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• W2130103448 abstract "<h3>Abstract</h3> DNA methylation is an epigenetic mark that has vital importance in both development and disease. Single cell bisulfite sequencing technologies enable profiling of the methylome at high resolution, providing the basis for dissecting the heterogeneity and dynamics of DNA methylation in complex tissues and over time. Despite the rapid increase in the number of experimental protocols for methylome sequencing, analytical tools designed specifically for single-cell data are lacking. We developed a computational tool, SINBAD, for efficient and standardized pre-processing, quality assessment and analysis of single cell methylation data. Starting from multiplexed sequencing reads, major analysis modules of SINBAD include preprocessing, read mapping, methylation quantification, multivariate analysis, and gene signature profiling. SINBAD provides a flexible platform to implement interoperable and robust processing of single-cell methylome data." @default.
• W2130103448 created "2016-06-24" @default.
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• W2130103448 date "1998-01-01" @default.
• W2130103448 modified "2023-10-10" @default.
• W2130103448 title "Spinocerebellar ataxia type 6: genotype and phenotype in German kindreds" @default.
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• W2130103448 doi "https://doi.org/10.1136/jnnp.64.1.67" @default.
• W2130103448 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2169927" @default.
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