @default.
• W2130074511 cites W2093588463 @default.
• W2130074511 cites W2100476057 @default.
• W2130074511 cites W2107205153 @default.
• W2130074511 cites W2110535195 @default.
• W2130074511 cites W2110704748 @default.
• W2130074511 cites W2116137883 @default.
• W2130074511 cites W2124851584 @default.
• W2130074511 cites W2128161317 @default.
• W2130074511 cites W2134153749 @default.
• W2130074511 cites W2141653906 @default.
• W2130074511 cites W2145340452 @default.
• W2130074511 cites W2156075398 @default.
• W2130074511 cites W2157476995 @default.
• W2130074511 cites W2158892486 @default.
• W2130074511 cites W2170761691 @default.
• W2130074511 cites W67779518 @default.
• W2130074511 doi "https://doi.org/10.1128/jb.186.2.343-350.2004" @default.
• W2130074511 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/305776" @default.
• W2130074511 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14702302" @default.
• W2130074511 hasPublicationYear "2004" @default.
• W2130074511 type Work @default.
• W2130074511 sameAs 2130074511 @default.
• W2130074511 citedByCount "36" @default.
• W2130074511 countsByYear W21300745112012 @default.
• W2130074511 countsByYear W21300745112013 @default.
• W2130074511 countsByYear W21300745112015 @default.
• W2130074511 countsByYear W21300745112016 @default.
• W2130074511 countsByYear W21300745112018 @default.
• W2130074511 countsByYear W21300745112019 @default.
• W2130074511 countsByYear W21300745112020 @default.
• W2130074511 countsByYear W21300745112021 @default.
• W2130074511 countsByYear W21300745112022 @default.
• W2130074511 countsByYear W21300745112023 @default.
• W2130074511 crossrefType "journal-article" @default.
• W2130074511 hasAuthorship W2130074511A5012057359 @default.
• W2130074511 hasAuthorship W2130074511A5068552779 @default.
• W2130074511 hasAuthorship W2130074511A5069292697 @default.
• W2130074511 hasAuthorship W2130074511A5071065949 @default.
• W2130074511 hasBestOaLocation W21300745111 @default.
• W2130074511 hasConcept C104317684 @default.
• W2130074511 hasConcept C190114821 @default.
• W2130074511 hasConcept C201663137 @default.
• W2130074511 hasConcept C20950039 @default.
• W2130074511 hasConcept C2776165026 @default.
• W2130074511 hasConcept C2776580952 @default.
• W2130074511 hasConcept C2777305461 @default.
• W2130074511 hasConcept C2777431362 @default.
• W2130074511 hasConcept C2777573094 @default.
• W2130074511 hasConcept C2777992278 @default.
• W2130074511 hasConcept C515207424 @default.
• W2130074511 hasConcept C547475151 @default.
• W2130074511 hasConcept C55493867 @default.
• W2130074511 hasConcept C86803240 @default.
• W2130074511 hasConceptScore W2130074511C104317684 @default.

• next