FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2130081367> ?p ?o ?g. }

• W2130081367 endingPage "234" @default.
• W2130081367 startingPage "226" @default.
• W2130081367 abstract "Several animal models are discussed in order to outline features of difficult-to-treat or drug-resistant epilepsy. These models can be categorised as those which show a poor response to different antiepileptic drugs and those in which subgroups of drug-resistant animals are selected, based on interindividual differences. Non-responders to antiepileptic drugs have been described in the amygdala kindling model, as well as the chronic phase of post-status epilepticus models. Epileptic dogs which do not respond to standard antiepileptic drugs may serve as a translational model to provide a more clinical environment for drug testing. Drug resistance or a poor response to several antiepileptic drugs has been reported for the 6-Hz model, lamotrigine-pretreated kindled rats, pentylentetrazole-induced seizures in rats pre-exposed to pilocarpine, as well as following intrauterine exposure of rats to methylazoxymethanol. Using models to select non-responders is highly time-consuming and elaborate, limiting their use in routine drug-screening procedures. Current efforts to identify biomarkers of drug resistance may simplify the selection process, e.g. replacing several weeks of seizure monitoring by a single imaging scan. Moreover, further elucidation of mechanisms of resistance may help to design a series of ex vivo or in vitro screening procedures in order to evaluate whether a test compound is affected." @default.
• W2130081367 created "2016-06-24" @default.
• W2130081367 creator A5040549226 @default.
• W2130081367 date "2012-09-01" @default.
• W2130081367 modified "2023-09-27" @default.
• W2130081367 title "Animal models of drug-resistant epilepsy" @default.
• W2130081367 cites W1482454189 @default.
• W2130081367 cites W1487497909 @default.
• W2130081367 cites W1590926633 @default.
• W2130081367 cites W1911121734 @default.
• W2130081367 cites W1965016243 @default.
• W2130081367 cites W1965703970 @default.
• W2130081367 cites W1966251521 @default.
• W2130081367 cites W1966798504 @default.
• W2130081367 cites W1968066079 @default.
• W2130081367 cites W1969624931 @default.
• W2130081367 cites W1969733588 @default.
• W2130081367 cites W1970580718 @default.
• W2130081367 cites W1972894928 @default.
• W2130081367 cites W1978672997 @default.
• W2130081367 cites W1983016447 @default.
• W2130081367 cites W1983419469 @default.
• W2130081367 cites W1992813876 @default.
• W2130081367 cites W1998383877 @default.
• W2130081367 cites W2002366879 @default.
• W2130081367 cites W2003439788 @default.
• W2130081367 cites W2003466563 @default.
• W2130081367 cites W2014281284 @default.
• W2130081367 cites W2016871340 @default.
• W2130081367 cites W2017398416 @default.
• W2130081367 cites W2022005638 @default.
• W2130081367 cites W2029830651 @default.
• W2130081367 cites W2033202122 @default.
• W2130081367 cites W2039203321 @default.
• W2130081367 cites W2039427231 @default.
• W2130081367 cites W2041825323 @default.
• W2130081367 cites W2042126821 @default.
• W2130081367 cites W2048447338 @default.
• W2130081367 cites W2055879442 @default.
• W2130081367 cites W2082770075 @default.
• W2130081367 cites W2100283245 @default.
• W2130081367 cites W2111025023 @default.
• W2130081367 cites W2130375794 @default.
• W2130081367 cites W2134468198 @default.
• W2130081367 cites W2138606636 @default.
• W2130081367 cites W2141957690 @default.
• W2130081367 cites W2148059993 @default.
• W2130081367 cites W2164573587 @default.
• W2130081367 cites W2169006271 @default.
• W2130081367 cites W2277643767 @default.
• W2130081367 cites W2317758052 @default.
• W2130081367 doi "https://doi.org/10.1684/epd.2012.0532" @default.
• W2130081367 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22947487" @default.
• W2130081367 hasPublicationYear "2012" @default.
• W2130081367 type Work @default.
• W2130081367 sameAs 2130081367 @default.
• W2130081367 citedByCount "40" @default.
• W2130081367 countsByYear W21300813672013 @default.
• W2130081367 countsByYear W21300813672014 @default.
• W2130081367 countsByYear W21300813672015 @default.
• W2130081367 countsByYear W21300813672016 @default.
• W2130081367 countsByYear W21300813672017 @default.
• W2130081367 countsByYear W21300813672018 @default.
• W2130081367 countsByYear W21300813672019 @default.
• W2130081367 countsByYear W21300813672020 @default.
• W2130081367 countsByYear W21300813672021 @default.
• W2130081367 countsByYear W21300813672022 @default.
• W2130081367 countsByYear W21300813672023 @default.
• W2130081367 crossrefType "journal-article" @default.
• W2130081367 hasAuthorship W2130081367A5040549226 @default.
• W2130081367 hasConcept C114851261 @default.
• W2130081367 hasConcept C118552586 @default.
• W2130081367 hasConcept C2777204577 @default.
• W2130081367 hasConcept C2777341932 @default.
• W2130081367 hasConcept C2778186239 @default.
• W2130081367 hasConcept C2778802184 @default.
• W2130081367 hasConcept C2780035454 @default.
• W2130081367 hasConcept C2910833928 @default.
• W2130081367 hasConcept C2994127763 @default.
• W2130081367 hasConcept C71924100 @default.
• W2130081367 hasConcept C86803240 @default.
• W2130081367 hasConcept C89423630 @default.
• W2130081367 hasConcept C98274493 @default.
• W2130081367 hasConceptScore W2130081367C114851261 @default.
• W2130081367 hasConceptScore W2130081367C118552586 @default.
• W2130081367 hasConceptScore W2130081367C2777204577 @default.
• W2130081367 hasConceptScore W2130081367C2777341932 @default.
• W2130081367 hasConceptScore W2130081367C2778186239 @default.
• W2130081367 hasConceptScore W2130081367C2778802184 @default.
• W2130081367 hasConceptScore W2130081367C2780035454 @default.
• W2130081367 hasConceptScore W2130081367C2910833928 @default.
• W2130081367 hasConceptScore W2130081367C2994127763 @default.
• W2130081367 hasConceptScore W2130081367C71924100 @default.
• W2130081367 hasConceptScore W2130081367C86803240 @default.
• W2130081367 hasConceptScore W2130081367C89423630 @default.
• W2130081367 hasConceptScore W2130081367C98274493 @default.
• W2130081367 hasIssue "3" @default.
• W2130081367 hasLocation W21300813671 @default.

• next