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- W2130107304 endingPage "658" @default.
- W2130107304 startingPage "631" @default.
- W2130107304 abstract "The fixation of inorganic carbon into organic material (autotrophy) is a prerequisite for life and sets the starting point of biological evolution. In the extant biosphere the reductive pentose phosphate (Calvin-Benson) cycle is the predominant mechanism by which many prokaryotes and all plants fix CO 2 into biomass. However, the fact that five alternative autotrophic pathways exist in prokaryotes is often neglected. This bias may lead to serious misjudgments in models of the global carbon cycle, in hypotheses on the evolution of metabolism, and in interpretations of geological records. Here, I review these alternative pathways that differ fundamentally from the Calvin-Benson cycle. Revealingly, these five alternative pathways pivot on acetyl-coenzyme A, the turntable of metabolism, demanding a gluconeogenic pathway starting from acetyl-coenzyme A and CO 2 . It appears that the formation of an activated acetic acid from inorganic carbon represents the initial step toward metabolism. Consequently, biosyntheses likely started from activated acetic acid and gluconeogenesis preceded glycolysis." @default.
- W2130107304 created "2016-06-24" @default.
- W2130107304 creator A5067757516 @default.
- W2130107304 date "2011-10-13" @default.
- W2130107304 modified "2023-10-11" @default.
- W2130107304 title "Alternative Pathways of Carbon Dioxide Fixation: Insights into the Early Evolution of Life?" @default.
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